Natural Products
| Catalog No. | Information |
| CFN97813 | Bisandrographolide C Reference standards. |
| CFN97814 | Bisandrographolide A Bisandrographolide A activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine. |
| CFN90253 | Nigranoic acid Nigranoic acid is able to promote NO production and stimulate phosphorylation of ERK1/2 through Ca(2+) influx, further impact expression of BDNF and c-fos, may be benefit to enhance mental and intellectual functions; it has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation.Nigranoic acid exhibits significant inhibitory activity against HNE with the IC50 value of 3.77 μM, and six esters displayed considerable inhibitory effects on HNE with IC50 values in the range of 2.61-8.95 μM. Nigranoic acid shows activity in several anti-HIV reverse transcriptase and polymerase assays. |
| CFN97815 | 14-Deoxy-11-hydroxyandrographolide 14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells. |
| CFN97816 | 5,19-Epoxy-19R,25-dimethoxycucurbita-6,23-dien-3-ol |
| CFN90365 | 11-Oxo-mogroside V 11-Oxo-mogroside V is a natural sweetener, exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O2-, H2O2 and *OH) with EC50 of 4.79, 16.52, and 146.17 μg/mL, respectively. 11-Oxo-mogroside V exhibits the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. |
| CFN90366 | 11-Hydroxy-sugiol Reference standards. |
| CFN90367 | 12-O-tetradecanoylphorbol-13-acetate 12-O-tetradecanoylphorbol-13-acetate has skin tumor-promoting potential, it induces endogenous FBXO10 mRNA and FBXO10 protein in Jurkat cells, a human T cell line. It provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner. |
| CFN90368 | 12-O-Tiglylphorbol-13-isobutyrate 12-O-Tetradecanoylphorbol-13-acetate has cytotoxic against in vitro P-388 lymphocytic leukemia and KB nasopharyngeal carcinoma cell. |
| CFN90369 | 3Beta-acetoxy-eupha-7,25-dien-24(R)-ol Reference standards. |
| CFN90371 | 7-Epitaxol 7-Epitaxol is the major derivative of taxol found in cells and taxol (paclitaxel) is a well-known natural-source cancer drug. |
| CFN90372 | Broussonetine A Broussonetines A-H are glycosidase inhibitors. |
| CFN90373 | Crassicauline A Crassicauline A, a diterpenoid alkaloid in Aconitum herbs, is an analgesic drug clinically used in China. Crassicauline A possesses feeding deterrent activity against T. castaneum adults, with the EC(50) value of 1134.5 ppm. |
| CFN90374 | Crovatin Reference standards. |
| CFN90375 | Croverin Reference standards. |
| CFN90376 | Cucurbitacin IIb Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. Cucurbitacin IIb exhibits its anti-inflammatory activity through modulating multiple cellular behaviors and signaling pathways, leading to the suppression of the adaptive immune response. Cucurbitacin IIb also can induce apoptosis of concanavalin A-activated mouse lymphocytes. |
| CFN90377 | Hosenkoside F Hosenkoside F is a natural product from Impatiens balsamina L. |
| CFN90378 | Eupalinilide B Eupalinilides B demonstrates potent cytotoxicity against P-388 and A-549 tumor cell lines. |
| CFN90379 | Eupalinilide C Eupalinilide C is a natural product from Impatiens balsamina L. |
| CFN90380 | Eupalinilide D Eupalinilide D is a natural product from Impatiens balsamina L. |
| CFN90381 | Eupalinolide A Eupalinolide A and Eupalinolide B induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. They could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production. |
| CFN90382 | Eupalinolide B Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Eupalinolide B and Eupalinolide A induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90, they could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production. |
| CFN90383 | Garcinone D Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 activation with IC50 values of 3.2 microM. |
| CFN90384 | Huzhangoside D Huzhangoside D shows insecticidal activities against termite (Coptotermis homii), the LC50 of 0.2 mg/mL. |
| CFN90385 | Isomangiferin Isomangiferin has antioxidant and radical-scavenging activities; it also has antiviral effect, may due to its capability of inhibiting virus replication within cells. |
| CFN90386 | Jaceosidin Jaceosidin has immunosuppressive, anti-oxidative, anti-inflammatory, and anticancer activities, it is also a microglial inhibitor with anti-neuroinflammation activity. Jaceosidin modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin inhibits T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway. |
