Natural Products
| Catalog No. | Information |
| CFN90321 | Cinnamic aldehyde Cinnamic aldehyde, a COX-2 inhibitor, exhibits cardioprotective, antidepressant-like, anti-leukemia, anti-oxidative and anti-inflammatory properties. Its supplementation can improve glucose and lipid homeostasis in diabetic animals. |
| CFN90322 | Araloside V Reference standards. |
| CFN90323 | Araloside X Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radicals. Aralosides have anti-inflammatory effect, they also can effectively prevent acute alcoholic liver injury. |
| CFN90324 | Cucurbitacin A Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase. |
| CFN90325 | Danshenxinkun A Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental adaptation and nervous system. Oleoyl danshenxinkun A also selectively inhibits rabbit platelet aggregation induced by arachidonic acid. |
| CFN90326 | Danshenxinkun B Danshenxinkun B has antioxIdant activity, it may have the potential of being used as natural antioxidants in foods and cosmetics. |
| CFN90327 | Danshenxinkun C Reference standards. |
| CFN97757 | Vinorine Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina. |
| CFN97758 | 2-Hydroxy-3,4,5,6-tetramethoxychalcone Reference standards. |
| CFN97759 | Paclitaxel Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats. |
| CFN97760 | Coniferyl alcohol Coniferyl alcohol restores the growth of KI-treated BY-2 cells and N. benthamiana seedlings, at high concentrations is toxic to plant cells. |
| CFN90328 | Danshenxinkun D Danshenxinkun D has antituberculosis H_(37)Rv activity in vitro. |
| CFN90329 | Daphnoretin Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way; it causes death of HOS cells by blocking cells successively in G2/M phases and activating the caspase-3 pathway. |
| CFN90330 | Dehydrocorydalin Dehydrocorydalin has anti-inflammatory,antinociceptive,antiplatelet,and anti-tumor effects and can protect the cardiovascular system. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP. |
| CFN90331 | Dihydrolycorine Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. It protects against anoxia damage of brain in rat.Dihydrolycorine-HCL shows hypotensive effects, it can block alpha 1-adrenoceptors. |
| CFN90332 | Dihydromethysticin Dihydromethysticin non-competitively inhibits the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels.The induction of CYP3A23 by dihydromethysticin and desmethoxyyangonin involves transcription activation, probably through a pregnane X receptor (PXR).-independent or PXR-involved indirect mechanism. |
| CFN97761 | 5,7-Dihydroxychromone 5,7-Dihydroxychromone is one of the active compounds that may contribute to regulate blood glucose levels. 5,7-Dihydroxychromone exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal. |
| CFN97762 | Raucaffricine Reference standards. |
| CFN90333 | 1,2-Dihydrotanshinquinone 1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. |
| CFN90334 | Emetine Hydrochloride Emetine hydrochloride and dehydroemetine combined with chloroquine in the treatment of children with amoebic liver abscess. |
| CFN90335 | 7-Ethyl-10-Hydroxycamptothecin 7-Ethyl-10-hydroxycamptothecin shows cytotoxicity against breast cancer, it efficiently target-bind to the colon and lungs of mice. |
| CFN97763 | Cyclomusalenone Cyclomusalenone is a potent α-glucosidase inhibitor. |
| CFN97764 | Deoxyelephantopin Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity, by inhibiting metastatic, inducing apoptosis, modulating oxidative stress , STAT3/p53/p21 signaling, MAPK pathway, PI3k/Akt/mTOR pathway, caspase cascades, and ROS . |
| CFN90336 | 7-Ethylcamptothecin 7-Ethylcamptothecin has the superior antitumor activity than camptothecin, it has a stronger growth-inhibiting activity against tumor cells and remains in the intestinal tract for a longer time and in higher amounts when administered in vivo. |
