Natural Products
| Catalog No. | Information |
| CFN97432 | 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid inhibits the MRCKα kinase with Kd50 of 3.0 uM, it also inhibits the MRCKβ kinase with Kd50 of 3.2 uM; the role of Kinases in cancer onset and progression has made kinases a target for the control of some cancers, suggests that it may possess anticancer activity. |
| CFN90135 | Protosappanin B Protosappanin B possesses antitumor, anti-inflammation and anti-oxidation properties, it protects PC12 cells against oxygen–glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation. |
| CFN90136 | Demethylzeylasteral Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7, and the inhibition kinetic parameters (Ki) are calculated to be 0.6 uM and 17.3 uM for UGT1A6 and UGT2B7, respectively. Demethylzeylasteral has antimicrobial, strong immunosuppressive, and antifertility activities; it concentration-dependently and in a partially reversible manner can inhibit the Ca(2+) current in spermatogenic cells with an IC(50) of 8.8 microg/ml, and it also can inhibit significantly the sperm acrosome reaction initiated by progesterone. |
| CFN90137 | Cinobufotalin Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells(DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its(the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B(CHB). |
| CFN97433 | 5-Hydroxy-1,7-diphenyl-6-hepten-3-one 5-Hydroxy-1,7-diphenyl-6-hepten-3-one has antioxidant activity. |
| CFN97434 | 5-Methoxystrictamine Standard reference |
| CFN97435 | Dihydrotanshinone I Dihydrotanshinone I is a potent inhibitor of the HuR:RNA interaction, it exhibits strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation, and UDP-glucuronosyltransferase (UGT) 1A7. Dihydrotanshinone I has antibacterial, anti-cancer, anti-angiogenic, and cytotoxic activities, it induces caspase and ROS dependent apoptosis and autophagy. |
| CFN97436 | Daphnilongeranin A Daphnilongeranin A is a natural product from Cimicifuga foetida L. |
| CFN90138 | Ikarisoside F Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level. |
| CFN90139 | Sagittatoside A Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα, and sagittatoside A and icariin induces ERα phosphorylation at serine 118 residue. |
| CFN90140 | Coptisine sulfate Coptisine sulfate can competitively inhibit CYP2D6(*)1 and CYP2D6(*)10, its Ki values for CYP2D6(*)1 and CYP2D6(*)10 are very close, suggesting that genotype-dependent herb-drug inhibition is similar between the two variants. |
| CFN90141 | Glycerine trioleate Glycerine trioleate could as a marker in the radioisotope method. |
| CFN90142 | Vinorelbine Tartrate Vinorelbine Tartrate is an antitumor drug. |
| CFN90143 | (R)-(+)-Corypalmine (-)-Corypalmine has inhibition activity on spore germination of plant pathogenic and saprophytic fungi. |
| CFN90144 | (-)-Asarinin Asarinin, a mammalian lignan precursor, has immunosuppression activity in vitro. Asarinin can decrease peripheral blood concentration of interleukin (IL)-12 and inhibit the expression of Toll-like receptor 4 (TLR4) and chemokine (C-X-C motif) receptor 3 (CXCR3), which means asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival. |
| CFN90145 | Diacerein Diacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.The feasibility of targeted delivery of Diacerein to articular tissue using soluble polysaccharide chondroitin sulfate as the targeting vector, this approach has the potential to significantly increase anti-arthritic drug concentration in joints without leading to systemic toxicity. |
| CFN97437 | Viteralone Reference standards. |
| CFN97438 | 11(13)-Dehydroivaxillin 11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy. |
| CFN97439 | Dihydroajugapitin Standard reference |
| CFN97440 | ent-14,15-Dinor-13-oxolabda-8(17),11-dien-18-oic acid Reference standards. |
| CFN97441 | Kelampayoside A Kelampayoside A is a natural product from Callicarpa peii. |
| CFN97442 | Smyrindioloside Smyrindioloside is a natural product from Smyrnopsis aucheri Karjag. |
| CFN97443 | Pyrogallol Pyrogallol is a polyphenol compound, which has anti-fungal, anti-psoriatic, anti-inflammatory, and antiproliferative effects . Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions; it is both a sensitizer, a carcinogenic, and an irritant in female BALB/c mice. |
| CFN97444 | 6-Hydroxyrubiadin 6-Hydroxyrubiadin has antioxidant activity, EC(50) is 14.7ug/ml. |
| CFN90146 | Vinblastine Sulfate Vinblastine Sulfate has anticancer activity, using FA-BSANPs as a drug carrier system could be effective in targeting Vinblastine Sulfate-sensitive tumors in the future. Vinblastine Sulfate could offer protection to the normal tissues against gamma-radiation-induced DNA strand breaks. The changes induced on the rabbit OM by Vinblastine sulphate are transient and that regenerative recovery leads to the restoration of the normal structure of the mucosa. |
