Natural Products
| Catalog No. | Information |
| CFN98632 | 29-Hydroxyfriedelan-3-one Reference standards. |
| CFN98633 | p-Menth-1-ene-3,6-diol Standard reference |
| CFN98634 | Pinusolidic acid Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml). |
| CFN98635 | Yatein Yatein is a lignan precursor of podophyllotoxin, a key agent in anticancer drugs. Yatein can significantly suppress HSV-1 multiplication in HeLa cells without apparent cytotoxicity. |
| CFN98636 | Dadahol A Standard reference |
| CFN98569 | Rhaponiticin Rhaponticin(Rhaponiticin) has a noticeable antidiabetic effect and could be potentially used as a new agent to treat type 2 diabetes mellitus and its complications, it can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice. |
| CFN98570 | Cepharanthine Cepharanthine has anti-plasmodial, anti-tumor , anti-inflammatory, antiallergic, antioxidant, and immunomodulatory activities in vivo, and it is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection. |
| CFN98571 | Tricosanoic acid Tricosanoic acid is a long-chain fatty acid and shown to be a hair growth stimulant. Tricosanoic acid (23:0) could as internal standards in the quantitation of eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids. |
| CFN98572 | Octacosanoic Acid Octacosanoic Acid has antiplatelet and antithrombotic effects.Octacosanoic Acid ethylene glycol esters and glycerol esters are used as protective layer on fruit skins and coating on foods. |
| CFN98573 | Luteolin 7,3'-di-O-glucuronide Reference standards. |
| CFN98574 | Nystose Nystose has antioxidant capacity. Nystose and 1-Kestose can modulate the intestinal Microorganisms flora, a high content of kestose and nestose in the diet can cause a decrease in ileal and cecal pH (to 5.42 and 5.49, respectively)of turkeys, which may promote digestion. |
| CFN98575 | Benzoylmesaconine Benzoylmesconine has analgesic activity. Benzoylmesconine may improve the resistance of T6S-mice (or thermally injured mice) to the infection of HSV-1, through the induction of antagonistic CD4+ T cells against burn-associated type-2 T cells. |
| CFN98576 | Benzoylmesaconine hydrochloride Benzoylmesaconine hydrochloride has used as the reference standard to evaluate the quality of processed aconite root and powdered processed aconite root. |
| CFN98637 | Taxifolin 3-O-beta-D-xylopyranoside Reference standards. |
| CFN98638 | Nerolidol Nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs. Nerolidol shows anti-cancer, sedative, antiulcer, antifungal, and antifeeding effects. Nerolidol can inhibit the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 uM, respectively. |
| CFN98639 | 1,7-Diepi-8,15-cedranediol Reference standards. |
| CFN98640 | Sinoacutine Sinoacutine has protective effects against hydrogen peroxide-induced cell injury. |
| CFN98641 | Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of β-secretase, it is a potentially valuable antiamyloidogenic agent for the prevention and treatment of Alzheimer disease. (+)-Medioresinol has anti-bacterial, antifungal and anti-biofilm activities. |
| CFN98642 | Lipiferolide Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity. |
| CFN98643 | Skullcapflavone I Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I selectively induces apoptosis in T-HSC/Cl-6 cells via caspase-3 and caspase-9 activation. |
| CFN98644 | Platyphyllonol Platyphyllonol-5-xylopyranoside is moderately active against KBNP-0028 (H9N2) avian influenza virus as compared with zanamivir. |
| CFN98645 | Hirsutanonol Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation. Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells, it also has chemoprotective effect on human lymphocytes DNA. Hirsutanonol or oregonin as an active ingredient composition for treating atopic dermatitis, hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies. |
| CFN98646 | Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity. |
| CFN98577 | Benzoylaconine Benzoylaconine and aconitine can induce reproductive toxicity in BeWo Cell, the amino acid metabolism was the main metabolic pathway and responsible for the placental and fetal toxicity of them. |
| CFN98578 | Arenobufagin Arenobufagin is a potent Na + /K + pump inhibitor, and is also a specific inhibitor of VEGF-mediated angiogenesis. Arenobufagin has antineoplastic effect that involves cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway. |
| CFN98579 | Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways. |
| CFN98580 | Talatisamine Talatisamine is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities. Talatisamine (120 μM) and TEA (5mM) inhibits the enhanced I(K) caused by Aβ40 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. |
| CFN98581 | Deltaline Deltaline, enabling the synthesis of 32 new derivatives bearing a broad spectrum of unique scaffolds. |