| CFN90337 | Farrerol Farrerol has antioxidative, anti-bacterial, anti-inflammatory, antiangiogenic activities, it is a potential candidate for the intervention of endothelial-injury-associated cardiovascular diseases. Farrerol inactivates KEAP-1 or activates the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduces the intracellular production of reactive oxygen species via the induction of HO-1 expression. Farrerol can inhibit angiogenesis through down regulation of Akt/mTOR, Erk and Jak2/Stat3 signal pathway, and can inhibit IL-1β-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-κB signaling pathway. |
| CFN90338 | Gaultherin Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, not in stomach and it left the cyclooxygenase-1 unaffected, which was the source of cytoprotective prostaglandins in gastric epithelium. |
| CFN90339 | Ginkgolic acid C15:0 Reference standards. |
| CFN90340 | 20(R)-Ginsenoside Rh2 20(R)-Ginsenoside Rh2, a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory. 20(R)-Ginsenoside Rh2 has anticancer, anti- proliferation, anti-inflammatory and antioxidative activities, it also shows selective osteoclastgenesis inhibitory activity. 20(R)-Ginsenoside Rh2 reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells. |
| CFN90341 | Harmine hydrochloride Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. |
| CFN90342 | Helicianeoide A |
| CFN90343 | Helicianeoide B Reference standards. |
| CFN97765 | Lamiide Lamiide has anti-inflammatory activity in carrageenin-induced paw edema test. It shows lipid peroxidation inhibition on rat-brain phospholipid peroxidation. |
| CFN97766 | Neoandrographolide Neoandrographolide has antiradical, anti-inflammatory,and hypolipidemic effects, it protects the cardiovascular without significant liver damage. Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.Neoandrographolide inhibits iNOS and COX-2 expression through inhibiting p38 MAPKs activation. |
| CFN90344 | Homoplantaginin Homoplantaginin shows anti-inflammatory and antioxidant properties, it also has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza. Homoplantaginin may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance, it ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway. |
| CFN90345 | Huperzine C Huperzine has the value as pretreatment of organophosphate poisoning, it can be used as a protective agent against organophosphate intoxication. |
| CFN90346 | 2-Hydroxyeupatolide 2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and make a contribution to further understanding the pharmaceutical activity of Eupatorium plants. |
| CFN90347 | Hydroxyevodiamine Reference standards. |
| CFN90348 | 3-Hydroxymethylenetanshinquinone Reference standards. |
| CFN90349 | 25(R)-Hydroxyprotopanaxadiol Reference standards. |
| CFN90351 | 25(S)-Hydroxyprotopanaxatriol Reference standards. |
| CFN90352 | 3alpha-Hydroxytanshinone IIA Reference standards. |
| CFN90353 | Hydroxytanshinone IIA Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger than the tanshinoneⅡA. |
| CFN90354 | Isochlorogenic acid C(4,5) Isochlorogenic acid C(4,5) has antiviral activity, including anti-HIV-1 integrase activity. It shows anti-hepatotoxic activity. |
| CFN97767 | Robtein Reference standards. |
| CFN97768 | Buergerinin G Standard reference |
| CFN90355 | Isocryptotanshinone Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. |
| CFN90356 | Isotanshinone I Isotanshinone I ,neotanshinone A and cryptotanshinone have different effects on inhibiting proteic activity of P38 and NF-κB signaling pathway,and this effect may be one of main mechanisms of inhibitive inflammation reaction by salvia miltiorrhiza bunge in liver. |
| CFN90357 | Isotanshinone IIA Isotanshinone IIA non-competitively inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 11.4±0.6 μM. PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. |
| CFN90358 | Isovanillin Isovanillin is a reversible inhibitor of aldehyde oxidase. It is largely used as pharmaceutical intermediates and also applied in food and beverage industry, synthetic fragrances, chemical. Isovanillin is a selective inhibitor of aldehyde oxidase, is metabolized by aldehyde dehydrogenase into isovanillic acid ,and the LD50 (rat, ipr) is 1276 mg/kg. |
| CFN90359 | Kaempferol-3-beta-O-glucuronide Kaempferol-3-beta-O-glucuronide has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal β-glucuronidase from various human cells. |
