Natural Products
| Catalog No. | Information |
| CFN93039 | Hypaconine Hypaconine exhibits strong cardiac activity. |
| CFN93040 | Sargentol Reference standards. |
| CFN93041 | Glabrone Glabrone shows antiviral activity against influenza virus. It also exhibits significant PPAR-gamma ligand-binding activity. |
| CFN93042 | Glabrol Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15 uM. Glabrol has hypnotic effects, it induces sleep via a positive allosteric modulation of GABA(A)-BZD receptors. Glabrol possesses significant antimicrobial activity in vitro. Glabrol may have potential therapy for the treatment in obesity and type 2 diabetes patients, it shows a noncompetitive type of inhibition against diacylglycerol acyltransferase (DGAT) with an IC50 value of 8.0 microM. |
| CFN93043 | Sarracenin Reference standards. |
| CFN93044 | 1,1,1-Kestopentaose Reference standards. |
| CFN93045 | Lindleyin Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens. |
| CFN93046 | Erigeroside Erigeroside has the protective effects on cerebral ischemia-reperfusion injury in rat, its ability of anti-oxidation and scavenging oxidation free radical may be one of its protective mechanisms. |
| CFN93047 | Pomiferin Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities, it is effective in enhancing the activity of NSAID activated gene (NAG-1) at 2.5 pg/mL (1.5-1.8 fold increase) and inhibiting iNOS and NF-κB activity with IC50 values in the range of 6-13 ug/mL. Pomiferin has protection on kidney ischaemia-reperfusion injury in rats. |
| CFN93048 | Aloperine Aloperine has antitumor effects , it can suppress the tumor growth and promote cell apoptosis and cell cycle arrest in PCa cells. It attenuates hydrogen peroxide-induced injury via anti-apoptotic activity and suppression of the nuclear factor-κB signaling pathway. Aloperine exhibits neuroprotective effects against oxidative stress in vitro, it can ameliorate oxidative damage against early brain injury following subarachnoid hemorrhage , most likely via the Nrf2-ARE survival pathway. Aloperine exerts significant inhibitive effects on acute inflammation and Type III and IV hypersensitivity caused by a variety of inflammatory agents. It protects mice against bleomycin-induced pulmonary fibrosis by attenuating fibroblast proliferation and differentiation. |
| CFN93049 | Clitorin Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential. |
| CFN93052 | Deltonin Deltonin may be a potential chemotherapeutic agent against neck squamous cell carcinoma (HNSCC), it can induce both apoptosis and autophagy in head and neck squamous carcinoma FaDu cell; it also induces apoptosis in MDA-MB-231 human breast cancer cells via reactive oxygen species-mediated mitochondrial dysfunction and ERK/AKT signaling pathways. Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells.Deltonin also exhibits induction effect on platelet aggregation. |
| CFN93053 | Acitretin Acitretin has immunomodulatory effect, and low dose acitretin therapy is safe, well tolerated and partially effective in chemoprophylaxis of skin cancer in renal transplant recipients, it for chemoprevention of non-melanoma skin cancers in renal transplant recipients. Acitretin dramatically improves the results of UV-B treatment in patients with severe psoriasis and it markedly decreases the effective cumulative UV-B dose. Acitretin in the treatment of severe lichen sclerosus et atrophicus of the vulva. Acitretin therapy is effective for psoriasis associated with human immunodeficiency virus infection. |
| CFN93054 | Protogracillin Protogracillin may have inhibitions on platelet aggregation (PAG) and thrombosis. |
| CFN93055 | Protohypericin Protohypericin exhibits photocytotoxicity. |
| CFN93056 | 13-Methylberberine 13-Methylberberine shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug. It also can be useful as an immunotherapeutic compound for induction of IL-12, which is potentially applicable for tumors, infectious disease, and airway inflammation. 13-Methylberberine may reduce circulating HMGB1 levels and increase survival in a mouse model of sepsis by activating AMP-activated protein kinase (AMPK). |
| CFN93057 | Isorhamnetin 3-robinobioside Isorhamnetin 3-O-robinobioside has a great antioxidant and antigenotoxic potential on human chronic myelogenous leukemia cell line K562. |
| CFN93058 | 4-Methylesculetin 4-Methylesculetin displays a potent metal chelating agent. 4-Methylesculetin has cytotoxicity, it inhibits pancreatic cancer growth and metastasis by inhibition of hyaluronan synthesis. 4-Methylesculetin has great anti-oxidant and anti-inflammatory activities, it has a promising potentiality to treat inflammatory diseases, especially those related to reactive oxygen species, as inflammatory bowel disease, it could be an effective agent to treat arthritis and associated secondary complications like oxidative stress. |
| CFN93059 | Galgravin Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protect against neuronal death from 1-methyl-4-phenylpyridinium ion (MPP+)-induced toxicity in cultured rat hippocampal neurons. Galgravin has cytotoxic activity against human leukemia (HL-60) tumor cells with the IC50 value of 16.5 ± 0.8 ug/mL. Galgravin also can inhibit bone resorption and may offer a novel compounds for the development of drugs to treat bone-destructive diseases such as osteoporosis. |
| CFN93060 | Karanjin Karanjin is a potent Volume-regulated anion channels(VRACs) current inhibitor, the VRAC inhibition might be responsible for its anti-angiogenic effects. Karanjin possesses antioxidant, anti-inflammatory, gastroprotective properties, it can significantly reverse the amnesia induced by diazepam and improve learning and memory of mice in dose and time dependent manner. Karanjin may be effective clinically for cancer pharmacotherapy, it can induce cancer cell death through cell cycle arrest and enhance apoptosis. Karanjin has larvicidal activity toward C. pipiens pallens larvae and A. aegypti larvae. Karanjin also possesses significant antihyperglycemic activity in Streptozotocin-induced diabetic rats and type 2 diabetic db/db mice and protein tyrosine phosphatase-1B may be the possible target for their activity. |
