Natural Products
| Catalog No. | Information |
| CFN70339 | Artemicapin C Reference standards. |
| CFN70340 | Homobutein Homobutein as a dual inhibitors of HDACs and NF-κB, it can serve as a lead compound in the development of dual inhibitors against both targets in the treatment of inflammation and cancer. Homobutein shows antioxidant and antimalarial properties based on its ability to chelate iron (II and III) cations. |
| CFN70341 | Tryptamine hydrochloride Tryptamine hydrochloride has antioxidative effects. |
| CFN70342 | 3',4',7,8-Tetrahydroxyflavone 3',4',7,8-Tetrahydroxyflavone inhibits osteoclast differentiation and bone loss and may therefore be considered a promising drug candidate for treating or preventing bone-lytic diseases. 3',4',7,8-Tetrahydroxyflavone exhibits antibacterial activity against S. mutans. It can absorb UV light and form photooxidation derivatives. |
| CFN70343 | Vitexin 7-glucoside Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo. |
| CFN70344 | Urushiol (15:1) Reference standards. |
| CFN70345 | 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone can markedly augment TRAIL-induced apoptosis and cytotoxicity in LNCaP cells. |
| CFN70346 | 2',6'-Dihydroxy 4'-methoxydihydrochalcone 2′,6′-Dihydroxy-4′-methoxydihydrochalcone exhibited potent antiplasmodial activity with IC50 values of12.69 μM against both chloroquine-sensitive and resistant strains of Plasmodium falciparum (F32, FcB1). |
| CFN70347 | Eupalitin 3-galactoside Eupalitin-3-O-β-D-galactoside(Eupalitin 3-galactoside) has anti-inflammatory effects, it in Conconavalin-A induced koi carp possibly through inhibition of NFkB and p38 MAPK that mediates the expression of pro inflammatory cytokine TNF-α. |
| CFN70348 | Caffeoyl alcohol Reference standards. |
| CFN70349 | Vescalagin Vescalagin acts as a preferential catalytic inhibitor of the α isoform of human DNA topoisomerase II. Vescalagin has hypotriglyceridemic and hypoglycemic efects, it could have therapeutic value against diabetic progression. |
| CFN70350 | Withanoside IV Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury. Withanoside IV may prevent or decrease the growth of tumors in human. Withanoside IV showed significant neurite outgrowth activity at a concentration of 1 μM on a human neuroblastoma SH-SY5Y cell line. Withanoside IV (10 micromol/kg/day) significantly improved memory deficits in Abeta(25-35)-injected (25 nmol, i.c.v.) mice and prevented loss of axons, dendrites, and synapses. |
| CFN70351 | 6,7-Dihydroxyflavone 6,7-Dihydroxyflavone has fee radical scavenging activity. 6,7-Dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA). |
| CFN70352 | Daidzein 7-O-glucuronide Daidzein-7-O-glucuronide has estrogenic potency. |
| CFN70353 | Genistein 7-O-glucuronide Genistein 7-O-glucuronide has estrogenic potency. |
| CFN70354 | Caffeoylmalic acid Caffeoylmalic acid has neurosedative and antioxidant activities. |
| CFN70355 | Trioxsalen Trioxsalen, a toxic component, has tumorigenic property. Trioxsalen derivative 3 can significantly inhibit LOX, with IC(50) 9.4 muM, it has analgesic and anti‐inflammatory effects. |
| CFN70356 | Cupressuflavone Cupressuflavone has hepatoprotective, analgesic and anti‐inflammatory effects. Cupressuflavone could exert a beneficial effect against oxidative stress by enhancing the antioxidant defense status, reducing lipid peroxidation, and protecting against the pathological changes induced by CCl4 in the liver and kidney tissues. |
| CFN70357 | trans-Aconitic acid Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max.Trans-aconitic acid has antileishmanial activity ,the diesters of TAA as potential useful derivatives for the management of rheumatoid arthritis and other inflammatory diseases. |
| CFN70358 | Harmol hydrochloride monohydrate Reference standards. |
| CFN70359 | 3',4'-Dimethoxyflavone 3′,4′-Dimethoxyflavone is a widely used anticancer drug that acts as a competitive antagonist of the aryl hydrocarbon receptor. |
| CFN70360 | 3',4'-Dihydroxyflavone 3',4'-Dihydroxyflavone shows anti-inflammatory activity, which might be related to suppression of the proinflammatory MAPK and NF-κB signaling pathways. 3',4'-Dihydroxyflavone can inhibit parasitophorous vacuole formation, modulate glial cell responses, increase NO secretion, and interfere with N. caninum infection and proliferation. |
| CFN70361 | 4'-Methoxyflavone 4'-Methoxyflavone can inhibit the modulation of the chemiluminescent capacity of macrophages. |
| CFN70362 | Umckalin Umckalin shows antibacterial activity. Umckalin has antitubercular activity, it exhibited MIC values of 62.5 µg/mL against M. smegmatis. |
| CFN70363 | Syringetin Syringetin prevents and treats bone metastasis in patients with lung cancer, it can directly inhibits osteoclastogenesis and reverses lung adenocarcinoma‑mediated osteoclastogenesis. Syringetin can increase BMP-2 synthesis, and subsequently activate SMAD1/5/8 and ERK1/2, and this effect may contribute to its action on the induction of osteoblast maturation and differentiation, followed by an increase of bone mass. |
