Natural Products
| Catalog No. | Information |
| CFN97444 | 6-Hydroxyrubiadin 6-Hydroxyrubiadin has antioxidant activity, EC(50) is 14.7ug/ml. |
| CFN97442 | Smyrindioloside Smyrindioloside is a natural product from Smyrnopsis aucheri Karjag. |
| CFN97441 | Kelampayoside A Kelampayoside A is a natural product from Callicarpa peii. |
| CFN90139 | Sagittatoside A Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα, and sagittatoside A and icariin induces ERα phosphorylation at serine 118 residue. |
| CFN97433 | 5-Hydroxy-1,7-diphenyl-6-hepten-3-one 5-Hydroxy-1,7-diphenyl-6-hepten-3-one has antioxidant activity. |
| CFN90137 | Cinobufotalin Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells(DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its(the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B(CHB). |
| CFN90135 | Protosappanin B Protosappanin B possesses antitumor, anti-inflammation and anti-oxidation properties, it protects PC12 cells against oxygen–glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation. |
| CFN97431 | threo-Guaiacylglycerol beta-coniferyl ether Threo-Guaiacylglycerol beta-coniferyl ether displays significant inhibitory effects on NO production. |
| CFN97419 | Curculigoside Curculigoside has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. Curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Curculigoside exhibits potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts, and increases the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character. |
| CFN97412 | 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption. |
| CFN97404 | 5-Epilithospermoside (-)-5-Epilithospermoside is proposed as a potential marker of botanical origin for phacelia honey. |
| CFN97285 | 2',5,6',7-Tetrahydroxyflavanone (2S)-2',5,6',7-Tetrahydroxyflavanone can inhibit the lipid peroxide formation induced by adenosine diphosphate and reduced nicotinamide adenine dinucleotide phosphate in rat liver homogenate. |
| CFN97276 | Artemisinic acid Artemisinic acid, is the immediate precursor of the semi-synthesis artemisinin, could be a cost-effective, environmentally friendly, high-quality and reliable source of artemisinin. Artemisinic acid has a variety of pharmacological activity, such as antimalarial, anti-tumor, antipyretic, antibacterial, allelopathy and anti-adipogenesis effects. Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression, it inhibits adipogenic differentiation of hAMSCs through reduced expression of C/EBP δ; it inhibits melanogenesis through downregulation of C/EBP α-dependent expression of HMG-CoA reductase gene. |
| CFN97268 | N-trans-Feruloyl-3-methoxytyramine N-trans-Feruloyl-3-methoxytyramine shows significantly DPPH radical scavenging activities. |
| CFN97254 | Garcinone C Garcinone C is a potent inhibitor of AChE. It is an active compound against both of pathogenic (MIC =100 μg/ml) and non-pathogenic leptospira (MIC = 200 μg/ml). Garcinone C exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro. |
| CFN97237 | Cedrusin Cedrusin shows a cytotoxic effect on A375 and HeLa cells. |
| CFN97233 | Obacunone Obacunone is a novel activator of Nrf2, which exhibits anti-cancer, anti-inflammatory, antivirulence, insecticidal, anti-proliferative and anti-aromatase activities. Obacunone stimulates muscle hypertrophy and prevents obesity and hyperglycemia, and that these beneficial effects are likely to be mediated through the activation of TGR5 and inhibition of PPARγ transcriptional activity. Obacunone significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM, and it also inhibits the p38 MAPK signaling pathway. |
| CFN97220 | Acanthoside B Acanthoside has inhibitory effects on the allergic inflammation. |
| CFN97181 | 8-O-Acetylharpagide 8-O-Acetylharpagide has anti-inflammatory, vasoconstrictor, antibacteria and antiviral activities, it also has a biological activity on isolated smooth muscle preparations from guinea pig. 8-O-Acetylharpagide presents the obvious inhibition on Epstein-Barr virus(EBV) infection, it not only apparently inhibits EBV-VCA,but also alleviates the hyperfunction and effusion of capillary permeability at the early inflammation. |
| CFN97180 | Pinoresinol 4-O-beta-D-glucopyranoside (+)-Pinoresinol 4-O-beta-D-glucopyranoside revealed that the presence of a vanilloyl group in the sugar moiety of (+)-pinoresinol 4-O-[6″-O-vanilloyl]-β-D-glucopyranoside is crucial for its anti-influenza virus activity. |
| CFN97166 | Isowighteone Isowighteone, a compound that is not naturally produced in this species, accumulated by medicago truncatula hairy roots expressing LaPT1, indicates a strategy for metabolic engineering of novel antimicrobial compounds in legumes; it may have antimicrobial activity against fungal pathogens of plants. |
| CFN97160 | Trifolirhizin Trifolirhizin possesses potential anti-inflammatory and anti-cancer activities, it inhibits acetylcholine mediated airway smooth muscle (ASM) contraction or directly relaxes pre-contracted ASM independent of β 2 -adrenoceptors. Trifolirhizin may be a a candidate as skin-whitening agents, it exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis. |
| CFN97142 | Psoralen Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen has immunomodulatory properties on Th2 response in vitro, it can remit the degeneration of lumbar intervertebral disc induced by IL-1β to some extent, and affect the related factors of IL-1β signaling pathway. Psoralen may be feasible for reversing the multidrug resistance by inhibiting ABCB1 gene and protein expression. Psoralen ultraviolet A is an effective treatment for psoriasis. |
| CFN97135 | N-trans-Feruloyltyramine N-trans-Feruloyltyramine(NTF) is a platelet aggregation inhibitor, which has hepatoprotective, and antioxidative effects, NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets;NTF inhibits melanogenesis in a dose-dependent manner. |
| CFN97133 | Dihydroguaiaretic acid Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. It shows an inhibitory effect against the complex formation of the fos-jun dimer and the DNA consensus sequence with an IC50 value of 0.21 micromol, suppresses leukemia, lung cancer and colon cancer in an in vitro bioassay. Meso-dihydroguaiaretic acid inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) (IC50 9.8 μM). |
