Natural Products
| Catalog No. | Information |
| CFN98876 | Ombuin Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process. Ombuin significantly and dose dependently inhibits lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. |
| CFN98877 | Myricetin Myricetin, a natural flavonoid with anti-amyloidogenic, anti-oxidant, anticancer, antidiabetic and anti-inflammatory properties, is a novel inhibitor of MEK1 activity and inhibits glucose uptake in isolated rat adipocytes . It also inhibits PI3Kγ with Kd of 0.17 μM. Myricetin exerts potent anti-photoaging activity by regulating MMP-9 expression through the suppression of Raf kinase activity. Myricetin can enhance osteogenic differentiation of hBMSCs by activating the Wnt/β-catenin signaling. |
| CFN98878 | Prunin Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase. |
| CFN98879 | Euxanthone Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C. Euxanthone-induced neurite outgrowth was actively regulated by transcription factor E2F-5 via PKC pathway, it-induced differentiation of the neuroblastoma BU-1 cells may be mediated through the differential expression of PKC-alpha, -beta, -delta, -lambda and -zeta isoforms. |
| CFN98880 | Acetylisocupressic acid Standard reference |
| CFN00076 | 2-Guanidinoethanesulfinic acid Reference standards. |
| CFN00077 | 1-Heptylamine 1-Heptylamine is a natural product from Tectona grandis. |
| CFN00078 | p-3-Methylamino propyl phenol Reference standards. |
| CFN00079 | 2-Hydroxybenzylamine 2-Hydroxybenzylamine is a novel scavenger that prevents oxidative stress-induced modification of cardiac sodium channels. |
| CFN00080 | 3-Hydroxybenzylamine Reference standards. |
| CFN00081 | 4-Hydroxybenzylamine 4-Hydroxybenzaldehyde derivatives are inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), 4-Hydroxybenzylamine also shows the competitive inhibition on GABA-T with respect to GABA. |
| CFN00082 | 3,3'-[Iminobis(methylene)]bis-2(3H)furanone Reference standards. |
| CFN00083 | Kuramerine Reference standards. |
| CFN00084 | Laccaic acid E Laccaic acids A, B and E as coloring matters in the examined preparations of lac-dye. |
| CFN00085 | Lavendustin A Lavendustin A is a potent tyrosine kinase inhibitor of the epidermal growth factor (EGF) receptor, and an angiogenesis inhibitor. Lavendustin A is also a hyperbolic mixed-type inhibitor with respect to both ATP and the peptide substrate, with a major effect on the binding affinities for both substrates. Lavendustin A at 0.1 nM-1 microM causes a concave-shaped inhibition of the insulin release stimulated by 7 mM glucose, the inhibitory effect can be overcomed by higher concentrations of glucose. Lavendustin A and hormothamnione exhibit cytotoxic effects on tumor cell lines. |
| CFN00086 | Lavendustin B Lavendustin B is an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75). |
| CFN00087 | 3-Methyl-1-butylamine Reference standards. |
| CFN00088 | Pahutoxin Pahutoxin is a natural fish-killing (ichthyotoxic) agent derived from the defensive secretions of trunkfish. It is also a haemolytic agent. |
| CFN00089 | Homopahutoxin Homopahutoxin is a haemolytic agent. |
| CFN00090 | Panamycin 607 Reference standards. |
| CFN00091 | Propylamine Propylamine is a natural product from grape. |
| CFN00092 | Sinapine Sinapine is an alkaloid from seeds of the cruciferous species which shows favorable biological activities such as antioxidant and radio-protective activities. |
| CFN00093 | Tetramethylammonium Tetramethylammonium ion has limited toxicity of dermal exposure, but fatal effects can be introduced by pre-treatment with hydroxide ion. |
| CFN00094 | Tribenzylamine Reference standards. |
| CFN98881 | Murralongin Murralongin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. |
| CFN98882 | Deoxyvasicinone Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme. |
| CFN98883 | 2,6-Dimethoxy-1,4-benzoquinone 2,6-Dimethoxy-1,4-benzoquinone exhibits strong antibacterial activities against S. pyogenes, S. mitis, and S. mutans with MIC values of 7.8, 7.8, and 15.6 ug/mL, and MBC values of 7.8, 7.8, and 31.2 ug/mL, respectively. 2,6-Dimethoxy-1,4-benzoquinone can produce genotoxic effects in patients taking dimethophrine. |
| CFN00095 | Trichosanatine Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine can alleviate oxidized low-density lipoprotein induced endothelial cells injury via inhibiting the LOX-1/p38 MAPK pathway. |