| CFN00509 | Phyllalbine |
| CFN70364 | Gitoxin Gitoxin may offer a potential treatment for drug resistant NSCLC.It inhibited the phosphorylation of Erk1/2 in a dosage and time dependent way. |
| CFN00510 | Lupinine |
| CFN70365 | Larixyl acetate Larixyl acetate exhibits analgesic and anti-inflammatory action in neuropathic pain, the action involves the suppression of TRPC6 and p38 signaling in the microglia. |
| CFN70366 | Capsanthin Capsanthin has antioxidant activity. |
| CFN70367 | Marrubiin Reference standards. |
| CFN70368 | Proscillaridin A Proscillaridin A is a cardiac glycoside, it has anticancer, analgesic effects and immunoreactivities. Proscillaridin A induces apoptosis in MDA-MB-231 cells by increasing free calcium concentration and by activating caspase-3. It exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma. |
| CFN70369 | Grayanotoxin I Grayanotoxin I has an inhibitory effect on the initiation of action potentials of fibers of both muscles. This toxin causes a gradual decrease of the resting potential and an elevation of the critical firing level. |
| CFN70370 | beta-Cryptoxanthin beta-Cryptoxanthin has a stimulatory effect on cell proliferation and biochemical components in osteoclastic MC3T3-E1 cells, and that the carotenoid can stimulate transcriptional activity in the cells. |
| CFN70371 | Demissidine Demissidine can induce programmed cell death. |
| CFN70372 | Sanguinarine nitrate Sanguinarine nitrate shows strong activity on Gram-negative bacteria. |
| CFN70373 | 2',3,5,7-Tetrahydroxyflavone 2',3,5,7-Tetrahydroxyflavone inhibits MMP-13 expression in IL-1β-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways. |
| CFN70374 | Calycopterin Calycopterin, an immunoinhibitory compound, it possesses potent antiangiogenic activities, which may be due to its inhibitory influences on VEGF expression. Calycopterin promotes survival and outgrowth of neuron-Like PC12 cells by attenuation of oxidative- and ER-stress-induced apoptosis along with inflammatory response. Calycopterin shows anticancer effect, the effect via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and mitochondrial dysfunction in hepatoblastoma cancer (HepG2) cells. |
| CFN70375 | Corynanthine Corynanthine is an alpha 1-adrenoceptor and alpha 2-adrenoceptor antagonist. Corynanthine inhibits, while idazoxan potentiates, cardiotoxic effects of ouabain. It modulates DNA synthesis in mitogen-stimulated human lymphocytes. |
| CFN70376 | 3',4',7-Trihydroxyisoflavone 3',4',7-Trihydroxyisoflavone has antioxidant, estrogenic, and chemoprotective activities, it inhibits the CK-II-mediated phosphorylation of 60S acidic ribosomal P proteins in vitro. CDKs and PI3K are the primary molecular targets of 3',4',7-Trihydroxyisoflavone in the suppression of EGF-induced cell proliferation. 3',4',7-Trihydroxyisoflavone nanoparticles are characterized by improved physicochemical properties, increased water solubility, and enhanced skin penetration, and these may have potential use in the future as a topical delivery formulation for the treatment of skin diseases. |
| CFN70377 | (+)-Dihydrocinchonine Reference standards. |
| CFN70378 | 7-Hydroxy-4'-methoxyflavone Reference standards. |
| CFN70379 | Fumarprotocetraric acid Fumarprotocetraric acid has expectorant, antioxidant, antimicrobial , and allelopathic properties. It shows inhibitory activity against enzymes such as tyrosinase, a key agent in melanin biosynthesis. |
| CFN70380 | Protocetraric acid Protocetraric acid demonstrates a strong antioxidant, antimicrobial, and anticancer effects. |
| CFN70381 | Maritimein Reference standards. |
| CFN70382 | Isogentisin Isogentisin has mutagenic activity, it also shows MAO inhibition. Isogentisin showed antimicrobial activity with MIC values ranging from 117–310µg/ml. |
| CFN70383 | Dhurrin Reference standards. |
| CFN70384 | Nordihydroguaiaretic acid Nordihydroguaiaretic acid(NDGA), an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes. NDGA has anti-inflammatory, antimutagen and/or anticarcinogen activities. NDGA protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation, it can interupt a neurodegenerative pathway relevant to the pathophysiology of Alzheimer's disease. NDGA protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice. NDGA-crosslinking of decellularized valvular matrix is a promising approach for preparation of heart valve tissue engineering scaffolds. |
| CFN70385 | Convallatoxin Convallatoxin, one cardiac glycoside, is a novel anti-angiogenic compound via dual inducing of autophagy and apoptosis, it shows antitumor effects that harbor inactivating mutations in the p53 signaling pathway. Convallatoxin as a novel antiviral, limiting mRNA translation has a dramatic impact on CMV infection and proliferation. Convallatoxin also anti-diabetic activity. |
| CFN70386 | Cymarin Cymarin exhibits potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210). |
