Natural Products
| Catalog No. | Information |
| CFN90464 | Vincamine Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. Vincamine has contractile and relaxant actions on the guinea pig trachealis, may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution. Vincamine alleviates Amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells. |
| CFN90465 | Vindesine Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms. |
| CFN90466 | Vinleurosine Vinleurosine can partially inhibit the energy dependent transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. |
| CFN90467 | Vinpocetine Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. Vinpocetine can attenuate neointimal formation in diabetic rats and inhibit HG-induced VSMCs proliferation, chemokinesis and apoptotic resistance by preventing ROS activation and affecting MAPK, PI3K/Akt, and NF-κB signaling.Vinpocetine has anti-inflammatory activity, can treat inflammation and pain induced by a gram-negative bacterial component by targeting NF-κB activation and NF-κB-related cytokine production in macrophages. |
| CFN90468 | Syringetin-3-O-glucoside Reference standards. |
| CFN90469 | Cyanidin 3-sophoroside chloride Cyanidin-3-sophoroside has antioxidant capacity. |
| CFN90470 | Rebaudioside B Rebaudioside B tastes about 150 times sweeter than sucrose and it is non-caloric. |
| CFN90471 | Brassicasterol Brassicasterol may be a relevant additional biomarker in Alzheimer's disease (AD). |
| CFN90472 | Deapi-platycodin D Deapi-platycodin D has anti-inflammatory activity, it can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of APG as expectorants in diverse inflammatory pulmonary diseases. |
| CFN90473 | Tryptophan Tryptophan containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain.Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment. |
| CFN90474 | Danshenol B Danshenol B has aldose reductase(AR) inhibitory activity. |
| CFN90475 | Hupehenine Hupehenine is a natural product from Fritillaria thunbergii Miq. |
| CFN90476 | Anisic aldehyde Anisic aldehyde is a safe food additive for human, it has significant antifungal activity against Candida, including azole-resistant strains. |
| CFN90477 | Anisole Anisole is a flavouring agent that is a precursor to perfumes, insect pheromones, and pharmaceuticals. It is also a new dopant for atmospheric pressure photoionization mass spectrometry of low proton affinity, low ionization energy compounds. |
| CFN90478 | Chenodeoxycholic acid Chenodeoxycholic acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. Chenodeoxycholic acid could reverse obesity in cHF-fed mice, mainly in response to the reduction in food intake. |
| CFN90479 | Clinopodiside A Clinopodiside A is a natural product from Clinopodium chinense. |
| CFN90480 | Columbin Columbin has anti-inflammation activity, it has chemopreventive ability against human colon cancer, it also can inhibit growth of culture forms of Trypanosoma brucei. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. |
| CFN90481 | Cimicifugoside Cimicifugoside is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function. Cimicifugoside is also a phytoestrogen, it can selectively inhibit nicotinic acetylcholine receptor (nAChR) -mediated response in bovine chromaffin cells. |
| CFN90482 | Demethyl tetrandrine Demethyl tetrandrine and tetrandrine show inhibition on DNA synthesis, the 50% inhibition doses ( ID50 ) are in L7712 and Sl80 cells are 27.5, 24.5 mg/L and 2.6, 3 .5mg/ L , respectively. |
| CFN90483 | 4'-Demethylpodophyllotoxin 4'-Demethylpodophyllotoxin exhibits the remarkable cytotoxic potential in diverse cancer cell lines. |
| CFN90484 | Deoxynojirimycin hydrochloride 1-Deoxynojirimycin hydrochloride shows inhibitory activity against α-glucosidases, inhibitors of α-glucosidase are promising candidates for the development of antitype II diabetics and anti-AIDS drugs. |
| CFN90485 | alpha-Dihydroartemisinin Dihydroartemisinin is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs, is recommended as the first-line anti-malarial drug with low toxicity. Dihydroartemisinin possesses promising anticancer activities and induce cancer cell death through apoptotic pathways. |
| CFN90486 | Dracorhodin perchlorate Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate can inhibit high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin(FN) expression in human mesangial cells, and this may be part of the mechanism of preventing and treating renal fibrosis of DN. |
| CFN90487 | Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D and activates the expression of BmBR-C. Mnoaminergic autocrine signaling in the PG regulates Ecdysone biogenesis in a coordinated fashion on activation by PTTH and Ilps. |
| CFN90488 | Evodine Evodine may have antinociceptive activity. |