| CFN98884 | Syringic acid Syringic acid is a potential antioxidant used in traditional Chinese medicine and is an emerging nutraceutical. It has potential anti-angiogenic, anti-glycating, anti-hyperglycaemic,antimicrobial, fungitoxicity, neuroprotective, antimitogenic, chemo-sensitizing, anti-obesity, anti-inflammatory, anti-steatotic, and memory-enhancing properties. Syringic acid can ameliorate L-arginine methyl ester-induced hypertension by reducing oxidative stress, and can reduce the pancreatic damage induced by alloxan and stimulated β-cell regeneration in diabetic rats. Syringic acid can suppress hepatic fibrosis in chronic liver injury, it inhibits the activation of cultured hepatic stellate cells. |
| CFN98885 | 9,13-Epidioxy-8(14)-abieten-18-oic acid 9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine. |
| CFN98886 | Coniferin Coniferin has ATP-dependent transport activity; the extracts of the Balanophora involucrate and trans-Coniferin have anti-oxidation effects; the chromogenic coniferin analog show the exclusive presence of beta-glucosidase activity in the differentiating xylem, similar to peroxidase activity. |
| CFN98887 | Scopolin Scopolin exhibits significant and dose-related antinociceptive effects, it is a potential acetylcholinesterase (AChE) inhibitor. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, it may be a potent agent for angiogenesis related diseases.Scopolin and related coumarins has fungitoxic effect on Sclerotinia sclerotiorum, which is a way to overcome sunflower head rot. |
| CFN98888 | Euscaphic acid Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations. Euscaphic acid induces death by activation of caspase-3, dependent apoptotic pathway. Euscaphic acid and tormentic acid have inhibitory effect on high fat diet-induced obesity in the rat. Euscaphic acid also has anti-contraction effects on rat’s aortic smooth muscle. |
| CFN98889 | Coixol Coixol acts as a central muscle relaxant with an anti-convulsant effect; it can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells. Coixol interacts with the pituitary to stimulate reproduction in voles, it also has the ability to interact with FSH to stimulate follicular development and increase ovulation. |
| CFN98890 | Isogosferol Isogosferol is a minor furocoumarin of Murraya koenigii seeds. |
| CFN00096 | Trimethylamine oxide Trimethylamine oxide has a thermo-protective role in dogfish RBCs. It can stimulate both the anaerobic growth rate and the growth yield of Proteus NTHC 153 by serving as a terminal electron acceptor in an oxidative phosphorylation process. |
| CFN00097 | N,N,N-Trimethyl-2-aminoethylphosphonate Standard reference |
| CFN00098 | Trimethyl[3-(methylthio)propyl]ammonium(1+) Reference standards. |
| CFN00099 | 3-(Dimethylsulfonio)-N,N,N-trimethylpropanaminium(2+) Reference standards. |
| CFN00100 | Trimethylvinylammonium(1+) Reference standards. |
| CFN98891 | 1,3,5-Trihydroxy-4-prenylxanthone 1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction. |
| CFN98892 | 16-Kaurene-2,6,15-triol Reference standards. |
| CFN98893 | Creticoside C Reference standards. |
| CFN98894 | Apigenin 7-O-methylglucuronide Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, may potentially be used in osteogenesis imperfecta (OI) type I pharmacotherapy in patients with normal GAG content. Apigenin 7-O-methylglucuronide which normalized collagen synthesis in OI cells may exert their effects through beta1-integrin-mediated signaling. |
| CFN98895 | 1-Hydroxyrutaecarpine 1-Hydroxyrutaecarpine exhibits cytotoxicities (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro. It exhibits antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 micrograms/ml.1-Hydroxyrutaecarpine displays moderate inhibitory activity on those enzymes(Cathepsins B, L and K) at the concentration of 125 ug/ml. |
| CFN98896 | Lyclaninol Standard reference |
| CFN00101 | Aburatubolactam A Aburatubolactam A is an inhibitor of superoxide anion generation. It has demonstrated cytotoxic activity against P388 murine leukemia cell lines (IC50 = 26 ug/mL) and inhibits TPA-induced superoxide anion generation by human neutrophils; enhanced levels of superoxide anion is thought to be closely related to inflammation, cancer, and aging. |
| CFN00102 | Aflastatin A Aflastatin A exhibits antimicrobial activity against some bacteria, yeasts and fungi, it is a specific inhibitor of aflatoxin production by Aspergillus parasiticus, inhibits a very early step in aflatoxin biosynthesis prior to the transcription of aflR and can influence glucose metabolism in the fungus. Aflastatin A has antitumor activity. Aflastatin A inhibits an early step in melanin production, which suppresses the expression of PKS1. |
| CFN00103 | Altamycin A Altamycin A is a kind of antibiotic. |
| CFN00104 | Amycomycin Amycomycin is active against gram-positive bacteria, it is useful as an antibiotic. |
