Natural Products
| Catalog No. | Information |
| CFN70436 | Sennoside A1 Senna leaf is widely consumed as tea to treat constipation or to aid in weight loss, sennoside A, sennoside A1 , and sennoside B are dirheinanthrone glucosides that are abundant and the bioactive constituents in the plant. |
| CFN70437 | Rauhimbine Reference standards. |
| CFN70438 | 8-Acetyl-7-hydroxycoumarin 8-Acetyl-7-hydroxycoumarin shows an interesting activity against V. cholerae, a key bacterium in the contaminated water. |
| CFN70439 | 3',4',5'-Trimethoxyflavone The 3',4',5-trimethoxyflavone derivative and its pharmaceutically acceptable salt inhibit corneal damage through excellent stimulatory action on mucus secretion in the conjunctiva and therefore may be effective as a prophylactic or therapeutic agent for dry eye syndrome. |
| CFN70440 | Veratridine Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production, it also can induce neurotoxicity in rat hippocampal slices. |
| CFN70441 | Pipermethystine Pipermethystine induces mitochondrial toxicity in human hepatoma cells, it is capable of causing cell death, probably in part by disrupting mitochondrial function, thus, it may contribute to rare but severe hepatotoxic reactions to kava. |
| CFN70442 | Leiocarposide Leiocarposide has antiphlogistic and analgesic effects. |
| CFN70443 | Artepillin C Artepillin C shows antioxidant, anti-angiogenesis, and anti-tumor activities; it also shows anti-inflammatory effects mediated, at least in part, by prostaglandin E2 and nitric oxide inhibition through NF-κB modulation. Artepillin C activates the immune system, and possesses direct antitumor activity. Artepillin C can suppress alloreactive CD4 T cell responses in vitro, so it could be used as a potential immunosuppressant, either solely or as adjunct agent in treating graft versus host disease. Artepillin C promotes adipocyte differentiation and glucose uptake in part by direct binding to PPARγ, which could be the basis of the pharmacological benefits of green propolis intake in reducing the risk of type 2 diabetes. |
| CFN70444 | Psoromic acid Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective and safe natural drug plausible for use in controlling tuberculosis infections. Psoromic acid shows antioxidative and cardiovascular-protective activity, it also displays significant apoptotic activities. |
| CFN70445 | Chrysantellin A Reference standards. |
| CFN70446 | 5-Geranoxy-7-methoxycoumarin 5-Geranoxy-7-methoxycoumarin shows antifungal activity. |
| CFN70447 | trans-Fertaric acid Reference standards. |
| CFN70448 | Enterodiol Enterodiol has antioxidant and immunomodulatory effects, it is able to pass the intestinal barrier and modulate cytokine production, it prevented inhibitory-kappaB (I-kappaB) degradation and nuclear factor-kappaB (NF-kappaB) activation, which in turn resulted in decreased tumor necrosis factor-alpha (TNF-alpha) production.Enterodiol inhibited the growth of CRC cells by controlling the MAPK signaling pathway involved in proliferation and apoptosis. |
| CFN70449 | Eclalbasaponin II Eclalbasaponin II induces apoptotic and autophagic cell death through the regulation of JNK, p38, and mTOR signaling in human ovarian cancer cells. It also inhibited NF-κB activation stimulated by TNF-α in a dose-dependent manner, with IC50 values ranging from 8.3 ± 0.7 to 13.5 ± 1.0 μM. Eclalbasaponin II shows antimicrobial activity. Eclalbasaponin II ameliorates cholinergic blockade-induced cognitive impairment via AChE inhibition, LTP formation and the activation of Akt-GSK-3β signaling, and that eclalbasaponin II may be a useful to treat cognitive impairment derived from cholinergic dysfunction. |
| CFN70450 | Enterolactone Enterolactone( Enl ) has chemopreventive action, it suppresses colo 201 human colon cancer cell growth both in vitro and in vivo. Enl may affect the growth of these estrogen sensitive cells is by competition of Enl and its sulfate with the estrogens for sulfokinases and sulfatases involved in estrogen metabolism in the cells. Enl acts as a weak aromatase inhibitor in vitro and to reduce the relative uterine weight of the 7,12-dimethylbenz(a)anthracene-treated nonovariectomized rats. |
| CFN70451 | Tribulosin Tribulosin protects myocardium against ischemia/reperfusion injury through PKCepsilon activation, it also has protective effects on cardiac myocytes against apoptosis induced by H/R injury via PKCϵ and ERK1/2 signaling pathway. |
| CFN70452 | Cucurbitin chloride Reference standards. |
| CFN70453 | 5-O-Methylvisamminol Reference standards. |
| CFN70454 | Solanidine Reference standards. |
