Natural Products
| Catalog No. | Information |
| CFN98666 | 14-Deoxy-11,12-didehydroandrographolide 14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions, it causes negative chronotropic action and antagonised isoproterenol-induced positive chronotropic actions in a non-competitive and dose-dependent manner. 14-Deoxy-11,12-didehydroandrographolide can effectively ameliorate astrocytic pro-inflammatory reactions and prevent PC12 cell death with different efficacies, it may be candidates for treatment of spinal-cord injury and neurodegeneration. |
| CFN98658 | Trilobatin Trilobatin has anti-oxidant, and anti-inflammatory effects, it can increase superoxide dismutase (SOD) activity, and it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway. Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect. |
| CFN98656 | Acuminatin (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively.(-)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents. |
| CFN98650 | Koaburaside monomethyl ether Standard reference |
| CFN98643 | Skullcapflavone I Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I selectively induces apoptosis in T-HSC/Cl-6 cells via caspase-3 and caspase-9 activation. |
| CFN98565 | Luteolin-7-O-glucoside Luteolin-7-O-glucoside has cardioprotective, anti-asthmatic, anticancer, anti-inflammatory, and antioxidative activities, it can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.Luteolin-7-O-glucoside modulated the Nrf2/MAPK/ PTEN/Akt /ERK/AP-1/PI3K-Akt signaling pathways, it suppressed the expression of β-catenin. |
| CFN98563 | Notopterol Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities, it shows significant antiproliferative activity against the HepG-2, MCF-7 and C6 cancer cell lines. |
| CFN98623 | Nuezhenide Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage. It significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity. |
| CFN98620 | Isovitexin Isovitexin, a food phytochemical contained in dietary rice products, it exhibits in vivo α-glucosidase inhibition, it possesses antihyperglycemic, neuroprotective, anti-inflammatory and anti-oxidant activities. Isovitexin inhibited xanthine oxidase with an IC50 value of 15.2 microM, it may protect cells from oxidative stress. It inhibited JNK, MAPK and NF-κB and activated HO-1/Nrf2 pathways. |
| CFN98612 | Cimifugin Cimifugin evidently inhibits FITC-induced type 2 allergic contact dermatitis,and its mechanism might related to regulating the balance of Th1 /Th2 by inhibiting type 2 cytokines. Cimifugin displayed low to moderate inhibition towards AChE and BChE (3.12 and 21.63%, respectively) at 200 ug/mL. |
| CFN98604 | Murrangatin Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein–Barr virus early antigen (EBV–EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277). Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1β, tumor necrosis factorα, prostaglandins E2,and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2. |
| CFN98601 | Vitexin Vitexin, an HIF-1alpha inhibitor, which has anticonvulsant, anti-depressant, anti-glycation, spasmolytic, anti-metastatic, antitumor, anti-inflammatory and antinociceptive activities. Vitexin can be effectively used for the prevention of UV-induced adverse skin reactions such as free radical production and skin cell damage; it non-competitively inhibits Ach but not the Ca(2+) influx. |
| CFN98546 | Lithospermic acid Lithospermic acid has anti-HIV, antioxidant ,anti-inflammatory, and hepatoprotective effects, is a competitive inhibitor of xanthine oxidas (XO), can directly scavenge superoxide and inhibit superoxide production in vitro, and presents hypouricemic actions in vivo. Lithospermic acid has inhibitory effects on proliferation and migration of rat vascular smooth muscle cells, it has a preventive effect on the development of diabetic retinopathy. Lithospermic acid can attenuate 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways. Lithospermic acid can attenuate mesenteric ischemia reperfusion injury in rat intestines by increasing tissue SOD and GPx activities and decreasing MDA and MPO levels, also improves morphological alterations which occurred after periods of reperfusion. |
| CFN98545 | Bufotaline Bufotalin is a cardiotoxic bufanolide steroid, cardiac glycoside analogue. Bufotalin has anti-cancer activity, it can induce apoptosis in Hep 3B cells, and caspase-8 inhibitor (Z-IETD) or wide-ranging caspase inhibitor (Z-VAD) significantly suppresses the bufotalin-induced apoptosis. Bufotalin is a powerful sensitizer of death receptor-induced apoptosis in cancer cells, it promotes death receptor-mediated cell death, especially TRAIL-induced apoptosis, through activation of caspase-3 and PARP-1. |
| CFN98498 | beta-Costic acid The use of costic acid and other components from the plant Dittrichia viscosa (Greek: aconiza) and related species for the preparation of acaricidal products used against the acari Varroa destructor as parasite of the honey bee. |
