ChemFaces Product List

Catalog No.	Information
CFN70486	Nicotine ditartrate Reference standards.
CFN70487	omega-Benzoyl oxyphloracetophenone Reference standards.
CFN70488	7-Methoxyflavonol Reference standards.
CFN70489	4',6,7-Trimethoxyisoflavone 4',6,7-Trimethoxyisoflavone promotes wound healing through NOX2 induction, which leads to collective migration and MMP activation.
CFN70490	Piperitone Piperitone has insecticidal activity, it inhibited the development of newly laid eggs and of neonate larvae, but was less toxic than the crude extract to individuals developing inside the seeds. Piperitone reduces the nitrofurantoin resistance of strains of enterobacteriaceae.
CFN70491	Pilocarpine Pilocarpine has been used to treat glaucoma, ocular hypertension and xerostomia. Pilocarpine can induce seizures. It antagonizes prostaglandin F2 alpha-induced ocular hypotension in monkeys. the ability of oral pilocarpine to normalise and reverse the salivary biochemical and immunological alterations induced by cGVHD parallels its known stimulatory effect on salivary flow rates. The combination of pilocarpine and sorbitol has effective antimicrobial activity.
CFN70492	4'-Methoxyflavanone Reference standards.
CFN70493	5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone exhibits relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus, it and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity. 5,6,7-Trimethoxyflavone down-regulates the expressions of the pro-inflammatory iNOS, COX-2, TNF-α, IL-1β, and IL-6 genes in macrophages by interfering with the activation of NF-κB, AP-1, and STAT1/3.
CFN95238	3-Acetyl-ginsenoside F1 Reference standards.
CFN95239	Gypenoside XIII Reference standards.
CFN95240	Platycogenin A Reference standards.
CFN95241	Polygalacin D2 Polygalacin D2 may have antimicrobial activity.
CFN91855	Hemiphloin Reference standards.
CFN91854	Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also possesses non-small cell lung carcinoma A549 cell inhibitory activity.
CFN91853	Gypenoside LI Gypenoside LI possesses inhibitory effect on the growth of cancer cells, it induces G2/M arrest.
CFN91852	Regaloside A Regaloside A has anti-inflammatory activity.
CFN91851	Rheumone B Reference standards.
CFN91850	4-O-Cinnamoylquinic acid Reference standards.
CFN91849	2-(2-Phenylethyl)chromone Reference standards.
CFN91848	Sipeimine-3-beta-D-glucoside Reference standards.
CFN91847	Siaresinolic acid 28-O-beta-D-glucopyranosyl ester Reference standards.
CFN91846	4'-hydroxy-6,7,8,3'-tetramethoxyflavonol Reference standards.
CFN91845	Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside Reference standards.
CFN91844	Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B has anti-inflammatory activity.
CFN91843	Regaloside C Regaloside C is anti-inflammatory activities. Regaloside C has cardiomyocyte protective activity by protecting the mitochondria in H2O2-induced heart H9C2 cells.
CFN91842	Regaloside D Regaloside B analogue. Reference standards.
CFN91841	Sibiricose A1 The sibiricosee A1, the sibiricose A5 and the tenuifoliside A have a better treatment function for tristimania caused by various reasons the sibiricose A5 and the tenuifoliside A have a certain protecting function for PC 12 cells damaged by glutamic acid and the sibiricosee A1, the sibiricose A5 and the tenuifoliside A all can shorten the tail-hanging resting time and the swim resting time of a mouse.
CFN91840	(+)-Mediresinol Di-O-beta-D-glucopyranoside Reference standards.
CFN91839	Eupalinolide O Eupalinolide O shows significant anticancer activity, it induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells.
CFN91838	Damulin A Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
CFN91837	Damulin B Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism.
CFN91836	Isofutoquinol A Reference standards.
CFN91835	Achyranthoside C Reference standards.
CFN91834	Achyranthoside D Reference standards.
CFN91833	Hispidulin 4'-O-beta-D-glucopyranoside Reference standards.
CFN60001	SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.
CFN60002	AZD8055 AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
CFN91832	Quercetin-3-O-beta-D-glucopyranosyl-7-O-[(2-O-trans-sinnapoyl)-beat-D-glucopyranosyl(1->6)]-beat-D-glucopyranoside)
CFN91831	Quercetin-3,7-di-O-beta-D-gentiobioside
CFN60003	MK-2206 2HCl MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2.
CFN60004	U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity.
CFN60005	Dabrafenib Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
CFN60006	VE-821 VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.
CFN60007	Venetoclax (ABT-199) Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells.
CFN60008	(+)-JQ1 (+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy.
CFN60009	Romidepsin Romidepsin (FK228, depsipeptide) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.
CFN60010	Pyrazolanthrone (SP600125) SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.
CFN95242	Lappaol B Reference standards.
CFN60011	Y-27632 2HCl Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
CFN60012	Vorinostat(SAHA) Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

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