Natural Products
| Catalog No. | Information |
| CFN99481 | 2,24-Dihydroxyursolic acid 2,24-Dihydroxyursolic acid shows DPPH free radical scavenging and superoxide anion scavenging activity. |
| CFN99482 | Jaceidin triacetate Reference standards. |
| CFN99483 | 6-O-Syringoylajugol 6-O-Syringoylajugol posseses antioxidant activity. |
| CFN99521 | Epigoitrin Epigoitrin and fructopyrano-(1→4)-glucopyranose(FG) from the traditional Chinese medicine Isatidis radix, exhibit in vitro cooperation, they have in vitro anti-virus activity. |
| CFN99522 | Plantamajoside Plantamajoside has antibacterial, antioxidant, anti-tumor, anti-inflammatory and anti-skin photoaging effects, it has protective activities against Cadmium-induced renal injury. Plantamajoside ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation, it can inhibit UVB and advanced glycation end products‐induced MMP-1 Expression by suppressing the MAPK and NF‐ĸB pathways in HaCaT cells, and attenuate the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation. |
| CFN99523 | Monotropein Monotropein has anti-antiosteoporosis and anti-inflammatory activities, it exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes and can increase osteoblastic bone formation and prevent bone loss in ovariectomized mice. |
| CFN99524 | Crotonoside Crotonoside is one compound of an antitumor and immunity-regulating pharmaceutical composition of traditional Chinese medicine. |
| CFN99525 | Complanatoside A Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia. |
| CFN99526 | Amentoflavone Amentoflavone is a novel natural inhibitor of human Cathepsin B(CatB), which has antifungal , antioxidant, antiviral, antidiabetic, and neuroprotective activities, it stimulates apoptosis in HSFBs and inhibits angiogenesis of endothelial cells, it is a promising molecule that can be used in hypertrophic scar treatment. Amentoflavone regulated β-catenin and caspase-3 expressions, and inhibited NF-κB signal transduction pathways. |
| CFN99527 | Pseudolaric Acid B Pseudolaric Acid B has dual antiangiogenic, anti-fungal, anti-fertility, anti-inflammatory, immunomodulatory and pro-apoptosis effects. Pseudolaric Acid B reversed the multidrug resistance of gastric neoplasm to chemotherapy drugs by downregulating the Cox-2/PKC-α/P-gp/mdr1 signaling pathway, it suppressed T lymphocyte activation through inhibition of NF-κB and p38 signaling pathways. |
| CFN99528 | Norisoboldine Norisoboldine produces anti-inflammatory and anti-rheumatoid arthritis effects, it produces the analgesic effect in inflammatory pain by a mechanism related to the adenosine system. Norisoboldine alleviated joint destruction in AIA rats by reducing RANKL, IL-6, PGE2, and MMP-13 expression via the p38/ERK/AKT/AP-1 pathway, it decreased forskolin-evoked cyclic adenosine monophosphate levels in mouse spinal cord neuronal cultures through the adenosine A1 receptor. |
| CFN99529 | Leonurine hydrochloride Leonurine hydrochloride has anti-oxidative, anti-inflammatory, and antitumor activities, it exerts antidiabetic, cardiovascular, and bovine mastitis protection, it has an inhibitory effect on bleeding caused by incomplete abortion. Leonurine hydrochloride increases the expression levels of caspase-3, caspase-9 and Bax/Bcl-2, and it inhibits osteoclastogenesis and prevent osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways. |
| CFN99530 | Ruscogenin Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities.Ruscogenin significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, it inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways. |
| CFN99531 | 6-Shogaol 6-Shogaol has anti-cancer, neuroprotective, anti-inflammatory effects, it can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing of TLR4/NF-κB-mediated inflammatory pathways linked to tumorigenesis. 6-Shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER) stress signaling, affects the ER stress signaling by regulating unfolded protein response (UPR) sensor PERK and its downstream target eIF2α. |
| CFN99532 | Anemarsaponin B Anemarsaponin B can inhibit PAF-induced rabbit platelet aggregation in vitro. Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. |
| CFN99533 | Anemarsaponin E Anemarsaponin E is a nartural product from salt Anemarrhenae Rhizoma. |
| CFN99534 | Arctigenin Arctigenin has anti-tumor, anti-inflammation, antioxidative , neuroprotection, and endurance enhancement effects; it efficiently enhances rat swimming endurance by elevation of the antioxidant capacity of the skeletal muscles, which has thereby highlighted the potential of this natural product as an antioxidant in the treatment of fatigue and related diseases. Arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice, this highlights the potential value of arctigenin as a possible treatment of type 2 diabetes. |