| CFN98582 | Delsoline Delsoline has hypotensive effects.Delsoline is not only effective in preventing ventricular fibrillation and arrythmia, but can raise the intebsity of the threthold of electrical shocks to cause ventricular fibrillation in rabbits, the antiarrythmic effect of it may be mainly attributed to itsganglionic blocking and negative cardiac inotropic effect. |
| CFN98583 | 13-Dehydroxyindaconintine Reference standards. |
| CFN98584 | Denudatine Denudatine has effects on action potential of ventricular fibers and has inhibition on arrhythmogenic action of aconitine. |
| CFN98647 | Anhydrotuberosin Standard reference |
| CFN98648 | (-)-N-Methylsedridine Standard reference |
| CFN98649 | (+)-N-Methylallosedridine Standard reference |
| CFN98650 | Koaburaside monomethyl ether Standard reference |
| CFN98651 | 2,6,16-Kauranetriol Reference standards. |
| CFN98652 | 4,R-ajmalicine N-oxide Standard reference |
| CFN98653 | Lacinilene C Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through potential-dependent channels of smooth muscle cell membranes. |
| CFN98654 | Koaburaside Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells. |
| CFN98655 | Luteone Luteone possesses antifungal activity sufficient to support its proposed role as pre-infectional resistance factors. |
| CFN98656 | Acuminatin (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively.(-)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents. |
| CFN98585 | Maoecrystal A Maoecrystal A is a nartural from Rabdosia amethystoides. |
| CFN98586 | Hecogenin Hecogenin, a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. Hecogenin has anti-cancer, antiproliferative,antioxidant and anti-inflammatory effects, it can protect gastro by K⁺(ATP) channels opening and the COX-2/PG pathway. Hecogenin has inhibition of human rheumatoid arthritis synovial cell survival, the effect is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. |
| CFN98587 | Chasmanine Chasmanine, hypaconitine, and deoxyaconitine are anti-inflammatory pharmacodynamic components in Heishunpian (HSP) with positive relations with HSP efficacy. Chasmanine has insecticidal activities against larvae of Bradysia odoriphaga Yan et Zhang. |
| CFN98588 | Lycopene Lycopene is the pigment principally responsible for the characteristic deep-red color of ripe tomato fruits and tomato products. Lycopene is an antioxidant scavenger, hypolipaemic agent, inhibitor of pro-inflammatory and pro-thrombotic factors, thus potentially of benefit in cardiovascular disease (CVD). Lycopene may play a role in the prevention of Renal cell carcinoma, it also may play a role against obesity-related complications. |
| CFN90001 | 5-[(2R)-2-Aminopropyl]-2,3-dihydro-1-[3-(phenylmethoxy)propyl]-1H-indole-7-carbonitrile Reference standards. |
| CFN90002 | Silodosin Silodosin, a selective α-1a receptor antagonist, can increase passage of distal ureteral stones. Silodosin can temporarily improve lower urinary tract symptoms (LUTS), but do not improve the bladder outlet obstruction index (BOOI) after implantation in the prostate, it is a useful option for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia .Silodosin appears to suppress ejaculation in a relatively higher percent of trial participants, this suppression of ejaculation by silodosin suggested its potential for treating premature ejaculation. |
| CFN90003 | Agomelatine Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). Agomelatine is a melatonin (MT) analogue with agonistic properties and has been proven to be effective for various types of depressive symptoms, agomelatine also has anticonvulsant activity. Agomelatine treatment could represent a novel useful approach to the clinical care of subjects with Chronic Fatigue Syndrome (CFS). Agomelatine administration protects liver cells from paracetamol-induced hepatotoxicity via antioxidant activity and reduced proinflammatory cytokines, such as TNF-α and IL-6. |
| CFN90004 | Rasagiline mesylate Rasagiline mesylate is a potent, selective, non-reversible MAO-B inhibitor, with neuroprotective activities, with anti-Parkinson activity. Rasagiline mesylate exhibits neuroprotective and anti-apoptotic activity against several neurotoxins in cell culture. |
| CFN90005 | Fingolimod hydrochloride Fingolimod hydrochloride is an oral sphingosine-1-phosphate analogue that was approved by the FDA in 2010 for the treatment of relapsing forms of multiple sclerosis (MS). Fingolimod hydrochloride , a pak1 activator, can inhibit astemizole-induced hypertrophy and cytotoxicity in H9c2 cells, suggests that antihistamine-induced cardiac adverse effects are associated with pak1 expression and function.The gels containing 0.50% fingolimod hydrochloride (FNGL) and FNGL 0.50% plus 6% colloidal oatmeal have potential for the treatment of atopic dermatitis (AD). |
