Natural Products
| Catalog No. | Information |
| CFN97829 | 13-Epijhanol Reference standards. |
| CFN97830 | Cardenolide B-1 Standard reference |
| CFN97831 | Cerberic acid B Standard reference |
| CFN97832 | 2-Oxokolavenol Reference standards. |
| CFN97833 | 5,7,3'-Trihydroxy-4'-methoxy-8-prenylflavanone Reference standards. |
| CFN97834 | 8,14-Epoxyergosta-4,22-diene-3,6-dione (22E,24R)-8,14-epoxyergosta-4,22-diene-3,6-dione has antitumor activity, it may be disarming oncogenic pathways via direct modulation of the epigenetic machinery. |
| CFN97835 | 28-Deoxonimbolide 28-Deoxonimbolide exhibits potent cytotoxic activity against HL60 leukemia cells. |
| CFN97836 | 21,24-Epoxycycloartane-3,25-diol Reference standards. |
| CFN97837 | Methyl-Dodovisate A Methyl-Dodovisate A is a natural product from Dodonaea viscosa. |
| CFN97838 | 5,7,4'-Trihydroxy-3,6-dimethoxy-3',5'-diprenylflavone Reference standards. |
| CFN97839 | Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. |
| CFN97840 | Demethylmurrayanine O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml. |
| CFN97841 | Cinnamyl cinnamate Cinnamyl cinnamate is used as a fragrance ingredient. |
| CFN97842 | 3-Epimeliasenin B Reference standards. |
| CFN90449 | Praeruptorin E Praeruptorin E is a cardiotonic agent with selective cardiac calcium channel agonistic effect, it can relax swine coronary artery and decrease contractility in guinea-pig left atria. Praeruptorin E may be useful in the therapy of lung injury, it can protect mice from hydrochloric acid (HCl)-induced lung injury by inhibiting polymorphonuclear leukocytes (PMNs) influx, IL-6 release and protein exudation. |
| CFN90450 | alpha-L-Rhamnose Addition of the Rhamnose-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, inducing fast and transient increases in Ca2 influx and intracellular free Ca2 level. |
| CFN90451 | Schisanlactone E Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60. |
| CFN90452 | Sesamol Sesamol is regarded as a major antioxidant component in the oil with chemoprevention, radioprotective efficacy, anti-antiinflammary, antimutagenic, and antihepatotoxic activities. Sesamol inhibits melanin biosynthesis by down-regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis-related proteins through modulation of MITF activity, which promotes phosphorylation of p38 and JNK in melan-a cells. |
| CFN90453 | Sinigrin Sinigrin has antimicrobial activity. Sinigrin also exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats. |
| CFN90454 | Solanesol Solanesol can effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase; it also can protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70. |
| CFN90455 | Soyasaponin Aa Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα in 3T3-L1 adipocytes. |
| CFN90456 | Soyasaponin Bb Soyasaponin Bb can suppress Eca-9706 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways. |
| CFN90457 | L-Stepholidine L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti-dyskinesia effects. |
| CFN90458 | Syringaresinol-di-O-glucoside Syringaresinol-di-O-glucoside protects the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the stress-induced enlargement of adrenal gland. |
| CFN90459 | Szechenyine Szechenyine is a natural product from Aconitum brachypodum Diels. |
| CFN90460 | Tetrahydro tanshinone I Tetrahydro tanshinone I is one compound of Fufang Danshen Prescription (FDP) , liposome equilibrium dialysis system could simply and effectively esti-mate the absorption of multiple components in FDP in vivo, and predicts the potential bioactivity of these components, and thus contributes to the investigation of bioactive compounds with curative effect in FDP. |
| CFN97843 | 3-O-trans-p-Coumaroyltormentic acid 3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA). |
| CFN97844 | Sulfuretin Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways. Sulfuretin may have a potential role for neuroprotection, possibly through inhibition of phosphorylation of MAPK, PI3K/Akt, and GSK-3β, which leads to mitochondrial protection, NF-κB modulations and subsequent suppression of apoptosis via ROS-dependent pathwaysand, may be used as a therapeutic agent for PD; it also may have therapeutic value in preventing or delaying the progression of rheumatoid arthritis.Sulfuretin has therapeutical effect on leukemia, due to its potent apoptotic activity through the extrinsic pathway driven by a Fas-mediated caspase-8-dependent pathway. |
| CFN97845 | Floribundone 1 Standard reference |
| CFN97846 | 1-Hydroxy-1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)propan-2-one Reference standards. |
| CFN97847 | 8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate Reference standards. |
| CFN97848 | 9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid 9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. |
| CFN97849 | 29-Norcycloart-23-ene-3,25-diol 29-Norcycloart-23-ene-3,25-diol is a natural product from Aganosma marginata. |
| CFN97850 | Honyucitrin Standard reference |
| CFN97851 | Andrographidine E Andrographidine E is a natural product from Andrographis paniculata. |
| CFN97852 | Andrographidine C Standard reference |
| CFN97853 | Osthenone Osthenone shows strong activity against the cancer cell lines, whereas it has weak antiproliferative activity against the normal human cell lines. |
| CFN97854 | Narciclasine The alkaloid Narciclasine is the bioactive compound responsible for the anti-inflammatory action of HCE. Narciclasine displays marked proapoptotic and cytotoxic activity, as does pancratistatin, and significant in vivo anticancer effects in various experimental models, but it is also associated with severe toxic side effects. Narciclasine acts on the auxin signaling pathway upstream of TIR1, which modulates Aux/IAA protein degradation, and thereby affects the auxin-mediated responses in Arabidopsis roots, inhibits the root hair development of lettuce seedlings. |
| CFN97855 | Deacetylsalannin Deacetylsalannin shows antifeedant activity against Reticulitermes speratus Kolbe (95% protective concentration or PC95 = 1373.1 ug/disc). |
| CFN97856 | Annonacin Annonacin is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons; can cause significant cell death in various cancer cell lines. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases. |
| CFN97857 | cis-Dehydroosthol Standard reference |
| CFN97858 | Prostephanaberrine Prostephanaberrine is a natural product from Stephania japonica. |
| CFN97859 | Diacetylpiptocarphol Diacetylpiptocarphol shows antileishmanial activity against three stages of Leishmania infantum. |
| CFN97860 | Olivil monoacetate Prostephanaberrine is a natural product from Valeriana officinalis. |
| CFN97861 | Barpisoflavone A Barpisoflavone A possesses moderate estrogen partial agonistic activities and moderate antioxidant activities. |
| CFN97862 | Drevogenin A Standard reference |
| CFN97863 | Stilbostemin N Stilbostemins N may exhibit moderate antibacterial activities. |
| CFN90461 | Thermopsine Thermopsine exhibits antibacterial activity. |
| CFN90462 | Topotecan hydrochloride Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. Topotecan hydrochloride liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of Topotecan hydrochloride. |
| CFN90463 | Vanillin Vanillin is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.Vanillin can reversibly and non-competitively inhibit the cellulase activity at appropriate concentrations and the value of IC50 was estimated to be 30 g/L.Vanillin protects KSC from UVB irradiation and its effects may occur through the suppression of downstream step of MDM2 in UVB irradiation-induced p53 activation. Vanillin also inhibits yeast growth and fermentation. |
