Natural Products
| Catalog No. | Information |
| CFN98754 | Hyperoside Hyperoside, a naturally occuring flavonoid compound, exerts multiple bioactivities, including myocardial protection, anti-redox, neuroprotective, antifungal, hepatoprotective, anti-inflammatory and antioxidative effects. Hyperoside is a potent natural activator of Nur77 receptor, and a potent selective CYP2D6 inhibitor; it inhibited the HMGB1 signaling pathway, and inhibited the PI3K/Akt/Bad/Bcl XL -regulated mitochondrial apoptotic pathway. Hyperoside is a strong inhibitor of HBsAg and HBeAgsecretion in 2.2.15 cells and DHBV-DNA levels in the HBV-infected duck model. |
| CFN98755 | Tetrahydroamentoflavone Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent; it has anti-inflammatory effects, it shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2)). (2S,2″S )-Tetrahydroamentoflavone exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e). |
| CFN98756 | Kaempferitrin Kaempferitrin exerts immunostimulatory, antidepressant-like , antiosteoporotic , cytotoxic and antitumor effects, the general mechanisms include cell cycle arrest in G1 phase and apoptosis via intrinsic pathway in a caspase dependent pathway. Kaempferitrin is an acute lowering effect on blood glucose in diabetic rats and to stimulate the glucose uptake percentile, as efficiently as insulin in muscle from normal rats. |
| CFN90059 | Pimaricin Pimaricin is an effective, broad spectrum antifungal, it also exhibits reduced (oral and topical) toxicity to humans, which is probably associated with the lack of effects on mammalian cell membranes. |
| CFN90060 | Tartrazine Tartrazine is a food additive that belongs to a class of artificial dyes and contains an azo group; it has significant genotoxic effect , may be harmful to health and its prolonged use could trigger carcinogenesis. |
| CFN90061 | Sorbic acid Sorbic acid is important food preservatives and powerful fungistatic agents, it inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division). Sorbic acid is a more potent uncoupler of the membrane potential than acetic acid, the effect may also slow the rate of ATP synthesis significantly and may thus (partially) explain Sorbic acid's effectiveness. |
| CFN90062 | Sorbic acid, 1-p-tolylhydrazide Reference standards. |
| CFN90063 | Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries. |
| CFN90064 | Tetraethoxypropane 1,1,3,3-Tetraethoxypropane,the precursor of the ubiquitous natural compound malondialdehyde. Tetraethoxypropane as the standard in the thiobarbituric acid (TBA) assay. |
| CFN90065 | Sunset yellow Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care must be taken when using these materials as a food additive. |
| CFN90066 | Carmine Carmine is used in the manufacture of artificial flowers, paints, crimson ink, rouge, and other cosmetics, and is routinely added to food products such as yogurt, candy and certain brands of juice, the most notable ones being those of the ruby-red variety.There are many reported cases of immediate allergy after ingestion of foods containing cochineal and have a few reports of allergic contact dermatitis from carmine, suggests that carmine is an allergen. |
| CFN98757 | Afzelin Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin has potenial anti-cancer activity against prostate cancer, the activity is due to inhibition of LIM domain kinase 021 expression, it can inhibit the proliferation of LNCaP and PC302cells, and block the cell cycle in the G002phase. Afzelin can attenuate asthma phenotypes is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production. |
| CFN98758 | Imperatorin Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol); it is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Imperatorin is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. Imperatorin has anticonvulsant, anti-inflammatory, anti-oxidant, neuroprotection, and anti-cancer effects, it also has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. Imperatorin dampens neuronal excitability by inhibiting voltage-gated Na + channels (VGSC), and blocks the HSP27 and HSP72 gene expression. |
| CFN98759 | Sarpagine Sarpagine is effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells. |
| CFN98760 | Aricine Aricine has cytotoxicity. |
