Natural Products
| Catalog No. | Information |
| CFN70493 | 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone exhibits relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus, it and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity. 5,6,7-Trimethoxyflavone down-regulates the expressions of the pro-inflammatory iNOS, COX-2, TNF-α, IL-1β, and IL-6 genes in macrophages by interfering with the activation of NF-κB, AP-1, and STAT1/3. |
| CFN95238 | 3-Acetyl-ginsenoside F1 Reference standards. |
| CFN95239 | Gypenoside XIII Reference standards. |
| CFN95240 | Platycogenin A Reference standards. |
| CFN95241 | Polygalacin D2 Polygalacin D2 may have antimicrobial activity. |
| CFN91855 | Hemiphloin Reference standards. |
| CFN91854 | Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also possesses non-small cell lung carcinoma A549 cell inhibitory activity. |
| CFN91853 | Gypenoside LI Gypenoside LI possesses inhibitory effect on the growth of cancer cells, it induces G2/M arrest. |
| CFN91852 | Regaloside A Regaloside A has anti-inflammatory activity. |
| CFN91851 | Rheumone B Reference standards. |
| CFN91850 | 4-O-Cinnamoylquinic acid Reference standards. |
| CFN91849 | 2-(2-Phenylethyl)chromone Reference standards. |
| CFN91848 | Sipeimine-3-beta-D-glucoside Reference standards. |
| CFN91847 | Siaresinolic acid 28-O-beta-D-glucopyranosyl ester Reference standards. |
| CFN91846 | 4'-hydroxy-6,7,8,3'-tetramethoxyflavonol Reference standards. |
| CFN91845 | Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside Reference standards. |
| CFN91844 | Regaloside B Regaloside B can inhibit the expression of iNOS and COX-2. Regaloside B has anti-inflammatory activity. |
| CFN91843 | Regaloside C Regaloside C is anti-inflammatory activities. Regaloside C has cardiomyocyte protective activity by protecting the mitochondria in H2O2-induced heart H9C2 cells. |
| CFN91842 | Regaloside D Regaloside B analogue. Reference standards. |
| CFN91841 | Sibiricose A1 The sibiricosee A1, the sibiricose A5 and the tenuifoliside A have a better treatment function for tristimania caused by various reasons the sibiricose A5 and the tenuifoliside A have a certain protecting function for PC 12 cells damaged by glutamic acid and the sibiricosee A1, the sibiricose A5 and the tenuifoliside A all can shorten the tail-hanging resting time and the swim resting time of a mouse. |
| CFN91840 | (+)-Mediresinol Di-O-beta-D-glucopyranoside Reference standards. |
| CFN91839 | Eupalinolide O Eupalinolide O shows significant anticancer activity, it induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells. |
| CFN91838 | Damulin A Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism. |
| CFN91837 | Damulin B Damulin A and Damulin B as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum, which may contribute to beneficial effect of G. pentaphyllum on glucose and lipid metabolism. |
| CFN91836 | Isofutoquinol A Reference standards. |
| CFN91835 | Achyranthoside C Reference standards. |
| CFN91834 | Achyranthoside D Reference standards. |
| CFN91833 | Hispidulin 4'-O-beta-D-glucopyranoside Reference standards. |
| CFN60001 | SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy. |
| CFN60002 | AZD8055 AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1. |
| CFN91832 | Quercetin-3-O-beta-D-glucopyranosyl-7-O-[(2-O-trans-sinnapoyl)-beat-D-glucopyranosyl(1->6)]-beat-D-glucopyranoside) |
| CFN91831 | Quercetin-3,7-di-O-beta-D-gentiobioside |
| CFN60003 | MK-2206 2HCl MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2. |
| CFN60004 | U0126-EtOH U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
| CFN60005 | Dabrafenib Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively. |
| CFN60006 | VE-821 VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ. |
| CFN60007 | Venetoclax (ABT-199) Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. |
| CFN60008 | (+)-JQ1 (+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. |
| CFN60009 | Romidepsin Romidepsin (FK228, depsipeptide) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells. |
| CFN60010 | Pyrazolanthrone (SP600125) SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis. |
| CFN95242 | Lappaol B Reference standards. |
| CFN60011 | Y-27632 2HCl Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| CFN60012 | Vorinostat(SAHA) Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification. |
| CFN60013 | SB203580 SB203580 (RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy. |
| CFN60014 | Imatinib (STI571) Imatinib (STI571) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy. |
| CFN60015 | LY294002 LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis. |
| CFN60016 | Perifosine (KRX-0401) Perifosine (KRX-0401, NSC639966) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3. |
| CFN60017 | Everolimus (RAD001) Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation. |
| CFN60018 | PD98059 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist. |
| CFN60019 | Bortezomib (PS-341) Bortezomib (PS-341, LDP-341, MLM341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors. |