| CFN70455 | Negundoside Negundoside exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. Negundoside causes a stimulatory effect on P-glycoprotein (P-gp). |
| CFN70456 | Urushiol (15:2) Reference standards. |
| CFN70457 | Urushiol (15:3) Reference standards. |
| CFN70458 | Shatavarin IV Shatavarin IV shows in vitro anti-malassezia activity. Shatavarins (containing shatavarin IV) rich fraction (AR-2B) exhibits significant anticancer activity in both in vitro and in vivo experimental models. |
| CFN70459 | Acetoxyvalerenic acid Acetoxyvalerenic acid may have anxiolytic activity. |
| CFN70460 | Cinnamtannin A2 Cinnamtannin A2 may increase the production of mature form SREBPs and LDL receptor activity, thereby increasing ApoA1 and decreasing ApoB levels. |
| CFN70461 | Dodeca 2E,4E,8Z,10E,Z-tetraenoic acid isobutylamide Dodeca 2E,4E,8Z,10E,Z-tetraenoic acid isobutylamide exhibits potent anti-oxidant property. |
| CFN70462 | Gossypetin 3-methylether Reference standards. |
| CFN70463 | Furanoeudesma 1,3-diene Reference standards. |
| CFN70464 | 8-p-Coumaroylharpagide 8-p-Coumaroylharpagide shows analgesic and anti-inflammatory properties. |
| CFN70465 | Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes. |
| CFN70466 | Manassantin B Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in part, via inhibition of cell proliferation and decrease of collagen production. |
| CFN70467 | 8-Acetyl-7-methoxycoumarin Reference standards. |
| CFN70468 | Luteolin 7-diglucuronide Luteolin-7-diglucuronide( L7DG) is pharmacologically effective in protecting the heart against developing ISO-induced injury and fibrosis, justifying further evaluation of L7DG as a cardioprotective agent to treat related cardiovascular diseases. |
| CFN70469 | 5,7-Dihydroxy 3,3',4',5',6,8-hexamethoxyflavone Reference standards. |
| CFN70470 | Qingdainone Qingdainone is active in test on melanoma B, it also shows inhibitory action against Lewis lung carcinoma in mice. |
| CFN70471 | Gardenin A Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, but not TrkA-dependent, CREB signaling pathways in PC12 cells. |
| CFN70472 | 4,4'-Dimethoxychalcone Reference standards. |
| CFN70473 | 3,4-Dihydroxy-5-methoxybenzoic acid |
| CFN70474 | 5-Methoxyflavone |
| CFN70475 | 3,5-Dihydroxy-4-methoxybenzoic acid 3,5-dihydroxy-4-methoxybenzoic acid is a COMT inhibitor. |
| CFN70476 | (-)-Eburnamonine (-)-Eburnamonine induced a superior improvement than Papaverine of some clinical symptoms (motor disorders, retrograde amnesia, vertigo) and of cortical bioelectrical activity. (-)-Eburnamonine enhanced the affinities for carbachol, bethanechol, furmethide, methylfurmethide, pentylthio-TZTP, pilocarpine, oxotremorine and oxotremorine-M on the M2 receptors. |
| CFN70477 | 7-Hydroxyflavonol 7-Hydroxyflavonol can inhibit E6 binding to FADD and caspase 8. |
| CFN70478 | Quinidine sulfate Quinidine sulfate has antiarrhythmic efficacy. Quinidine is a non-specific ionic channel blocker that inhibits all the membrane currents in the atrioventricular node including the acetylcholine-activated K+ current. |
| CFN70479 | Apioline Reference standards. |
| CFN70480 | Eugenol benzoate Eugenol benzoate, a potent lipoxygenase inhibitor, has antioxidant activity. |
| CFN70481 | 3,4-Dimethoxychalcone Reference standards. |
| CFN70482 | Phloroglucinol aldehyde triethylether Reference standards. |
| CFN70483 | Papaverine hydrochloride Papaverine hydrochloride can used in an effective manner in the management of renal colic pain in patients unresponsive to commonly used conventional agents. Papaverine hydrochloride has a potent inhibitory effect on the replication of viruses such as cytomegalovirus (CMV) and measles, it has an inhibitory effect on mitogenic responses. |
| CFN70484 | Rauwolscine hydrochloride Rauwolscine hydrochloride is an alpha 2-receptor antagonist. |
| CFN70485 | Carvacryl acetate Carvacryl acetate, a TRPA1 receptor agonist, which has anti-inflammatory, antioxidant, anxiolytic-like, and anti-epilepsy activities. It exhibited anti-inflammatory activity in mice by reducing inflammatory mediators, neutrophil migration and cytokine concentration, and anti-nociceptive activity due to the involvement of capsaicin and glutamate pathways. Carvacryl acetate seems to have an anxiolytic-like effect, probably due to GABAergic agonist action, without psychomotor side effects. Carvacryl acetate also shows neuropharmacological effects on δ-aminolevulinic dehydratase, Na+, K+-ATPase activities and amino acids levels in mice hippocampus after seizures. Carvacryl acetate at 6.25 μg/mL has antischistosomal activity. |