| CFN99535 | Atractylodin Atractylodin has a good potential as a source for natural repellents, it could be developed as natural insecticide. Atractylodin has high lipase inhibitory activity with the IC50 of 39.12 μM. |
| CFN99536 | Benzoylpaeoniflorin Benzoylpaeoniflorin is active against cyclooxygenase(COX)-1 and COX-2 enzymes, it can restrain apoptosis of rats with coronary heart diseases by increasing the levels of Bc1-2 and decreasing the levels of Bax. |
| CFN99537 | beta-Eudesmol Beta-eudesmol has potential anti-angiogenic and anti-tumour activities, it inhibits angiogenesis by suppressing CREB activation in growth factor signalling pathway, is an inhibitor of tumour growth. Beta-eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase, it may be a promising lead compound for potentiating neuronal function, and the drug may be useful in helping to clarify the mechanisms underlying neuronal differentiation. |
| CFN99484 | Dehydroadynerigenin glucosyldigitaloside Reference standards. |
| CFN99485 | 8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen Reference standards. |
| CFN99538 | Cycloastragenol Cycloastragenol has been shown to extend T cell proliferation by increasing telomarase activity showing that it may also help delay the onset of cellular aging; it is an extraordinary wound healing agent; it inhibits the apoptosis of PC12 induced by 6-OHDA, may be as potential neuroprotective agents in the treatment of Parkinson's disease. Cycloastragenol and astragaloside IV can suppress ROS-associated ER stress and then inhibit TXNIP/NLRP3 inflammasome activation with regulation of AMPK activity, and thereby ameliorate endothelial dysfunction by inhibiting inflammation and reducing cell apoptosis. Cycloastragenol and astragaloside IV have been shown to improve the proliferative response of CD8+ T lymphocytes from HIV-infected patients by upregulating telomerase activity, they also may exert their cellular effects through the activation of the Src/MEK/ERK pathway. |
| CFN99539 | Danshensu Danshensu has anxiolytic-like, cardioprotective, neuroprotective, and antioxidant activities. It can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways and can reduce 6-OHDA-induced dopaminergic neuronal loss in zebrafish. Chronic treatment with danshensu can prevent/attenuate the formation of atherosclerosis. |
| CFN99540 | Dihydrocurcumin Dihydrocurcumin is an intermediate product converted from curcumin. |
| CFN99541 | D-(-)-Salicin D(-)-Salicin is a traditional medicine which has been known to exhibit anti-inflammation and other therapeutic activities, it can inhibit the LPS-induced inflammation in RAW264.7 cells and mouse models. |
| CFN99542 | Silymarin Silymarin possesses hepatoprotective, antioxidant, anti-inflammatory and immunomodulatory properties. It is an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. It inhibits PGE2 -induced cell migration through inhibition of EP2 signaling pathways (G protein dependent PKA-CREB and G protein-independent Src-STAT3).  |
| CFN99543 | Narirutin Citrus narirutin fraction (CNF), contained 75% of narirutin, co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines. Narirutin has anti-inflammatory effect in a murine model of allergic eosinophilic airway inflammation, the mechanism is likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE. |
| CFN99544 | Paeoniflorin Paeoniflorin, a novel heat shock protein-inducing compound, is mediated by the activation of heat shock transcription factor 1 (HSF1), which has antiallergic, anti-obesity, anti-inflammatory and immunoregulatory effects. Paeoniflorin can activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35, it protects thymocytes against irradiation-induced cell damage by scavenging ROS and attenuating the activation of the mitogen-activated protein kinases. |
| CFN99545 | L-Rhamnose L-Rhamnose may exhibit excellent sodium-glucose transporter (SGLT1 and SGLT2) inhibition activity. L-fucose and especially L-rhamnose have anticancer potential, they exert a significant suppressive effect on tumour growth. |
| CFN99546 | Betaine Betaine protects cells from environmental stress and serves as a methyl donor in several biochemical pathways, it reduces cardiovascular disease risk and protects liver cells from alcoholic liver damage and nonalcoholic steatohepatitis. Betaine has anti-inflammation and tumor preventing capacity, it can inhibit inflammatory cytokines such TNF-α, IL-6, iNOS and COX-2 and decrease the incidence of tumor formation with downregulation of inflammation. |
