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Ceanothic acid
Ceanothic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ceanothic acid
Price:
CAS No.: 21302-79-4
Catalog No.: CFN98063
Molecular Formula: C30H46O5
Molecular Weight: 486.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The seeds of Ziziphus jujuba
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.
In vitro:
J Nat Prod. 1998 Nov;61(11):1343-7.
Preparation and cytotoxic effect of ceanothic acid derivatives.[Pubmed: 9834149 ]

METHODS AND RESULTS:
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from Ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-Ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.
Ceanothic acid Description
Source: The seeds of Ziziphus jujuba
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0547 mL 10.2733 mL 20.5465 mL 41.0931 mL 51.3663 mL
5 mM 0.4109 mL 2.0547 mL 4.1093 mL 8.2186 mL 10.2733 mL
10 mM 0.2055 mL 1.0273 mL 2.0547 mL 4.1093 mL 5.1366 mL
50 mM 0.0411 mL 0.2055 mL 0.4109 mL 0.8219 mL 1.0273 mL
100 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.4109 mL 0.5137 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Journal of the Chinese Chemical Society.1993 Apr;40(2):213–216.
Microbial Transformation of Ceanothic Acid and Derivatives by Mycobacterium sp.[Reference: WebLink]

METHODS AND RESULTS:
Ceanothic acid (1) is the major triterpene isolated from Parliurus ramosissitnus (Rhamnaceae) which possesses three methyl groups corresponding to the 4,4,14α-trimethyl groups in lanosterol (5). Microbial transformation of Ceanothic acid and its 3-dehydro-2,28-dimethyl ester derivative (3) with Mycobacterium sp. (NRRL B-3805) resulted in the methylation of the carboxylic functions and C-1 epimerization, respectively.
CONCLUSIONS:
Although this work indicates that Ceanothic acid is not a suitable substrate for 4,4,14α-tridemethylation, esterification of the carboxylic function and the C-1 epimerization reaction in Ceanothic acid and its derivative is the first observation with this microorganism.
CFN980721-Decarboxy-3-oxo-ceanothic acid214150-74-0440.7 C29H44O3
CFN98063Ceanothic acid21302-79-4486.7 C30H46O5
CFN99309Ceanothic acid acetate119533-63-0528.7 C32H48O6
CFN969403,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid36138-41-7470.69C30H46O4
CFN90571Chiisanoside89354-01-8955.10C48H74O19
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