Natural Products
| Catalog No. | Information |
| CFN98971 | Isofuranodiene Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apoptosis in cancer cells; it can induce apoptosis in colon cancer cells in a time and concentration-dependent manner suggesting a potential role as models for the development of chemopreventive agents. Isofuranodiene at concentrations of 25 and 12.5 lM alone, or in combination with 50 nM nerve growth factor (NGF) , shows a marked stimulation of neuritogenesis,which appears to be a promising neurotrophic and neuroprotective agent. |
| CFN98972 | Cycloartane-3,24,25-triol Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. |
| CFN98973 | (24S)-Cycloartane-3,24,25-triol 24,25-acetonide Reference standards. |
| CFN98974 | (2,4-Dihydroxyphenyl)acetonitrile (2,4-Dihydroxyphenyl)acetonitrile is a natural product from Diploclisia glaucescens. |
| CFN98975 | Norcepharadione B Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. Norcepharadione B shows significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation. |
| CFN98976 | Baccatin IV Baccatin IV is a natural product from Taxus chinensis. |
| CFN00181 | Brugine Brugine is a natural product from Bruguiera sexangula. |
| CFN00182 | Chalcostrobamine Reference standards. |
| CFN00183 | Cocaine Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America, it produces short-term euphoria. Cocaine has a small number of accepted medical uses such as numbing and decreasing bleeding during nasal surgery, it constricts blood vessels, dilates pupils, and increases body temperature, heart rate, and blood pressure. Cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces Cocaine seeking.Cocaine also can cause headaches and gastrointestinal complications such as abdominal pain and nausea. Because cocaine tends to decrease appetite, chronic users can become malnourished as well. |
| CFN00184 | Pseudococaine Pseudococaine produces high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression, it is more potent than cocaine in producing convulsions in the same monkeys. |
| CFN00185 | Consiculine Consiculine is a natural product from Convolvulus siculus. |
| CFN00186 | Convolvine Convolvine and its derivatives exhibit pronounced antihypoxic, immunomodulating, and anti-inflammatory activity, they exhibit cytotoxic activity, the alkaloids N-benzylconvolvine and N-chloroacetylconvolvine at concentrations of 10 ug/mL exhibit the greatest activity against HeLa and Hep cancer cell cultures. Convolvine blocks the M-receptors of the heart and intestine but raises the sensitivity of the M-receptors of the salivary gland and of the CNS,convolvine has revealed characteristics of a sedative and nootropic agent. |
| CFN00187 | Convolamine Convolamine may have antihypoxic, immunomodulating, and anti-inflammatory activity. |
| CFN00188 | Darlingine Reference standards. |
| CFN98977 | 11,15-Dihydroxy-16-kauren-19-oic acid Reference standards. |
| CFN98978 | 2-Acetylbenzoic acid 2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potencies of these agents were comparable in inhibiting prostacyclin (PGI2) synthesis. |
| CFN98979 | 4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol Reference standards. |
| CFN98980 | Ergosterol Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects, ergosterol peroxide has the potential to be developed as a therapeutic agent to prevent renal fibrosis. Ergosterol can promote pheromone signaling and plasma membrane fusion in mating yeast, the critical requirement for ergosterol in V-ATPase function may underlie the antifungal activity of azoles. |
| CFN98981 | Cosmosiin Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. |
| CFN98982 | 19-Nor-4-hydroxyabieta-8,11,13-trien-7-one Reference standards. |
| CFN98983 | Matairesinol Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α in hypoxic HeLa cells.Matairesinol has anti-osteoporotic activity via p38/ERK-NFATc1 signaling, but not by way of anti-resorptive action. Matairesinol could markedly benefit TRAIL-based tumor therapies, including those aimed at prostate cancer. |
| CFN98984 | Aurantiamide Aurantiamide acetate has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux, it also inhibits cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively . Aurantiamide acetate has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways. |
| CFN98985 | Suberosin Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mosquito larvicidal agent. Suberosin inhibits PHA-induced PBMC proliferation, at least in part, through reduction of [Ca2+]i, ERK, NF-AT, and NF-kappaB activation, and early gene expression in PBMC including cyclins and cytokines, and arrest of cell cycle progression in the cells. |
| CFN98986 | Betulin palmitate Reference standards. |
| CFN00189 | Ecgonine Ecgonine is a promising marker of cocaine ingestion. |
| CFN00190 | Methylecgonine Methylecgonine is a kind of anaesthetic.It in urine as an indicator of cocaine use. |
| CFN00191 | Benzoylecgonine Benzoylecgonine, validated methodologies from matrices other than blood that can be obtained in the autopsy room would be useful to the forensic toxicologist in the evaluation of a specific forensic case. Benzoylecgonine causes oxidative stress, it and oxytocin increase myometrial contractility, while atosiban and ritodrine induce myometrial relaxation. |
| CFN00192 | Cinnamoylcocaine Reference standards. |
| CFN00193 | Ferrugine Reference standards. |
| CFN00194 | Ferruginine Ferruginine-type diazine analogues show moderate affinity for the central alpha4beta2 and remarkably low affinity for the alpha7* nAChR subtypes. |
| CFN00195 | Knightolamine Reference standards. |
| CFN00196 | Knightinol Reference standards. |
| CFN98987 | Dihydroresveratrol Dihydroresveratrol has antiproliferative activity against human prostate cancer PC3 cell line in vitro, it can ameliorate acute pancreatitis-associated lung injury via an inhibitory modulation of pro-inflammatory response, which is associated with a suppression of the NF-κB signaling pathway. |
| CFN98988 | N-(2-Hydroxy-4-methoxyphenyl)acetamide Reference standards. |
| CFN98989 | ent-16beta,17-Isopropylidenedioxykaurane Reference standards. |
| CFN98990 | Gomisin A Gomisin A has anti-inflammatory, antihypertensive, neuroprotective, and anti-proliferation properties, it induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. Gomisin A inhibits COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. |
| CFN98991 | Confluentin Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro. |
| CFN98992 | Adenosine Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Adenosine induces SphK1 activity in human and mouse sickle and normal erythrocytes in vitro, it can activate the neuroimmune system, alter neuronal function and neurotransmission,and contribute to symptoms of sickness and psychopathologies. Adenosine activates mast cells have been long implicated in allergic asthma and studies in rodent mast cells have assigned the A3 Adenosine receptor (A3R) a primary role in mediating Adenosine responses. |
| CFN98993 | 16-Oxoprometaphanine Reference standards. |
| CFN98994 | Meranzin hydrate Meranzin hydrate exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; it produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway.Meranzin hydrate can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors. |
| CFN98995 | Pinostilbenoside Reference standards. |
| CFN98996 | Secoxyloganin Secoxyloganin possesses hepato- protective, cytotoxic, and antibacterial activities, it has the perfect protective effect on PRRSV infected cell and with the minimum protection concentration of 6. 25 Âμg/mL. |
| CFN00197 | Acetylknightinol Reference standards. |
| CFN00198 | 6-beta-Hydroxyhyoscyamine 6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine. |
| CFN00199 | Isobellendine Isobellendine is a natural product from Bellendena montana. |
| CFN00200 | Littorine The kinetics of Littorine biosynthesis were in agreement with the role of this compound as a direct precursor of hyoscyamine biosynthesis. |
| CFN00201 | Merresectine B Reference standards. |
| CFN00202 | 1-Hydroxytropacocaine Reference standards. |
| CFN98997 | 9-Oxonerolidol Reference standards. |
| CFN98998 | Cassythicine Reference standards. |
