Natural Products
| Catalog No. | Information |
| CFN98780 | Robinetin Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency. Robinetin also has anti-mutagenesis and anti-promotion effects, diminishes ornithine decarboxylase activity induction at 6 h after 12-O-tetradecanoyl phorbol-13-acetate. Robinetin leads to the occurrence of positive induced circular dichroism (ICD) bands in the near ultra-violet (UV) region. |
| CFN98781 | Epicatechin (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has antinociceptive, insulin mimic actions and improves heart health; it has the potential to increase CREB-regulated gene expression and increase GluR2 levels and thus modulate neurotransmission, plasticity and synaptogenesis. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM; it inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. |
| CFN98782 | Kaempferide Kaempferide has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.it can protect DNA from radiation induced lesions resulting from radiation exposures under in vitro and ex vivo conditions. |
| CFN98783 | Baicalein Baicalein has neuroprotective, anticancer, antioxidant and free radical scavenging effects, it inhibits mTORC1 pathway and PI3K kinase activity. Baicalein is mainly due to autophagic cell death through activation of the AMPK/ULK1 pathway and inhibition of mTOR/Raptor complex 1 expression; it can induce cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. |
| CFN98784 | Luteolin Luteolin is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin has anti-oxidant, anti-inflammation, anti-allergy anti-myocardial ischemia-reperfusion injury, and anticancer, has been used in Chinese traditional medicine for treating various diseases such as hypertension, inflammatory disorders, and cancer. Luteolin inhibits NF-κB, and inhibits interleukin (IL)-1β function induction of the inflammation biomarker cyclooxygenase (COX)-2. |
| CFN98785 | Chrysoeriol Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects; it can potentially serve as a novel cardioprotective agent against doxorubicin (DOX)-induced cardiotoxicity without affecting the antitumor activity of DOX. Chrysoeriol may be used for the prevention and treatment of vascular diseases and during restenosis after coronary angioplasty, it can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation. |
| CFN98786 | Savinin Savinin has antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. Savinin also exhibits potent spermicidal activity and significant insecticidal activity. |
| CFN90083 | Estriol 3-glucuronide Estradiol-3-glucuronide, estradiol-17beta-glucuronide, estriol-3-glucuronide , estrone glucuronide, estriol-16alpha-glucuronide, and pregnanediol-3alpha-glucuronide are immunoreactive metabolites of the major urinary estrogens, they have used to ovulation detection methods. |
| CFN90084 | 4-(p-Biphenylyl)-3-hydroxybutyric acid 4-(p-Biphenylyl)-3-hydroxybutyric acid shows anti-inflammatory activity. |
| CFN90085 | 7-Methoxy-1-tetralone 7-Methoxy-1-tetralone may have insecticidal activity. |
| CFN90086 | 7-Methoxy-1-naphthylacetonitrile 7-Methoxy-1-naphthyl-acetonitrile is an important intermediate in the preparation of anti-depression drugs. |
| CFN90087 | 7-Methoxy-1-naphthaleneacetic acid ethyl ester Reference standards. |
| CFN90088 | 7-Methoxy-1-naphthaleneacetic acid Reference standards. |
| CFN90089 | 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride |
| CFN90090 | 1-Chloroindan Reference standards. |
| CFN90091 | 1-Indanone 1-Indanone thiosemicarbazones coordinated to palladium(II) is more cytotoxic than those complexed with platinum(II); although platinum(II) is more selective for leukemic cells and has potential to treat hematological malignancies. |
| CFN98787 | Auraptene Auraptene possesses anticarcinogenic, cardioprotective, anti-inflammatory, anti-oxidant, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene has a potential to attenuate chronic inflammation in adipose tissue and to improve obesity-related insulin resistance, and has protective effects in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. |
| CFN98788 | Nodakenetin Nodakenetin has antioxidant activity, it displays the least irritant and least persistent reactions on mouse ears, and exhibits the least cytotoxic capacity against brine shrimp larvae. Nodakenetin angelate is used as an antiarthritic and nerve tonic. |
| CFN98789 | Angelicain Reference standards. |
| CFN98790 | Simiarenol acetate Reference standards. |
| CFN98791 | Resveratrol Resveratrol, a natural polyphenol that possesses anti-oxidant, anti-inflammatory, cardioprotective, blood-sugar-lowering, antiaging, and anti-cancer properties. It has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM, kinases, sirtuins, c-IAP1, c-IAP2, livin and XIAP. Resveratrol regulates gene transcription via activation of the stimulus-regulated protein kinases Raf and ERK and the stimulus-responsive transcription factors TCF and Egr-1. |
| CFN98792 | 2-(4-Hydroxyphenyl)ethanol Tyrosol [2-(4-hydroxyphenyl)ethanol] has neuroprotective, anti-oxidative and anti-inflammatory effects, it significantly protects dopaminergic neurons from MPP(+)-induced degradation. |