| CFN98761 | Ajmalicine Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure. |
| CFN98762 | Isorauhimbine 3-Epi-alpha-yohimbine(Isorauhimbine) has alpha adrenoceptor blocking activities,it also has cardiovascular effects. |
| CFN98763 | Sphondin Sphondin may have anticonvulsant, anti-inflammatory, and anti-proliferative activities, it may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions, it also possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells through suppression of NF-kappaB activity. Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti. |
| CFN98764 | Calycanthoside Isofraxidin-7-O-glucoside(Calycanthoside ) has the anti-inflammatory effect, it has inhibitory activity on NO production.It also shows antibacterial activity. |
| CFN98765 | Osthol Osthol is a natural antihistamine alternative, may be a potential inhibitor of histamine H1 receptor activity. Osthol has toxicity, may be used as bio-pesticides. Osthol is an inhibitor of human Pgp and multidrug efflux pumps of Staphylococcus aureus , reversing the resistance against frontline antibacterial drugs.Osthol has anti-allergic, antiosteoporosis, anti-fatty liver, antitumor, and cardioprotective effects. Osthol inhibits hepatic SREBP-1c/2 mRNA expressions and subsequent modulation of SREBP-1c/2-mediated target genes such as FAS, CYP7A and LDL receptor; it can stimulate the osteoblastic differentiation of rat calvarial osteoblast cultures by the BMP-2/p38MAPK/Runx-2/osterix pathway. |
| CFN98766 | Bergapten Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. Bergapten has anti-inflammatory and anti-tumor agent, it exhibits significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α(TNF-α) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharide in a concentration-dependent manner. Bergapten effectively prevents LPS-induced osteoclastogenesis, bone resorption and survival via apoptotic response of osteoclasts and their precursors. |
| CFN90067 | Riboflavine Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. Riboflavine exhibits anti-inflammatory, hepatoprotective, and antioxidant properties, can treat the regression of neurological impairment. Riboflavine deficiency may lead to angular conjunctivitis. |
| CFN90068 | Thiamine hydrochloride Thiamine hydrochloride is an efficient catalyst for the synthesis of amidoalkyl naphthols, it has prophylactic potential on lead induced lipid peroxidation in rat liver and kidney. Thiamine hydrochloride complex as a new anti-diabetic candidate. |
| CFN90069 | 3,3'',5-Triiodo-L-thyronine Sodium Salt The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M), a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. |
| CFN90070 | Homovanillic Acid Sulfate Homovanillic acid sulfate is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.In psychiatry and neuroscience, brain and cerebrospinal fluid levels of homovanillic acid are measured as a marker of metabolic stress caused by 2-deoxy-D-glucose. Homovanillic acid sulfate presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma. |
| CFN90071 | 1-Phenyloctane 1-Phenyloctane, 1-phenyldecane, 1-methylnaphthalene, and 2-methylnaphthalene, are four potential laser-induced fluorescence (LIF) tracers for diesel engine applications. |
| CFN90072 | Kynurenic acid Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.Kynurenic acid is the endogenous α7 nicotinic acetylcholine receptor antagonist, it has an immunomodulating effect, it can modulate amyloid-β-induced inflammation in BV-2 microglial cells. |
| CFN90073 | S-(5'-Adenosyl)-L-methionine chloride Reference standards. |
| CFN90074 | S-Adenosyl-L-methionine tosylate S-adenosyl-L-methionine tosylate has a beneficial effect on the outcome of ischemic injury by reducing the blood-brain barrier (BBB) breakdown and neuronal death. |
| CFN98767 | Reticuline Reticuline is a key compound in the biosynthetic pathway for isoquinoline alkaloids in plants, which include morphine, codeine and berberine. Reticuline possesses potent central nervous system depressant action, it (50-100 mg/kg i.p.) can produce alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and D-amphetamine-induced hypermotility and suppression of the conditioned avoidance response. (S)-Reticuline can elicit vasorelaxation probably due to the blockade of the L-type voltage-dependent Ca(2+) current in rat aorta, the effect may contribute to the potential cardioprotective efficacy of (S)-reticuline. |