| CFN98544 | Cinobufagin Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer, it also has anti-hepatitis B virus activity . Cinobufagin inhibits the proliferation and induces apoptosis, may be related to the mitochondria-mediated pathway and GSK-3β/NF-κB pathway. Cinobufagin can significantly relieve cancer pain in mice and raised their pain threshold, mainly upregulating the expression levels of β -END and μ -OR in the hind paw tumor and adjacent tissue.Cinobufagin and bufalin exhibit cardiotonic and natriuretic activities, they also have inhibitory effects on steroidogenesis of aldosterone and cortisol. |
| CFN98540 | Oroxylin A Oroxylin A has anticancer,.anti-inflammation, antithrombotic,antibacterial, anti-pruritic effects, it can inhibit LPS-induced iNOS and COX-2 gene expression by blocking NF-κB activation. Oroxylin A reverses MDR by G2/M arrest and the underlying mechanism attributed to the suppression of P-gp expression via Chk2/P53/NF-κB signaling pathway. Oroxylin A facilitates memory consolidation through brain-derived neurotrophic factor (BDNF)-TrkB signaling. |
| CFN98539 | Anwulignan Anwuligan has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities. (+)-Anwulignan has inhibitory effects on platelets aggregation induced by adenosine diphosphate (ADP) and platelet activating factor(PAF) in vitro. |
| CFN98531 | Miltirone Miltirone is a CYPs inhibition, it has been characterized as a low-affinity ligand for central benzodiazepine receptors, it might ameliorate the symptoms associated with discontinuation of long-term administration of ethanol or of other positive modulators of the GABA A receptor. Miltirone possesses significant anticancer, antibacterial, antioxidant, and anti-inflammatory activities, the hepatocyte metabolism is the major route of clearance for miltirone. Miltirone is collateral sensitive in multidrug-resistant P-gp-overexpressing cells, induces G2/M arrest, and triggeres apoptosis via ROS-generated breakdown of MMP and DNA damage. Miltirone has antiprotozoal activity against T. brucei rhodesiense STIB 900. |
| CFN98489 | Alpinetin Alpinetin has antibacterial, anti-inflammatory, and anti-cancer activities; it inhibits proliferation ,regulates of the Bcl-2 family and XIAP expression, releases of cytochrome c and activates caspases. |
| CFN98488 | 2',4'-Dihydroxy-6'-methoxyacetophenone 2,4-Dihydroxy-6-methoxyacetophenone exhibits a moderate antispasmodic activity. |
| CFN98483 | Vestitol Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemical barrier against the intrusion of the parasite. |
| CFN98525 | Baohuoside I Baohuoside I is a novel immunosuppressive molecule, exhibits antimetastatic, anti-osteoporosis, anti-inflammatory and anti-cancer activities. Baohuoside I can inhibit the proliferation of Eca-109 cells, this effect associats with down-regulation expression of β-catenin,Cyclin D1,Survivin,and their proteins,which affects on the Wnt/β-catenin signaling pathway. |
| CFN98524 | Genipin-1-O-gentiobioside Reference standards. |
| CFN98467 | 9-Hydroxycalabaxanthone 9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α-mangostin shows the synergistic antimalarial interaction in both clones. |
| CFN98466 | Pinosylvin monomethyl ether Pinosylvin monomethyl ether (E)-3-Hydroxy-5-methoxystilbene possesses inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among others. |
| CFN98464 | Ziyuglycoside I Ziyuglycoside I has anti-wrinkle activity, could be used as an active ingredient for cosmetics. |
| CFN98519 | Buddlejasaponin IV Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation. Buddlejasaponin IV exerts cytotoxic effects against cancer cells,it can induce cell cycle arrest at G2/M phase and apoptosis in immortalized human oral keratinocytes, it may possess antimetastatic potential by inducing anoikis and upregulating NAG-1 expression. Buddlejasaponin IV can inhibit intrinsic and extrinsic hyperlipidemia and hypercholesterolemia in the rat. |
| CFN98456 | 1-Methoxycarbonyl-beta-carboline 1-Methoxycarbonyl-beta-carboline is a nantural product from Ailanthus altissima. |
| CFN98454 | Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.Nortrachelogenin has anti-inflammatory properties,it shows moderate inhibiting activities on NF- κB signaling pathway induced by TNF-α , with the IC50 value of 49.4 uM. Nortrachelogenin also shows anti-plasmodium activity of 14.50 dg/ml. (+ )-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits, it is moderately active against HIV-1 in vitro. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane, it also can induce membrane disruption and caspase-dependent apoptosis. |
| CFN98512 | Luteolin-7-O-glucuronide Luteolin-7-O-glucuronide has anti-inflammatory activity. Luteolin 7-O-glucuronide shows potent α-glucosidase inhibitory effect with IC50 values of 14.7 uM, it also exhibits moderate α-amylase activity with IC50 values 61.5uM.Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
| CFN98453 | Prudomestin Standard reference |