| CFN99547 | Betaine hydrochloride Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns, which has anti-hypoxic, hepatoprotective, sedative, antipyretic and analgesic effects. Betaine hydrochloride can increase the secreting of thyroxine (T3) and insulin and regulate the metabolism of organism by the hormones, thus it prompts fish growth and also improves intestine figuration. |
| CFN99548 | Stevioside Stevioside is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside enjoys a dual positive effect by acting as an antihyperglycemic and a blood pressure-lowering substance, it may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome.Stevioside exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax. |
| CFN99549 | Gastrodin Gastrodin has antioxidant, cytoprotective, anticonvulsant, and anti-inflammation activities, it may be useful in the prevention and treatment of osteoporosis. Gastrodin also has protective effect to the prevention of neurotoxicity induced by ischemic stroke, the mechanism is by improving anti-oxidant and anti-inflammation activities, inhibiting apoptosis pathway, and increasing Akt phosphorylation and Nrf2 expression. Gastrodin activates PI3-K/Akt signaling and that inhibition of this pathway reverses the inhibitory effects of gastrodin on NF-κB and MAPKs activation in H9c2 cardiomyocytes. |
| CFN99550 | Arbutin Arbutin is a tyrosinase inhibitor with an IC50 of 1.09 mM, which has gastroprotective, whitening, anti- age, anti-oxidant , anti-inflammatory, a depigmenting effects and UVB/ UVC filter. Arbutin has mutagenicity in mammalian cells after activation by human intestinal bacteria. |
| CFN99551 | Synephrine p-Synephrine is widely used in weight loss and weight management as well as in sports performance products, which has antidepressant-like effects in the murine models of forced swimming and tail suspension, it also exerts potent anti-inflammatory effects by inhibition of the NF-κB signaling pathway. Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway. |
| CFN99552 | Coumarin Coumarin is an anticoagulant and photoprotective drug; it also has antiulcerogenic activity, which may influence the secretion control mediated by the parasympathetic system. Coumarin is a potent inducer of aflatoxin B1-aldehyde reductase, has chemoprevention of aflatoxin B1 hepatocarcinogenesis. |
| CFN99553 | Tetrahydropalmatine Tetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. Tetrahydropalmatine shows a promyogenic effect by upregulation of p38MAPK, Akt resulting in enhanced MyoD activation, it can effectively protect endothelial cells against γ-irradiation injury. Tetrahydropalmatine has a potential as a therapeutic candidate to prevent fibrosis and improve muscle regeneration and repair and applied to the prevention of endothelial cell dysfunctions associated with ionizing irradiation-induced lung injury. |
| CFN99554 | Icariin Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Icariin has been reported to have anti-hypoxic, phytoestrogenic, anti-osteoporotic, anti-inflammatory, neuroprotective, and anti-depressant-like activities. Icariin is effective in the attenuation of AHR and chronic airway inflammatory changes in OVA-induced murine asthma model, and this effect is associated with regulation of Th17/Treg responses. Icariin inhibited NF-κB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1β axis. |
| CFN99486 | 3-O-(E)-p-Coumaroylbetulin 3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM. |
| CFN99487 | 22-Hydroxy-3-oxoolean-12-en-29-oic acid Reference standards. |
| CFN99488 | (+)-Lyoniresinol Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression. |
| CFN99489 | 2-4-Hydroxy-3-methoxyphenyl-7-methoxy-5-benzofuranpropanol Reference standards. |
| CFN99490 | Brachynoside heptaacetate Reference standards. |
| CFN99491 | Hispidulin Hispidulin has anti-oxidative, anti-inflammatory, anti-cancer, antiepileptic, neuroprotective, anti-osteoporotic and bone resorption attenuating effects, it targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1. |
| CFN99492 | Garjasmin Garjasmine exhibits weak cytotoxic activity against KB and MCF-7 cell lines. |
| CFN99493 | Junipediol B Junipediol B shows antioxidation activity. |
| CFN99494 | 4',9,9'-Trihydroxy-3'-methoxy-3,7'-epoxy-4,8'-oxyneolignan Reference standards. |
| CFN99495 | 21-Episerratenediol 21-Episerratenediol may be as a potent cancer chemopreventive agent. |
| CFN99496 | 24-Methylenecycloartan-3-ol 24-Methylenecycloartan-3-ol and methyl caffeate show weak activity against Staphylococcus aureus and Escherichia coli. |