| CFN90147 | Yohimbine Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. Yohimbine may augment extinction learning without significant side effects, and as a therapeutic augmentation strategy for exposure therapy in social anxiety disorder. Yohimbine can be used as antagonistic agents against medetomidine-induced diuresis in healthy cats; it inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells. |
| CFN90148 | Sophoricoside Sophoricoside has anti-inflammatory, anti-cancer, anti-bone loss, and immunosuppressive effects. Sophoricoside is an effective regulator of lipogenesis and glucose consumption and may find utility in the treatment of obesity and type 2 diabetes. Sophoricoside exposure reduced the number of implanted embryos in a dose-dependent manner and failed the embryo implantation through altering the morphology of uterine and compromising the endometrial receptivity. |
| CFN97445 | 6beta-Hydroxyipolamiide Standard reference |
| CFN97446 | Alismol Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. Alismol acts primarily on nerve terminals and inhibits their responses to electrical stimulation by interfering with NAd release. Alismol has inhibitory effect to MMP3 expression and nitric oxide produced in microglial cells. It holds great promise for use in chemopreventive and chemotherapeutic strategies. |
| CFN97447 | Daphniyunnine A Daphniyunnine A is a natural product from Daphniphyllum macropodum Miq. |
| CFN97448 | Daphniyunnine B Daphniyunnine B is a natural product from Daphniphyllum macropodum Miq. |
| CFN90149 | Desmethoxy yangonin Desmethoxyyangonin is a reversible inhibitor of MAO-B, it may have important therapeutic value for treatment of neurodegenerative disorders and Parkinson's Disease. Desmethoxy yangonin protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. |
| CFN90150 | Kaempferol-7-O-D-glucopyranoside Kaempferol 7-O-beta-d-glucopyranoside, a novel supercoolant could be used to sub-zero non-freezing rat heart preservation. |
| CFN90151 | Bufarenogin ψ-Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.ψ-Bufarenogin exhibits potent therapeutic effect in xenografted human hepatoma without notable side effects,at least partially,via inhibiting receptor tyrosine kinases-regulated signaling. |
| CFN97449 | 3,5,9-Trihydroxyergosta-7,22-dien-6-one 3β,5α,9α-Trihydroxy-ergosta-7,22-dien-6-one in the presence of NGF (20 ng/mL) exerts a significant increase in neurite-bearing cells. |
| CFN97450 | Methyl syringate Methyl syringate is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression. Methyl syringate has a unique inhibitory activity toward aflatoxin production. Methyl syringate could be effective to suppress hypoxia-induced inflammation, it inhibits the hypoxic induction of COX-2 expression and cell invasion through TRPA1 activation. |
| CFN97451 | Murraxocin Murraxocin is an insecticidal coumarin. |
| CFN97452 | Kongensin A Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications. |
| CFN90152 | 11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase; and it can increase the Nrf2 and HO-1 expression, which provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. 11-Keto-beta-boswellic acid possesses significant anti-inflammatory, and anti-tumoral activities. |
| CFN90153 | Sauchinone Sauchinone possesses diverse pharmacological properties, such as hepatoprotective, neuroprotective, anti-inflammatory and anti-tumor effects. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Sauchinone can be used for the prevention of functional β-cell damage, it prevents cytokine-induced NO production, iNOS expression,JAK/STAT activation,and NF-κB activation and inhibition of glucose-stimulated insulin secretion (GSIS). |
| CFN90154 | Cucurbitacin E Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions, it also exhibits immunosuppressive effect by attenuating critical cytokine expression through down-regulating the NF-κB signaling pathway. |
| CFN97453 | Minumicrolin Minumicrolin is a plant growth inhibitor against the 2nd leaf sheath elongation of rice seedlings. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100, it might be valuable anti-tumor-promoting agents. Minumicrolin shows mild butyrylcholinesterase inhibition activity. |
| CFN97454 | Isomexoticin Isomexoticin is a natural product from Murraya exotica L. |
| CFN97455 | Cerebroside B Cerebroside B1b has antiulcerogenic activity. |
| CFN97456 | 11,12-De(methylenedioxy)danuphylline Standard reference |
| CFN90155 | Liquidambaric lactone Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity. |
| CFN90156 | Solasonine Solasonine displays leishmanicidal activity against promastigote forms of L. amazonensis. |
| CFN97457 | erythro-Guaiacylglycerol beta-coniferyl ether erythro-Guaiacylglycerol beta-coniferyl ether displays significant inhibitory effects on NO production. |
| CFN97458 | 24,25-Epoxytirucall-7-en-3,23-dione Reference standards. |
| CFN97459 | Betulin caffeate Betulin-3β-caffeate shows moderate antioxidant activity with IC50 value 108.0 ug/ml. |
