Natural Products
| Catalog No. | Information |
| CFN90213 | Telocinobufagin Telocinobufagin is a novel endogenous digitalis, it shows a reversible local anesthetic action, similar to BUPI, however, without cardiac toxicity in vitro. Telocinobufagin has antimicrobial, potential immune system regulatory effects, it could be developed as a novel immunotherapeutic agent to treat and other immune-mediated diseases, and it may become a new immunomodulatory agent in many regions. |
| CFN90211 | Sagittatoside B Sagittatoside B is a natural product from Epimedium brevicornu Maxim. |
| CFN97549 | (-)-Epigallocatechin(EGC) (-)-Epigallocatechin exhibits antiplatelet,anticoagulation,anti-tumor,anti-cancer and anti-inflammatory functions. Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2. Cu(2+) with (-)-epigallocatechin (EGC) facilitated DNA cleavage, while Ag+ with EGC showed a strong repressive effect. |
| CFN90209 | Cucurbitacin D Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. Cucurbitacin D may be a potential therapeutic agent for β-hemoglobinopathies, including sickle cell anemia and β-thalassemia. Cucurbitacin D is a new inflammasome activator in macrophages, it can initiate immunomodulating activity in macrophages to lead to inflammasome activation as well as enhancement of LPS signaling. |
| CFN90208 | Polygalaxanthone III Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1. |
| CFN90198 | Alisol A 24-acetate Alisol A 24-acetate has antibacterial activity, it also has anti-complement activity against the classical pathway of the complement system with IC50 values of 130 microM. Alisol A 24-acetate can effectively prevent bone loss in ovariectomized (OVX) mice, and that it can be considered a potential therapeutic for the treatment of postmenopausal osteoporosis. |
| CFN90197 | Schaftoside Schaftoside has antioxidant activity, it also can inhibit phospholipase, lipoxygenase and cyclooxygenase, three pro-inflammatory enzymes. |
| CFN90196 | Corydaline Corydaline is an acetylcholinesterase inhibitor, is also an inhibitor of CYP2C19 and CYP2C9. Corydaline has antiallergic, and antinociceptive activities. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. |
| CFN90193 | Gypenoside XVII Gypenoside XVII confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, inactivation of GSK-3β and activation of Nrf2/ARE/HO-1 pathways. Gypenoside XVII has protective effects to the cellular and rodent models of Alzheimer's disease by activating TFEB. |
| CFN90192 | 1,2,3,4,6-O-Pentagalloylglucose 1,2,3,4,6-O-Pentagalloylglucose(PGG) has antimutagenic, anti-proliferative, anti-invasive,vasodilatory, anti-inflammatory, anti-parasitic, anti-HBV, and antioxidant activities. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. PGG dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling; it also has inhibition of inducible NO synthase and cyclooxygenase-2 activity. |
| CFN97542 | Isoliquiritigenin Isoliquiritigenin has hepatoprotective, chemopreventive, antitumor, vasorelaxant, anti-platelet, anti-allergic, antiviral, antioxidant and anti-inflammatory effects, it can induce growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. Isoliquiritigenin also has the ability to protect cells from AA+iron-induced H2O2 production and mitochondrial dysfunction, which is mediated with GSK3β phosphorylation downstream of AMPK. |
| CFN90191 | Oroxylin A 7-O-beta-D-glucuronide Oroxylin A-7-O-glucuronide and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM) products of radix Scutellariae.. Oroxylin A 7-O-glucuronide can inhibit total prolyl oligopeptidase (POP) activity. |
| CFN90190 | Eupatilin Eupatilin has anti-inflammatory, and anti-tumor properties, it inhibits the MKN-1 gastric cancer cell proliferation via activation of caspase-3 and the metastatic potential of gastric cancer cells via down-regulation of NF-κB activity followed by reduction of pro-inflammatory cytokine-mediated MMPs expressions. Eupatilin inhibits the signalling of MAPK, IKK, NF-κB and eotaxin-1 in bronchial epithelial cells, leading to inhibition of eosinophil migration. Eupatilin is also a promising therapeutic agent against acute ischemia-induced renal damage, it significantly increases the levels of heat shock protein 70 and B-cell lymphoma protein, and it attenuates inducible nitric oxide synthase, Bcl-2-associated X protein, and caspase-3 levels. |
| CFN90185 | Columbianetin Columbianetin is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. Columbianetin has anti-inflammatory effects, it promotes histamine release, and inhibits the histamine release by substance P, suggests that it may be helpful in regulating mast cell-mediated allergic inflammatory responses. (2'S)-columbianetin can be effectively used to protect keratinocytes from UVB induced damage. |
