Natural Products
| Catalog No. | Information |
| CFN00135 | Reutericyclin Reutericyclin is a unique antimicrobial tetramic acid produced by some strains of Lactobacillus reuteri, dissipation of the membrane potential by active Reutericyclins correlated with inhibition of macromolecular synthesis in cells. Reutericyclin and nisin exhibit divergent effects on heat- and pressure-induced spore inactivation and membrane fluidity. All reutericyclins can inhibit the growth of clinical isolates of drug-resistant Staphylococcus aureus, which exemplify the prospect of developing reutericyclins as new topical antibiotics. |
| CFN00136 | Rubroside G Rubroside G may show antifungal activity against Aspergillus fumigatus and Candida albicans. |
| CFN00137 | Rubroside H Rubroside H may show antifungal activity against Aspergillus fumigatus and Candida albicans. |
| CFN00138 | Streptolydigin Streptolydigin has antibacterial activity against a number of Gram positive bacteria. It inhibits RNA polymerase by sequestering the active center in a catalytically inactive conformation. |
| CFN00139 | Tenuazonic acid Tenuazonic acid, an active component in the A. alternata toxin.Tenuazonic acid exhibits a strong inhibition in photosystem II (PSII) activity, it causes cell necrosis of host-plants by oxidative damage from chloroplast-mediated ROS eruption, and enhances the plant's resistances against rose aphids. |
| CFN00140 | Tirandalydigin Tirandalydigin is a new tetramic acid antibiotic, it has MICs in the range of 0.5 to 32 micrograms/ml against many pathogenic anaerobes, streptococci, enterococci and legionellae. |
| CFN00141 | Tirandamycin A Tirandamycin A and echinomycin A have anti-amoebic properties, they inhibit the in vitro growth of a E. histolytica laboratory strain (HM-1:IMSS) and a clinical isolate (Colombia, Col) at 30- to 60- uM concentrations. Tirandamycin A and streptolydigin possess potent antibacterial activity particularly against anaerobes, have been shown to inhibit bacterial RNA polymerase. |
| CFN00142 | Tirandamycin B Tirandamycin B is a BmAsnRS inhibitor, it is a leading anti-filarial drug . Tirandamycin B has antitumor and antibacterial activities. |
| CFN00143 | Vermisporin Vermisporin, a new antibiotic produced by fermentation of the fungus ophiobolus vermisporis. Vermisporin has antimicrobial activity, which MICs for enterobacteriaceae, pseudomonas aeruginosa and haemophilus influenzae exceeds 64 micrograms/ml; which MBCs is 16- to 32-fold above the MICs. |
| CFN00144 | Xanthobaccin A Xanthobaccin A, an antifungal compound, plays a key role in suppression of sugar beet damping-off disease. |
| CFN00145 | Zopfiellamide A Zopfiellamide A and Zopfiellamide B are antimicrobial metabolites. |
| CFN98917 | Pinobanksin Pinobanksin and some of its ester derivatives from Sonoran propolis have apoptotic induction in a B-cell lymphoma cell line. Pinobanksin possesses considerable antimutagenic properties against ofloxacin-induced bleaching of E. gracilis. Pinobanksin inhibits peroxidation of low density lipoprotein and it has electron donor properties reducing alpha-tocopherol radicals. |
| CFN98918 | Galangin Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. Galangin has anti-proliferation, anti-metastatic, anti-inflammatory, vasorelaxant, antiviral, anti-allergic inflammatory,anti-obesity effects; it may be a potential candidate for the treatment of vitiligo. Galangin can inhibit Topo I activity and reduce the unwinding rate of single stranded DNNA in tumor cells, which plays an important role in induction of A549 and H46 cell apoptosis. Galangin shows an inhibitory effect on acetylcholinesterase (AChE) activity with the IC(50) of 120 microM; it also inhibits ERK, NF-κB-p65 and proinflammatory gene expression. |
| CFN98919 | Gyrophoric acid Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5 J/cm(2) UVB in a dose-dependent manner, suggest that vulpinic and gyrophoric acids can be promising cosmetic ingredients to photo-protect human skin cells. Gyrophoric acid also has anti-proliferative/cytotoxic effect. |
| CFN98920 | 2-Oxopomolic acid 2-Oxopomolic acid shows cytotoxic activity, it shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin. 2-Oxopomolic acid shows radical-scavenging activities similar to that of the reference antioxidant alpha-tocopherol (vitamin E). |
| CFN98921 | beta-Yohimbine Beta-Yohimbine has approximately twice as toxic as yohimbine and corynanthine about one fifth as toxic. Beta-yohimbine has alpha-1 and alpha-2 adrenoceptor blocking activities, it has cardiovascular effects. Beta-Yohimbine has anti-plasmodial and anti-malarial activity. |
| CFN98922 | Dammar-20(21)-en-3,24,25-triol Reference standards. |
| CFN98923 | Andrographolide Andrographolide is an antiinflammatory, antiviral, anti-cancer , hepatoprotective, antithrombotic, hypotensive and antiatherosclerotic drug, it can cure hyperpigmentation disorders. Andrographolide protects against chemical-induced oxidative damage by up-regulating the gene transcription and activity of antioxidant enzymes in various tissues.Andrographolide has potential as a leading compound in the prevention or treatment of obesity and insulin resistance, can ameliorate lipid metabolism and improve glucose use in mice with HFD-induced obesity. |
| CFN98924 | Lupanine Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells. |
| CFN98925 | Benzamide Reference standards. |