| CFN95072 | Licoarylcoumarin Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase. |
| CFN95073 | Dihydrolicoisoflavone Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals. |
| CFN93062 | Bryodulcosigenin Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction. |
| CFN93064 | Guaiazulene Guaiazulene has antioxidant activity, it shows significant protection against paracetamol-induced GSH depletion and hepatic damage. Guaiazulene shows cytotoxic activity on gingival fibroblasts, it has anti-proliferative activity suppressing the proliferation of neuron and N2a-NB cells at high doses. Guaiazulene has in vitro antimicrobial activity against Mycoplasma hominis clinical isolates. |
| CFN93065 | Nordalbergin Reference standards. |
| CFN93067 | Veratrosine Reference standards. |
| CFN93068 | Steviol Steviol, a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation. Steviol can induce a significant increase in CYP3A29 expression. |
| CFN93069 | 1-Kestose 1-Kestose shows significant anti-hydroxyl radical potential. 1-Kestose can promote intestinal Lactobacillus number, and influence the microorganisms as well as the intestinal and systemic immune responses. |
| CFN93070 | Marinobufagenin Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. Marinobufagenin is also an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Marinobufagenin also can induce proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. |
| CFN93071 | Cafestol Cafestol has anticarcinogenic, peripheral antinociceptive and anti-inflammatory activities, it inhibits Cyclic-Strain-induced interleukin-8, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 production in vascular endothelial cells. Cafestol is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis. Cafestol has protective effects against the CCl(4)-induced hepatotoxicity, which possibly involve mechanisms related to its ability to block the CYP2E1-mediated CCl(4) bioactivation and free radical scavenging effects. Cafestol has antidiabetic activity, it increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. Cafestol also has a weak inhibitory effect on osteoclastogenesis and promotes osteoblast differentiation. |
| CFN93072 | Buxtamine Reference standards. |
| CFN93073 | Desacetylcinobufotalin Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines. |
| CFN93074 | Karacoline Reference standards. |
| CFN93075 | Neodiosmin Neodiosmin has poor aqueous solubility but exerts a good debittering effect and is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations. |
| CFN93076 | Bacopaside I Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid. Bacopaside I also exhibits an obvious antidepressant-like effect in mouse model of CUMS-induced depression that was mediated, at least in part, by modulating HPA hyperactivity and activating BDNF signaling pathway. |
| CFN93077 | Cynaropicrin Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-apoptotic activity. Cynaropicrin shows in vivo activity against Trypanosoma brucei. Cynaropicrin possesses immunomodulatory effects on cytokine release, nitric oxide production and immunosuppressive effects. Cynaropicrin also has anti-inflammatory effects, it may participate in the inflammatory response by inhibiting the production of inflammatory mediators and the proliferation of lymphocytes and its inhibitory effect is mediated through conjugation with sulphydryl groups of target protein(s). |
| CFN93078 | Deacylmetaplexigenin Reference standards. |
| CFN93079 | Rhein-8-glucoside Rhein-8-glucoside has low laxative activity. |
| CFN93080 | Nortracheloside Reference standards. |
| CFN93081 | Periplocymarin Periplocymarin, a cardiac glycoside, has potential anti-cancer activity. Octreotide-conjugated periplocymarin demonstrates tumor selectivity and may be useful as a targeting agent to improve the safety profile of cardiac glycosides for cancer therapy. |
| CFN93082 | Panasenoside Reference standards. |
| CFN93083 | Dihydropalmatine Reference standards. |
| CFN93085 | Irisolidone Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 uM. Irisolidone shows anti-inflammatory, anti-platelet aggregation, hepatoprotective, and α-amylase inhibitory activities, it may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion. Irisolidone shows potent inhibitory activity against Helicobacter pylori. Irisolidone also shows antiproliferative activity against amelanotic melanoma cells. |
| CFN93086 | Swertiaperennin Reference standards. |
| CFN93087 | Tribuloside Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity, it can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect. Tribuloside exhibits antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL. |
| CFN93089 | 4-Methyldaphnetin 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.4-Methyldaphnetin inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations. |
| CFN93090 | 5,7-Dihydroxy-4-methylcoumarin 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property, it shows inhibition of the cyclooxygenase pathway. It inhibits human neutrophil oxidative metabolism and elastase activity. |
| CFN93092 | Swertianin Swertianin may be a promising antioxidant, it has potential anti-inflammatory and antinoceceptive which could be used as drug candidates against inflammation related conditions. Swertianin exhibits significant anti-proliferative activity. |
| CFN93093 | Danmelittoside Reference standards. |
| CFN93094 | Uvarigrin Uvarigrin shows cytotoxicity against HCT-8, Bel7402 and A2780 human tumor cell lines at ED50 levels of 0.15, 0.21 and 0.41 microgram/ml, respectively. It induces apoptosis in KBv200 cells and KB cells probably through a mitochondria-dependent pathway. |