| CFN90489 | Geraniol Geraniol is a terpene alcohol occurring in the essential oils of several aromatic plants used in the flavour and fragrance industries. It also exhibits insecticidal and repellent properties and used as a natural pest control agent exhibiting low toxicity.Geraniol is a glutathion S transferase inhibitor, shows anticarcinogenic props. |
| CFN90490 | Hosenkoside C Hosenkoside C is a natural product from Impatiens balsamina L. |
| CFN90491 | 5-Isopropyl-2-methylphenol 5-Isopropyl-2-methylphenol presents anxiolytic, antinociceptive, and antidepressant effects, it seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems. |
| CFN90492 | Laurolitsine Reference standards. |
| CFN90493 | Lauric acid Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively. Lauric acid displays preferential antineoplastic property, including induction of apoptosis in a CRC cell line. |
| CFN90494 | Bornyl acetate Bornyl acetate shows highly active whitening and antioxidant activities, has potential applications in cosmeceutical materials. Bornyl acetate has anti-inflammatory activity, may be developed as a preventive agent for lung inflammatory diseases and osteoarthritis; it also has an antiabortive effect through modulation of immunological balance at maternal-fetal interface. |
| CFN92000 | Kushenol A Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). |
| CFN92001 | Kushenol I Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumerinum. |
| CFN92002 | Kushenol N Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells . |
| CFN92003 | Kurarinone Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response. Kurarinone sensitizes TNF-related apoptosis inducing ligand (TRAIL)-induced tumor cell apoptosis via suppression of NF-κB-dependent cFLIP expression; it may be by way of down-regulating Smad3 expression to interfere its induction on intercellular signal transduction and consequently ameliorate renal interstitial fibrosis. |
| CFN92004 | 2'-Methoxykurarinone 2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B, it exhibits cellular activity in the insulin signaling pathway by increasing the insulin-stimulated Akt phosphorylation level in human hepatocellular liver carcinoma HepG2 cells, suggesting its potential for new anti-insulin-resistant drug developments. 2′-Methoxykurarinone exhibits lethal activity against Trypanosoma cruzi.,the minimum lethal concentrations is 6.9 uM. |
| CFN92005 | Sophoraflavanone G Sophoraflavanone G has an anti-inflammatory effect, it has strong antimicrobial activity against mutans streptococci and could be useful in the development of novel oral hygiene products, such as a gargle solution or dentifrice. Sophoraflavanone G is a novel small-molecule inhibitor, it inhibits the NF-κB and MAPK signaling pathways. |
| CFN92006 | Kuraridine Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents. |
| CFN92007 | Hinokiflavone Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9. |
| CFN92008 | Eurycomanone Eurycomanone has anti-cancer activity, it is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2. |
| CFN92009 | Pasakbumin B Pasakbumin B is a natural product from Eurycoma longifolia. |
| CFN92010 | Canthin-6-one N-oxide Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities. |
| CFN92011 | 9-Methoxycanthin-6-one 9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL. |
| CFN92012 | 9-Methoxycanthin-6-one-N-oxide 9-Methoxycanthin-6-one-N-oxide shows cytotoxic activity against a panel of cell lines comprising a number of human cancer cell types. |
| CFN92013 | 7-Methoxy-beta-carboline-1-propionic acid 7-Methoxy-beta-carboline-1-propionic acid demonstrates significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains. |
| CFN92014 | Sappanone A Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 and NF-κB pathways, and may be a valuable compound to prevent or treat inflammatory diseases. |
| CFN92015 | Desmethylxanthohumol Desmethylxanthohumol shows estrogenic activity. |
| CFN92016 | 8-Prenylnaringenin 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity, it shows more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein. 8-Prenylnaringenin at all assayed doses (0.001-20 µM) presumably improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle. |
| CFN92017 | 6-Prenylnaringenin 6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin. It exhibits both mixed and non-competitive inhibitory characteristics against tyrosinase, tyrosinase is the rate-limiting enzyme for the production of melanin and other pigments via the oxidation of l-tyrosine. 6-Prenylnaringenin has anti-cancer potential , dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. 6-Prenylnaringenin can inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced inflammation (1μg/ear) in mice, it also exhibits inhibitory effects on skin-tumor promotion in anin vivo two-stagemouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]- anthracene (DMBA) as initiator and with TPA as promoter. |
| CFN92018 | 6,8-Diprenylnaringenin 6,8-Diprenylnaringenin is a natural product from Humulus lupulus. |
