Natural Products
| Catalog No. | Information |
| CFN98602 | Isohemiphloin Standard reference |
| CFN98603 | Naringenin triacetate Naringenin triacetate exhibits a better binding affinity with multiple crystal structures of first bromodomain BRD4 (BRD4 BD1) when compared with the known inhibitors. |
| CFN98604 | Murrangatin Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein–Barr virus early antigen (EBV–EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277). Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1β, tumor necrosis factorα, prostaglandins E2,and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2. |
| CFN98605 | Wilforgine Wilforgine exhibits insecticidal activity of some degree. |
| CFN98606 | 7,4'-Dihydroxy-3'-prenylflavan 7,4'-Dihydroxy-3'-prenylflavan has antibacterial activity. |
| CFN98549 | Methyl salicylate Methyl salicylate is a common herbivore-induced plant volatile that, when applied to crops, has the potential to enhance natural enemy abundance and pest control. Methyl salicylate has both stimulatory and inhibitory actions on TRPV1 channels, it shows analgesic effects. |
| CFN98550 | Anethole Anethole has antispasmodic, anti-inflammatory, cardiovascular, and gastroprotective effects. Anethole can act as the CXCR4 antagonist and as the PTEN activator which resulted to PI3K/AKT-mediated inhibition of the metastatic prostate cancer progressions. Anethole may have a potent inhibitory effect on PD through suppression of pro-inflammatory molecules, it could be a novel therapeutic strategy for Periodontitis. Anethole blocks neuronal excitability,and induces the blockade of neuromuscular transmission. trans-Anethole has insecticidal activity to adult fruit flies of Ceratitis capitata, Bactrocera dorsalis, and Bactrocera cucurbitae. |
| CFN98551 | Citric acid Citric acid is a natural preservative and food tartness enhancer, it is also an Al-chelating substance and a natural antioxidant. Citric acid (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. Citric acid has phytoremediation of heavy metal contaminated soil; citric acid can decrease the adsorption of both lead and cadmium. Dietary citric acid can effectively improve phytate P utilization in chicks. |
| CFN98552 | Folic acid Folic acid supplementation improves arterial endothelial function in adults with relative hyperhomocystinemia, with potentially beneficial effects on the atherosclerotic process. Both local perfusion of 5-MTHF and supplementation with folic acid increase vasodilatation in ageing individuals through NO-dependent mechanisms. The combined use of enalapril and Folic acid significantly reduced the risk of first stroke, folic acid deficiency and homocysteine impaired DNA repair in hippocampal neurons and sensitized them to amyloid toxicity. |
| CFN98607 | 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)propane Reference standards. |
| CFN98608 | 8-Acetonyldihydrosanguinarine |
| CFN98609 | Dehydroabietinol Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). |
| CFN98610 | Totaradiol Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line. |
| CFN98611 | Phaseollidin Phaseollidin, a phytoalexin from Phaseolus vulgaris, has antimicrobial activity. It also has anti-anxiety properties. |
| CFN98612 | Cimifugin Cimifugin evidently inhibits FITC-induced type 2 allergic contact dermatitis,and its mechanism might related to regulating the balance of Th1 /Th2 by inhibiting type 2 cytokines. Cimifugin displayed low to moderate inhibition towards AChE and BChE (3.12 and 21.63%, respectively) at 200 ug/mL. |
| CFN98613 | alpha-Epoxydihydroartemisinic acid Reference standards. |
| CFN98614 | Pterolactam Reference standards. |
| CFN98615 | beta-Amyrenonol Standard reference |
| CFN98616 | Naringenin trimethyl ether Naringenin trimethyl ether shows significant molluscicidal activity with a median lethal concentration (LC(50)) of 3.9 μg/mL. |
| CFN98553 | Salvianolic acid C Salvianolic acid C has antioxidant effect, it exhibits potent XOD inhibitory activity with an IC(50) of 9.07 μM. Salvianolic acid C enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects. |
| CFN98554 | Ophiopogonin A Reference standards. |
| CFN98555 | Ophiopogonin B Ophiopogonin B is often used in Chinese traditional medicine to treat pulmonary disease, it is a prospective inhibitor of PI3K/Akt and may be used as an alternative compound to treat NSCLC. It may be considered a potential inhibitor of gastric cancer progression, and may be used as an alternative compound for its treatment. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy , has inhibitory effect on adhesion, invasion and migration of A549 cells in vitro. |
| CFN98556 | Ophiopogonin C Ophiopogonin C' pharmacological activities may be related to the substances in nucleus mainly. |
| CFN98557 | Scutellarein Scutellarein has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities, it can improve neuronal injury, has better protective effect in rat cerebral ischemia. Scutellarein may serve as a SARS-CoV chemical inhibitor, it also exerts strong inhibition towards the tested UDP-glucuronosyltransferase isoforms. |
| CFN98558 | Beta-Hederin Beta-Hederin has antileishmanial activity; it has apoptotic effect on breast cancer cells, it could be a promising candidate for chemotherapy of breast cancer. |