| CFN90184 | Hederacoside D Hederacoside D is a narural product from Hedera nepalensis. |
| CFN90183 | Hederacoside C Hederacoside C is one of the active ingredients in Hedera helix leaf extract (Ivy Ex.) and AG NPP709, a new botanical drug to treat acute respiratory infection and chronic inflammatory bronchitis. Hederacoside C has antispasmodic activity. Hederacoside C is a potent competitive inhibitor for serine protease porcine pancreatic elastase, shows comparable IC 50 value is 40.6 uM; it also non-competitively inhibits hyaluronidase activity in a dose- dependent fashion, shows comparable IC 50 value is 280.4 uM. |
| CFN90181 | Isofraxidin Isofraxidin has definite anti-bacterial, anti-oxidant, analgesic,and anti-inflammatory activities, it inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines.Isofraxidin is one possible radio-protector, it can protect leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. |
| CFN90178 | Nardosinone Nardosinone is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. It has a wide spectrum of targets including PI3K,Akt,MEK,ERK, PKA, MAPK. |
| CFN90176 | Corilagin Corilagin has antitumour, anti-inflammatory, antioxidant, antifibrotics, antiviral, antibacterial, hepatoprotective, antiatherogenic, and antihypertensive activities. Corilagin reduces the cytotoxicity induced by EV71 or CA16 on Vero cells with and IC50 value of 5.6 and 32.33 μg/mL, respectively; it shows the potential to protect against HSV-1-induced encephalitis, and the beneficial effects may be mediated by inhibiting TLR2 signaling pathways. Corilagin attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling; it suppresses the activity of beta-lactamase to some extent. |
| CFN97522 | Sappanchalcone Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor. Sappanchalcone has cytoprotective, and anti-inflammatory effects, it could be used as an anti-inflammatory and bone-protective agent during the treatment of rheumatoid arthritis. Sappanchalcone blocks cell cycle progression in the G2/M phase, it suppresses oral cancer cell growth and induces apoptosis through the activation of p53-dependent mitochondrial, p38, ERK, JNK, and NF-κB signaling, could potentially used to treat periodontal, pulpal , periapical inflammatory lesion and oral cancer. Sappanchalcone possesses the most potent effect against allergic reaction in basophilic leukemic (RBL-2H3) cells with an inhibitory concentration (IC50) value of 7.6 uM, it may have anti-allergic activity. |
| CFN90174 | Isoginkgetin Isoginkgetin is a MMP-9 inhibitor, also a pre-mRNA splicing inhibitor with IC 50 of 30 uM. Isoginkgetin can up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. Isoginkgetin has anti-tumor activity, it can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. |
| CFN90173 | Ginkgetin Ginkgetin is a good STAT3 inhibitor , which has anti-inflammatory, neuroprotective, anti-influenza virus and anti-fungal activities. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. |
| CFN90172 | Gambogic acid Gambogic acid is a tissue-specific proteasome inhibitor, which has anticancer, anti-inflammatory, and anti-angiogenesis activities. Gambogic acid induces LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) upregulation, which is responsible for EGFR (epidermal growth factor receptor) degradation and its downstream Akt/mTORC1 inhibition. |
| CFN90171 | Polygalasaponin F Polygalasaponin F possesses anxiolytic and sedative-hypnotic activities, and has cognition improving and cerebral protective effects. Polygalasaponin F can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. |
| CFN90167 | Rubusoside Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.Rubusoside can improve the survival rate of palmitic acid- induced INS- 1 cells and inhibit the occurrence of apoptosis. |
| CFN90166 | Physalin L Physalin L shows a distinct fluorescence spot under UV 365 nm with good separation. |
| CFN90164 | Dimethylacrylshikonin Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors, it inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. Dimethylacrylshikonin inhibits agonist-induced relaxation at lower concentrations and induces vasocontraction at higher concentrations. |
| CFN97498 | Cucumegastigmane I Standard reference |
| CFN97494 | Scopoletin Scopoletin exhibits antifungal, anti-allergic, anti-aging, and hypouricemic activities, it exerts anti-RA action probably through suppressing IL-6 production from fibroblast-like synoviocytes via MAPK/PKC/CREB pathways. Scopoletin can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet. |