| CFN98926 | Paeonol Paeonol has anticancer, anti-inflammatory, antioxidant and cardiovascular protective activities, it shows a novel inhibitory role on neuroinflammation, and presents a new candidate agent for the development of therapies for inflammation-related neurodegenerative diseases. Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively; it inhibits PGE₂ synthesis and COX-2 expression, and modulates Sirtuin 1, PKCδ and c-Src signaling pathway. |
| CFN00146 | Calystegine N1 Calystegin N~ is a weaker inhibitor of glycosidases. |
| CFN00147 | 6-Angeloyloxyditropan-3-yl itaconate Reference standards. |
| CFN00148 | Anisodine Anisodine is a traditional anticholinergics, it and anisodamine possess alpha 1-adrenoceptor blocking properties, they are widely used in the People's Republic of China for the management of acute circulatory shock . Anisodine can protect optic nerve of primary open angle glaucoma (POAG) through improving the visual function and blood supply of optic nerve. The combination of Anisodine and citicoline with standard steroid and mannitol therapy appears to be effective in the treatment of early optic nerve contusion. |
| CFN00149 | Apoatropine Reference standards. |
| CFN00150 | Apohyoscine Reference standards. |
| CFN00151 | Aponorhyoscine Reference standards. |
| CFN00152 | 8-Azabicyclo[3.2.1]octane-2,3-diol Reference standards. |
| CFN00153 | 2-Benzoyloxy-3-hydroxynortropane Standard reference |
| CFN00154 | Baogongteng C Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species. |
| CFN00155 | Baogongteng A Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species. Baogongteng A analogs as effective muscarinic agonists or antagonists in clinical use.Baogongteng A is a new tropane alkaloid used for treating glaucoma, synthetic baogongteng A also shows myotic activities in rabbits, but the potency is half of that of the natural product. |
| CFN00156 | 2,6-Tropanediol Reference standards. |
| CFN00157 | Erycibelline Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis. |
| CFN00158 | 8-Azabicyclo[3.2.1]octane-3,6-diol Reference standards. |
| CFN00159 | 3,6-Ditigloyloxynortropane Standard reference |
| CFN00160 | Calystegine C2 Calystegine C2, the 2-epimer of calystegine C1, exhibits an inhibitory activity against beta-glucosidase and beta-galactosidase. |
| CFN98927 | Isorhoifolin Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway. Isorhoifolin has antioxidant effects. It displays an anti-leakage effect comparable to or greater than diosmin. Isorhoifolin in Pilea microphylla (PM1) may reverse the disturbed metabolic milieu in C57BL/KsJ-db/db mice. |
| CFN98928 | Costunolide Costunolide has antipyretic, anti-inflammatory, anti-oxidant, anti-carcinogenic and anti-fungal activities, it possesses normo-glycemic and hypolipidemic activity. Costunolide inhibits RANKL-induced osteoclast differentiation by suppressing RANKL-mediated c-Fos transcriptional activity; it inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1; it also induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release, |
| CFN98929 | Isosaxalin Isosaxalin, heraclenin and heraclenol 3'-Me ether have melanin biosynthesis inhibitory activities. |
| CFN98930 | Mollugin Mollugin is a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin may be a novel therapeutic candidate for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis. Mollugin has anticancer efficacy, can modulate the HER2, HO-1, Nrf2 , and NF- κB pathways. |
| CFN98931 | Myriceric acid B Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 value of 6.8 uM, it also exhibits cytotoxic activity towards the MOLT-3 cell line with IC50 values of 3.9 uM. |
| CFN98932 | Biondinin C Reference standards. |
| CFN98933 | 1-Oxo-4-hydroxy-2-en-4-ethylcyclohexa-5,8-olide Reference standards. |
| CFN98934 | Stigmasta-4,22-dien-3-one Stigmasta-4,22-dien-3-one has antioxidant activity. |
| CFN98935 | beta-Amyrin beta-Amyrin has antiviral, hepatoprotective, antinociceptive, anti-inflammatory, it retard acute inflammation in rat model of periodontitis. Beta-Amyrin can enhance the total sleeping behavior in pentobarbital-induced sleeping model via the activation of GABAergic neurotransmitter system through GABA content in the brain.alpha- and beta-Amyrin mixture has gastro-protective activity, the mechanism involves at least in part the activation of capsaicin-sensitive primary afferent neurons; it also has sedative and anxiolytic effects, the mechanism may involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic mechanisms will probably play a role. |
| CFN98936 | Friedelin Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.Friedelin rich fraction (IND-HE) shows estrogenic activity as indicated by vaginal cornification, increase in uterine weight and rise in serum estrogen. Friedelin may be beneficial to mimic insulin action that would be useful in the treatment of diabetes type 2 patients. |
| CFN00161 | Calystegine B2 Calystegine B2 can inhibit the alpha-galactosidase and enzymes beta-glucosidase activities. |
| CFN00162 | Calystegine B3 Calystegine B3 is a highly specific inhibitor for Man2C1 among various α-mannosidases prepared from rat liver, it could thus serve as a potent tool for the development of a highly specific in vivo inhibitor for Man2C1. |
| CFN00163 | Calystegine B4 Calystegine B4 inhibits almond beta-glucosidase and pig kidney trehalase in a competitive manner, with a Ki value of 7.3 microM and 1.2 microM, respectively. |
| CFN00164 | Calystegine B1 Calystegine B1 is a noncompetitive inhibitor of rice alpha-glucosidase, with a Ki value of 0.9 +/- 0.1 microM. Calystegine B1 and Calystegine C1 are potent competitive inhibitors of the bovine, human, and rat beta-glucosidase activities, with Ki values of 150, 10, and 1.9 microM. |