| CFN97107 | Shanzhiside methylester Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling. |
| CFN97106 | Mussaenoside Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB. Mussaenoside can inhibit the release of pro-inflammatory cytokines induced by LPS, the production of nitric oxide (NO) and prostaglandin E2, and the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. |
| CFN97102 | Longistylin C Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7. |
| CFN97101 | Torachrysone 8-O-glucoside Torachryson-8-O-glucoside shows alpha-glucosidase inhibitory activities, it may be used for the management of type 2 diabetes. |
| CFN97089 | Wogonin Wogonin is an inhibitor of CDK9, which has anti-inflammatory and anti-tumor activities, it could be developed into an efficient natural sensitizer for resistant human myelogenous leukemia. It has a wide spectrum of targets including PGE2, NO, Nrf2, Src, MEK1/2, ERK1/2, NFκB,MLCK, MLC. |
| CFN97086 | Morusinol Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or stroke via the modulation of platelet activation. |
| CFN97085 | Mulberrin Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM; it also as HIV-1 reverse transcriptase inhibitor. Mulberrin has significantly reduced role on blood sugar of type II diabetes model of rats. |
| CFN97083 | Morusin Morusin exhibits antinociceptive, analgesic, anticonvulsant, antibacterial, and antitumor activities. Morusin can inhibit NF-κB and STAT3 activity, activate caspases activity, and restorate GABA level. |
| CFN90134 | Saponarin Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. Saponarin exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling.Saponarin is characterized as α-glucosidase inhibitor present in Tinospora cordifolia, it also has hypoglycemic activity in the range of 20-80 mg/kg compared to 100-200 mg/kg for acarbose as reported.Saponarin also exerts slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR). |
| CFN90133 | Isosaponarin Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production. |
| CFN90131 | Vaccarin Vaccarin exhibits extensive biological activities including vascular endothelial cell protective effects, it can significantly promote neovascularization by enhancing protein expression of p-Akt , p‑Erk, and CD31, and selectively protect vascular endothelium from dysfunction induced by H2O2. |
| CFN97068 | alpha-Viniferin Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities. Alpha-Viniferin inhibits AChE activity is specific, reversible and noncompetitive, in a dose-dependent manner, and the IC50 values of alpha-Viniferin were 2.0 microM. Alpha-Viniferin exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 microM, it down-regulates STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. |
| CFN90127 | Dihydrochelerythrine Dihydrochelerythrine has antifungal activity against pathogenic plant fungi; it shows antiparasitic efficacy against Ichthyophthirius multifiliis in richadsin, it has potential application in the therapy of serious infection caused by I. multifiliis. Dihydrochelerythrine affects cell cycle distribution, activates mitochondrial apoptotic pathway, and induces apoptosis and necrosis in HL-60 cells. |
| CFN90126 | Hosenkoside G Hosenkoside G is a natural product from Impatiens balsamina L. |
| CFN90122 | Gomisin D Gomisin D is a natural product from Schizandra chinensis. |
| CFN97050 | alpha-Mangostin Alpha-Mangostin has neuroprotective, anti-cancer, antifungal, neuroprotective, renoprotective, antioxidant and anti-inflammatory activities. Alpha-Mangostin exhibits peripheral and central antinociception through modulation of opioid and vanilloid receptors, the glutamatergic system, and the larginine/NO/cGMP/PKC/K(+)-ATP pathways; it suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells. Alpha-Mangostin is also a novel competitive histamine H1 receptor antagonist in smooth muscle cells. |
| CFN97049 | Isoacteoside Isoacteoside exhibits significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM; it has neuroprotective, antioxidant, and anti-inflammatory effects. Isoacteoside can stimulate the increase of α7 and α3 proteins in the cultured cells, attenuate the decreased expression of α3 and α7 nAChR subunit proteins and cell viability on SH-SY5Y cells induced by Aβ; it can regulate caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways. |
| CFN97048 | Acteoside Acteoside is a lipase inhibitor, has neuroprotective, anti-obesity,anti-inflammatory, antioxidant, anticancer, cytotoxic,antihypertensive, analgesic, and antimetastatic activities. Acteoside can promote nerve growth factor and tropomycin receptor kinase A expression, inhibit arachidonic acid release and prostaglandin E2 production induced by 0.5 microM melittin. Acteoside can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen‑activated protein kinase signaling pathways. |
| CFN97045 | Grandifloroside Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory agents and therapeutic agent for benign prostatic hypertrophy (BPH). |
| CFN97038 | Phlorizin Phlorizin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. Phlorizin may be a novel therapeutic approach for the treatment of diabetic nephrolog, it protects mice from diabetic nephrology. Phlorizin prevents ventricular tachyarrhythmia through the improvement of impulse conduction slowing during ischemia. |
| CFN97035 | Norbraylin Norbraylin is a natural product from Toddalia asiatica. |
| CFN97026 | Chrysosplenetin Chrysosplenetin is a metabolic inhibitor of artemisinin, it has strong activity in vitro against EV71 with low cytotoxicity. Co-administration of artemisinin(ART) with chrysosplenetin(CHR) in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART. |
| CFN97013 | Oblongine Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by β-adrenergic receptor stimulation. |
| CFN97005 | Sissotrin Sissotrin can impair glucose tolerance. |
| CFN98996 | Secoxyloganin Secoxyloganin possesses hepato- protective, cytotoxic, and antibacterial activities, it has the perfect protective effect on PRRSV infected cell and with the minimum protection concentration of 6. 25 Âμg/mL. |