| CFN97488 | Viscidulin III Viscidulin III (17.4 microM), wogonin (17.4 microM) and luteolin (18.4 microM) were more effective than baicalein (23.0 microM) which reportedly inhibits the proliferation of some cancer cell lines. |
| CFN97472 | Neochlorogenic acid Neochlorogenic acid shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia. |
| CFN90160 | Methysticin Methysticin is a potent NF-kappaB inhibitor in kava with minimum toxicity, it possesses hepatotoxic, anticonvulsant and neuroprotective properties, it contributes to CYP1A1 induction. |
| CFN97454 | Isomexoticin Isomexoticin is a natural product from Murraya exotica L. |
| CFN90153 | Sauchinone Sauchinone possesses diverse pharmacological properties, such as hepatoprotective, neuroprotective, anti-inflammatory and anti-tumor effects. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Sauchinone can be used for the prevention of functional β-cell damage, it prevents cytokine-induced NO production, iNOS expression,JAK/STAT activation,and NF-κB activation and inhibition of glucose-stimulated insulin secretion (GSIS). |
| CFN90152 | 11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase; and it can increase the Nrf2 and HO-1 expression, which provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. 11-Keto-beta-boswellic acid possesses significant anti-inflammatory, and anti-tumoral activities. |
| CFN97446 | Alismol Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. Alismol has inhibitory effect to MMP3 expression and nitric oxide produced in microglial cells. It holds great promise for use in chemopreventive and chemotherapeutic strategies. |
| CFN90148 | Sophoricoside Sophoricoside has anti-inflammatory, anti-cancer, anti-bone loss, and immunosuppressive effects. Sophoricoside is an effective regulator of lipogenesis and glucose consumption and may find utility in the treatment of obesity and type 2 diabetes. Sophoricoside exposure reduced the number of implanted embryos in a dose-dependent manner and failed the embryo implantation through altering the morphology of uterine and compromising the endometrial receptivity. |
| CFN97444 | 6-Hydroxyrubiadin 6-Hydroxyrubiadin has antioxidant activity, EC(50) is 14.7ug/ml. |
| CFN97442 | Smyrindioloside Smyrindioloside is a natural product from Smyrnopsis aucheri Karjag. |
| CFN97441 | Kelampayoside A Kelampayoside A is a natural product from Callicarpa peii. |
| CFN90139 | Sagittatoside A Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα, and sagittatoside A and icariin induces ERα phosphorylation at serine 118 residue. |
| CFN97433 | 5-Hydroxy-1,7-diphenyl-6-hepten-3-one 5-Hydroxy-1,7-diphenyl-6-hepten-3-one has antioxidant activity. |
| CFN90137 | Cinobufotalin Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells(DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its(the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B(CHB). |
| CFN90135 | Protosappanin B Protosappanin B possesses antitumor, anti-inflammation and anti-oxidation properties, it protects PC12 cells against oxygen–glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation. |
| CFN97431 | threo-Guaiacylglycerol beta-coniferyl ether Threo-Guaiacylglycerol beta-coniferyl ether displays significant inhibitory effects on NO production. |
| CFN97419 | Curculigoside Curculigoside has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. Curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Curculigoside exhibits potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts, and increases the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. |
| CFN97412 | 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption. |
| CFN97404 | 5-Epilithospermoside (-)-5-Epilithospermoside is proposed as a potential marker of botanical origin for phacelia honey. |
| CFN97285 | 2',5,6',7-Tetrahydroxyflavanone (2S)-2',5,6',7-Tetrahydroxyflavanone can inhibit the lipid peroxide formation induced by adenosine diphosphate and reduced nicotinamide adenine dinucleotide phosphate in rat liver homogenate. |
| CFN97276 | Artemisinic acid Artemisinic acid, is the immediate precursor of the semi-synthesis artemisinin, could be a cost-effective, environmentally friendly, high-quality and reliable source of artemisinin. Artemisinic acid has a variety of pharmacological activity, such as antimalarial, anti-tumor, antipyretic, antibacterial, allelopathy and anti-adipogenesis effects. Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression, it inhibits adipogenic differentiation of hAMSCs through reduced expression of C/EBP δ; it inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene. |