| CFN90387 | Khasianine Khasianine exhibits strong activity against liver damage induced by CCl4. |
| CFN90388 | Levatin Reference standards. |
| CFN90389 | Mogroside IV Mogrosides IV is a sweet minor cucurbitane glycoside, it exhibits maltase inhibitory effect. Mogroside IV, Mogroside V and combinations thereof act as a Toll -Like Receptor -4 agonist and immune stimulant that can be utilized for both therapeutic vaccine design in cancer and for other pathogenic agents; therapy with Mogroside IV, Mogroside V and combinations thereof are also presented to created immune clearance of a viral infection. |
| CFN90390 | Magnesium Lithospermate B Magnesium lithospermate B is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase, it provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion. Magnesium lithospermate B has potent antifibrotic effect in intraperitoneal thioacetamide (TAA)-treated cirrhotic rats, and inhibits fibrogenic responses in hepatic stellate cells (HSCs). It has depressor action on blood pressure in spontaneously hypertensive rats.Magnesium lithospermate B also has anti-wrinkle and anti-aging effects on skin. |
| CFN97817 | Myricetin 3-O-galactoside Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral inhibition of nitric oxide synthesis, mainly inducible nitric oxide synthase (iNOS). |
| CFN97818 | Mupinensisone Standard reference |
| CFN97819 | 11,13-Dihydroivalin Standard reference |
| CFN97820 | Dehydroadynerigenin beta-neritrioside Reference standards. |
| CFN97821 | Clausine D Clausine D and clausine F show significant antiplatelet aggregation activity, due to inhibition of the formation of thromboxane A2. |
| CFN97822 | 14-Deoxy-11,12-didehydroandrographiside Standard reference |
| CFN90391 | Prosapogenin CP4 Prosapogenin CP4 is a natural product from Anemone hupehensis Lemoine. |
| CFN90392 | Prosapogenin CP6 Reference standards. |
| CFN90393 | Napellonine Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays. |
| CFN90394 | Obtusifolin Obtusifolin is a novel anti-breast-cancer bone metastasis agent, which has antioxidant, and antinociceptive properties.Obtusifolin has beneficial effects on the development of diabetic retinopathy via inhibition of accumulation of oxidatively modified DNA and nitrotyrosine in the retina, can help prevent vision loss in diabetic patients. Gluco-Obtusifolin and its aglycone may be useful for the treatment of cognitive impairment, and that its beneficial effects are mediated, in part, by the enhancement of cholinergic signaling. |
| CFN90395 | Olaquindox Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induces apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway, might be suppressed through p38 MAPK and ROS-JNK pathways; it induces autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK.Olaquindox has genotoxic activity. |
| CFN90396 | Dipsacussaponin PE Reference standards. |
| CFN90397 | Pterostilbene Pterostilbene acts as a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, it has been implicated in anticarcinogenesis, antioxidant, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. Pterostilbene downregulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK. Pterostilbene may protect HUVECs against oxLDL-induced apoptosis by downregulating LOX-1-mediated activation through a pathway involving oxidative stress, p53, mitochondria, cytochrome c and caspase protease. |
| CFN97823 | Isomurralonginol acetate Standard reference |
| CFN97824 | Tristin Tristin shows stronger antioxidative activity than butylated hydroxyanisole (BHA). |
| CFN97825 | Rutaretin Standard reference |
| CFN97826 | 3,4'-Dihydroxy-3',5'-dimethoxypropiophenone 3,4'-Dihydroxy-3',5'-dimethoxypropiophenone is a natural product from Cinnamomum camphora. |
| CFN90398 | Siamenoside I Siamenoside I is one of the mogrosides that has several kinds of bioactivities, it exhibits maltase inhibitory effect with the IC50 value of 12 mM. |
| CFN90399 | Tanshinone IIA-sulfonic sodium Tanshinone IIA sulfonate (sodium) is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.Sodium tanshinone IIA sulfonate pretreatment reduces infarct size and improves cardiac function in an ischemia-reperfusion-induced rat myocardial injury model via activation of Akt/FOXO3A/Bim-mediated signal pathway. |
| CFN97827 | 8-Prenyldaidzein 8-Prenyldaidzein has cytotoxic properties against P-388 cells, its IC 50 values 5.82 ug/mL, it also exhibits very high antioxidant activity against DPPH radical scavenging. |