| CFN98793 | Rhododendrol Rhododendrol is an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, it can competitively inhibit mushroom tyrosinase and serve as a good substrate, while it also shows cytotoxicity against cultured human melanocytes at high concentrations sufficient for inhibiting tyrosinase. (+)-Rhododendrol and epi-rhododendrin have anti-inflammatory effect, they can suppress the NO production by activated macrophages in vivo. |
| CFN98794 | trans-4-Hydroxycinnamic acid Trans-4-hydroxycinnamic acid has antimicrobial, and anti-oxidant activities. |
| CFN98795 | Oleuropeic acid (+)-Oleuropeic acid shows potent in vitro antitumor-promoting activity, it also suppresses an in vivo two-stage carcinogenesis induced with nitric oxide and 12-O-tetradecanoyl phorbol 13-acetate (TPA) on mouse skin. |
| CFN98796 | Orcinol Orcinol glucoside is anxiolytic agent without sedative effect, it improves depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus. |
| CFN90092 | 1-Indanamine Reference standards. |
| CFN90093 | Propargyl benzenesulfonate Propargyl benzenesulfonate improves the SEI formation process. |
| CFN90094 | 2'',3''-Di-O-acetyl-5''-deoxy-5-fuluro-D-cytidine |
| CFN90095 | 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate,which is a key intermediate of capecitabine. |
| CFN90096 | Astaxanthin Astaxanthin is a strong antioxidant which shows neuroprotective property and can reduce the markers of inflammation, it can reduce matrix metalloproteinase expression in human chondrocytes, it may be beneficial in the treatment of osteoarthritis.Astaxanthin has protective effect on fetal alcohol spectrum disorder, and suggests that oxidative stress and TLR4 signaling associated inflammatory reaction are involved in this process. Astaxanthin administration can reduce renal calcium oxalate crystal deposition possibly by modulating the renal renin-angiotensin system (RAS), which reduces the expression of OPN and TGF-β1 levels. |
| CFN90097 | 3-Chloro-1-(4-octylphenyl)-propanone Reference standards. |
| CFN90098 | 3-Amino-3-(hydroxymethyl)-1-(4-octylphenyl)-1,4-butanediol Reference standards. |
| CFN90099 | 3-Nitro-1-(4-octylphenyl)-1-propanone Reference standards. |
| CFN90100 | 3-(Hydroxymethyl)-3-nitro-1-(4-octylphenyl)-1,4-butanediol Reference standards. |
| CFN98797 | Araneosol Standard reference |
| CFN98798 | Niranthin Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions. |
| CFN98799 | Vandrikidine Reference standards. |
| CFN98800 | Oleanolic acid Oleanolic acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor, anti-inflammatory, antioxidant, and antiviral properties. Oleanolic acid exhibits anti-HCV activity at least partly through suppressing HCV NS5B RdRp activity as a noncompetitive inhibitor; it induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways; can be employed as a lead in the development of potent NO inhibitors. Oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway. |
| CFN98801 | 13(18)-Oleanen-3-ol Standard reference |
| CFN98802 | Glutinone Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets. |
| CFN98803 | 14,15-Didehydroisoeburnamine Reference standards. |
| CFN98804 | Friedelanol Friedelanol and baccharis oxide may display an immunomodulatory action, they can increase reactive oxygen intermediate (H2O2) production by macrophages at a concentration of 100 uM. |
| CFN98805 | Rosenonolactone Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin. |
| CFN98806 | Thymidine Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. Thymidine could be a tracer in tumor cell examin. Thymidine overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues. |
| CFN98589 | Vincristine Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristine can treat MM, ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents for the treatment of Vincristine-resistant MM. An inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of Vincristine-related peripheral neuropathy. |
| CFN98590 | Rotenone Rotenone is a mitochondrial complex I inhibitor that produces an animal model of Parkinson's disease. Rotenone-induced α-synuclein aggregation is mediated by the calcium/GSK3β signaling pathway. Rotenone can increase intracellular levels of the toxic dopamine metabolite 3,4-dihydroxyphenyl-acetaldehyde (DOPAL), via decreasing DOPAL metabolism by aldehyde dehydrogenase (ALDH) and decreasing vesicular sequestration of cytoplasmic dopamine by the vesicular monoamine transporter (VMAT). |
| CFN98591 | Isoforsythiaside Isoforsythiaside has antioxidant, and antibacterial activities. |
| CFN98592 | Psoralidin Psoralidin possesses potent antidepressant-like, anti-inflammatory, anticancer and chemopreventive properties. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, it is also an agonist for both estrogen receptor (ER)α and ERβ agonist.Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways, it induces reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells. |
| CFN98593 | Isobavachalcone Isobavachalcone has anti-cancer, anthelmintic, antibacterial, aphrodisiac, anti-inflammatory, astringent and antiplatelet activities, Isobavachalcone can induce apoptotic cell death in neuroblastoma via the mitochondrial pathway; it can significantly inhibit both oligomerization and fibrillization of Aβ42; it can suppress inducible nitric oxide synthase (iNOS) expression induced by macrophage-activating lipopeptide 2-kDa, polyriboinosinic polyribocytidylic acid, or lipopolysaccharide. |