| CFN98768 | Fraxinol Fraxinol is a natural product from Lobelia chinensis. |
| CFN98769 | Coclaurine (+)-R-Coclaurine and (+)-S-reticuline show negative inotropic effects, coclaurine derivatives and of paeoniflorin derivatives have neuromuscular blocking actions. D-Coclaurine has a neuroleptic-like property in blocking effects of dopaminergic stimulating agents. |
| CFN98770 | O-Acetylcyclocalopin A Standard reference |
| CFN98771 | Cyclocalopin A Cyclocalopin A and calopin B show potent free radical-scavenging activity against superoxide, DPPH, and ABTS radicals with IC (50) values of 1.2- 5.4 microg/mL.. |
| CFN98772 | Bergaptol Bergaptol acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.Bergaptol shows very good radical scavenging activity, it induces dose-dependent cytotoxic effect on MCF-7 cell viability. |
| CFN98773 | Vasicinone Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803. |
| CFN98774 | Daidzein Daidzein is a natural isoflavone phytoestrogen and a PPAR activator, used as a component of foods and dietary supplements, it should be a promising feed additive for production of high-quality beef meat. Daidzein has antitumor, anti-fibrotic, anti-bone loss, and anti-inflammatory effects. Daidzein inhibits TLR4-MyD88-NF-κB pathway. |
| CFN98775 | Pinoresinol Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C. elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1). |
| CFN98776 | Butein Butein is a chelator of ferrous and copper ions, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. Butein can inactivate PMA-activated AP-1, due to the blocking of JNK-mediated c-Jun phosphorylation through the inhibition of ATP binding. Butein has potent anticancer, anti-inflammatory, antioxidant activities, it also has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme. |
| CFN90075 | S-Adenosyl-L-Methtonine S-Adenosyl-L-methionine, L-methionine, and N-acetylcysteine exert various degrees of protection toward ethanol-induced cell injury, which are related to the efficiency of these compounds in maintaining a high glutathione pool. |
| CFN90076 | S-Adenosyl-L-Methionine iodide salt Reference standards. |
| CFN90077 | DL-Homocysteic acid DL-Homocysteic acid application disrupts calcium homeostasis and induces degeneration of spinal motor neurons in vivo. |
| CFN90078 | 1,5-Anhydro-D-glucitol 1,5-Anhydro-D-glucitol level might provide additional information to identify macroangiopathy of patients with type 2 diabetes, especially in those with excellent HbA1c levels. Low 1,5-Anhydro-D-glucitol levels are associated with vascular endothelial dysfunction, suggests it is a potentially useful marker for vascular endothelial dysfunction. |
| CFN90079 | Estriol Estriol (E3), an endogenous estrogen predominantly produced during human pregnancy, is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. E3 can blunt the postprandial glycemic surge in rats through modulating the level of intestinal glucose transporters. E3 exerts a mitogenic effect on T-47D and MCF-7 cells at concentrations of 10(-9)M (288 pg/ml) and higher. |
| CFN90080 | Estriol 3-sulfate Estriol 3-sulfate acts through the hydrolyzed E3, E3-17-S is inactive because it is not hydrolyzed, so Estriol 3-sulfate can play an important role in the biological responses of this mammary cancer cell line. |
| CFN90081 | Estriol 17-sulfate Estriol 17-sulfate stimulates PR very significantly in the MCF-7 human mammary cancer cell line E3 and E3-3-S. |
| CFN90082 | Estriol 3,17-dihexanoate Reference standards. |
| CFN98777 | Allitol Allitol is useful as a sweetener and the raw material for production of chemical compounds, it can be useful as a substrate for the production of L-form ketoses and aldoses. Allitol may be an important intermediate for the preparation of some medicines against diabetes, cancer, and viral infections, including AIDS. |
| CFN98778 | vibo-Quercitol (-)-vibo-Quercitol is a carbaglycosylamine glycosidase inhibitor. |
| CFN98779 | D-arabinitol D-arabinitol is a marker for the diagnosis of disseminated candidiasis and for monitoring response to antifungal therapy. |