| CFN98559 | Epoxylathyrol Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells. |
| CFN98560 | Atractyloside A Atractyloside is a toxic compound from wedelia glauca. It acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions, the effect is due to inhibition of the ADP utilizing process in the coupling system. Atractyloside, has been proposed for the antibiotic oligomycin, is an inhibitor of the energy-transfer reactions in animal mitochondria; it inhibits the phosphate uptake and the respiratory stimulation induced by P1-acceptor, but it does not interfere with the so-called resting respiration. |
| CFN98617 | 3,4,4',7-Tetrahydroxyflavan Standard reference |
| CFN98618 | Seneciphylline N-oxide Seneciphylline N-oxide and senecionine N-oxide are probably tumorigenic due to their potential conversion into seneciphylline and senecionine via metabolic reduction in the body. |
| CFN98619 | erythro-Guaiacylglycerol Reference standards. |
| CFN98620 | Isovitexin Isovitexin, a food phytochemical contained in dietary rice products, it exhibits in vivo α-glucosidase inhibition, it possesses antihyperglycemic, neuroprotective, anti-inflammatory and anti-oxidant activities. Isovitexin inhibited xanthine oxidase with an IC50 value of 15.2 microM, it may protect cells from oxidative stress. It inhibited JNK, MAPK and NF-κB and activated HO-1/Nrf2 pathways. |
| CFN98621 | 2'-O-Methylperlatolic acid 2'-O-Methylperlatolic acid and confluentic acid are monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba. |
| CFN98622 | Gelsevirine Gelsevirine has anxiolytic activity, may be via the agonist action of glycine receptor in the brain. Gelsevirine can significantly inhibit the proliferation of human carcinoma cell line SW480 and MGC80-3 in a dose-dependent manner, the 50% inhibiting concentration(IC50)of gelsevirine on SW480 cells and MGC80-3 cells are 1.41±0.06 mM and 1.22±0.11 mM respectively. |
| CFN98623 | Nuezhenide Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage. It significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity. |
| CFN98624 | Wilsonine Standard reference |
| CFN98625 | 3-Epiwilsonine Standard reference |
| CFN98626 | Buxbodine B Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM. |
| CFN98561 | Atractyloside potassium salt Atractyloside potassium salt inhibits oxidative phosphorylation by blocking the transfer of adenosine nucleotides through the mitochondrial membrane. |
| CFN98562 | Roburic acid Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2. |
| CFN98563 | Notopterol Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities, it shows significant antiproliferative activity against the HepG-2, MCF-7 and C6 cancer cell lines. |
| CFN98564 | Epiberberine Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean); it also exhibits predominant cholinesterases (ChEs) inhibitory effects with IC(50) values ranging between 0.44-1.07 microM for AChE and 3.32-6.84 microM for BChE. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte differentiation. Epiberberine also ha anti-alzheimer and antioxidant activities. |
| CFN98565 | Luteolin-7-O-glucoside Luteolin-7-O-glucoside has cardioprotective, anti-asthmatic, anticancer, anti-inflammatory, and antioxidative activities, it can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.Luteolin-7-O-glucoside modulated the Nrf2/MAPK/ PTEN/Akt /ERK/AP-1/PI3K-Akt signaling pathways, it suppressed the expression of β-catenin. |
| CFN98566 | Cordycepin Cordycepin possesses immunological stimulating,anti-hyperglycemia, anti-cancer, neuroprotective, antifungal, antibacterial, anti-inflammatory, anti-virus and anti-infection activities. Cordycepin has inhibitory effects on osteoclast differentiation in vitro and that it suppresses inflammatory bone loss in vivo. Cordycepin inhibited the production of NO production by down-regulation of iNOS and COX-2 gene expression via the suppression of NF-κB activation, Akt and p38 phosphorylation, suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b. |
| CFN98567 | Luteosporin Luteosporin and xanthomegnin are pigments, they are suspected to be genotoxic carcinogens. Luteosporin inhibits porcine pancreatic phospholipase A2 (PLA2) with Ki values of 12.8 microM. |
| CFN98568 | Luteollin 5-glucoside Luteolin 5-O-β-glucopyranoside has antioxidant activity, it can inhibit lipid peroxidation, and has DPPH radical-scavenging activity. |
| CFN98627 | Buxbodine D Standard reference |
| CFN98628 | Kamebanin Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells. |
| CFN98629 | Daphmacropodine Reference standards. |
| CFN98630 | Epitulipinolide diepoxide Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells, it possesses cytotoxic activity against KB cells. |
| CFN98631 | Methyllinderone Methyllinderone is a human chymase inhibitor, it has antioxidant property, it also shows moderate to weak antifungal activities against various pathogenic fungi. Methyllinderone can inhibit farnesyl protein transferase with IC50 value of 55.3+/-4.1microM and selectively inhibit the growth of H-ras-transformed rat-2 cell lines with a GI50 value of 0.3 microM. Methyllinderone shows significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED(50) values of 2.2, 2.5, 8.3 mug/ml, respectively. |