| CFN98451 | Lyoniside Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The synergistic action of lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris. |
| CFN98508 | Ginkgolic acid C17:1 Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. |
| CFN98504 | (-)-Catechin gallate(CG) (-)-Catechin gallate is a minor constituent in green tea catechins, it inhibits the activity of COX-1 and COX-2 enzymes. Catechin gallate (IC50=53 microM) shows cytotoxicity against the colorectal adenocarcinoma cell line HCT116, it also exhibits strong anti-proliferative and anti-inflammatory activities on pancreatic ductal adenocarcinoma (PDAC) cells. Catechin 3-gallate is a good inhibitor of maltase, with IC50 values of 62 uM, it inhibits both α-glucosidases and rabbit glycogen phosphorylase (GP) in vitro and in cell culture, would contribute to the protection or improvement of type 2 diabetes. |
| CFN98433 | Pachypodol Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata. Pachypodol has cytotoxic potential , it can inhibit the growth of CaCo 2 colon cancer cell line in vitro. Pachypodol exhibits anti-emetic effects. |
| CFN98429 | Quercetin 3,4'-dimethyl ether Quercetin 3,4’-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4’-dimethyl ether could be useful in the development of novel anticancer agents, it has high cytotoxic against leukemia cells, it induces cell death is mediated by an intrinsic dependent apoptotic event involving mitochondria and MAPKs, and through a mechanism independent of the generation of reactive oxygen species. |
| CFN98427 | 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced β-amyloid (Aβ) aggregation, it has multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD. 8-Deoxygartanin has antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. 8-Deoxygartanin has cytotoxic effect on human melanoma cells, it inhibits p65 activation with IC50 values of 11.3 microM, it is a potential candidate as anti-melanoma agents. |
| CFN98419 | Cajanin Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug. Cajanin has strong mitogenic as well as differentiation-promoting effects on osteoblasts that involved subsequent activation of MEK-Erk and Akt pathways. |
| CFN98416 | Oleuropein Oleuropein exhibits anti-ischemic, antioxidative, hypolipidemic, in vitro antimycoplasmal , anti-inflammatory, and anti-cancer effects., it also may be helpful in the prevention of diabetic complications associated with oxidative stress. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion, and reduces viremia in duck hepatitis B virus (DHBV)-infected ducks. Oleuropein reduces TLR and MAPK signaling. |
| CFN98500 | Apigenin-7-glucuronide Apigenin-7-glucuronide possesses multiple pharmacological activities, including anti-oxidant, anti-complement, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. Apigenin 7-O-β-D-glucuronide protects mice from LPS-induced endotoxin shock by inhibiting proinflammatory cytokine production, it may be used as a dietary complement for health promotion. |
| CFN98411 | Medicarpin Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERβ, promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in addition, given its excellent oral bioavailability, it can be potential osteogenic agent. Medicarpin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway. Medicarpin also has antifungal activity. |
| CFN98404 | Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. |
| CFN98403 | 6-Methoxywogonin 6-Methoxywogonin shows weak anti-inflammatory effect. |
| CFN98402 | Heraclenol Heraclenol is a germination inhibitor in the parsley seeds. It has anti-inflammatory properties against the ear edema in mice produced by TPA. Heraclenol and heraclenin inhibit the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 uM. |
| CFN98400 | Isobavachin Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells. |
| CFN98397 | Arjunic acid Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL. |
| CFN98396 | gamma-Mangostin gamma-Mangostin is a dual agonist that activates both PPARδ and PPARα, is also a novel competitive antagonist for the 5-HT2A receptors in vascular smooth muscles and platelets.gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells, and exhibits antihypertensive, anti-inflammatory, analgesic effects. gamma-Mangostin could as a preventive agent of the metabolic syndrome, and could serve as a micronutrient for colon cancer prevention. |
| CFN98391 | Magnolin Magnolin has anti-inflammatory, anti-histaminic, and antioxidative effects, it might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2. Magnolin can ameliorate the renal tubular necrosis, apoptosis, and the deterioration of renal function, it reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. |
| CFN98373 | Amygdalin Amygdalin has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and better than the single use of Amygdalin or HSYA. Amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax. |
