Natural Products
| Catalog No. | Information |
| CFN92166 | Sageone Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity. |
| CFN92167 | Danshenol A Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines. |
| CFN92168 | 15-Epi-Danshenol-A Reference standards. |
| CFN92169 | Saprorthoquinone Saprorthoquinone is a natural product from Salvia prionitis. |
| CFN92170 | Pelargonidin-3,5-O-diglucoside chloride Pelargonidin-3,5-O-diglucoside chloride has antioxidant activity. It also has radioprotective effect and the absence of the toxic effect . |
| CFN92171 | Delphinidin-3-sambubioside chloride Delphinidin-3-sambubioside chloride has antioxidant activity. Delphinidin-3-sambubioside might induce apoptosis in HL-60 cells through a ROS-mediated mitochondrial dysfunction pathway. |
| CFN92172 | Quercetin-3-O-glucuronide Quercetin-3-O-glucuronide is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities. Quercetin-3-O-glucuronide significantly improves Alzheimer's disease (AD)-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation, possibly through mechanisms involving the activation of the c-Jun N-terminal kinases and the mitogen-activated protein kinase signaling pathways. Quercetin-3-O-glucuronide is equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function. |
| CFN92173 | Cyanidin-3-O-sambubioside chloride Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NFκB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging property. |
| CFN92174 | 1,2-Benzenedicarboxylic acid 1,2-Benzenedicarboxylic acid is one kind of allelochemical shows stronger allelopathic effect on itself than on wheat and pigeonpea. 1,2-Benzenedicarboxylic acid has antimicrobial activity, it shows anti-extended-spectrum beta-lactamases (ESBL) activity. |
| CFN92175 | 20-Deoxocarnosol 20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity. |
| CFN92176 | 3-Oxosapriparaquinone 3-Oxosapriparaquinone is a natural product from Salvia prionitis. |
| CFN92177 | 6-Hydroxysugiol 6-Hydroxysugiol inhibits proliferation and migration of HepG2 cells and exhibits potent anti-angiogenic activity. |
| CFN92178 | Ferruginol Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells. Ferruginol has antimicrobial and antifungal activities against wood-rot fungi (basidiomycetes), can cause cellular dysfunction and damage, lead to growth inhibition and autophagic cell death of fungi. |
| CFN92179 | Methylenetanshinquinone Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. |
| CFN92180 | Microstegiol Migrostegiol has a little activity against B. subtilis. |
| CFN92181 | Neocryptotanshinone Neocryptotanshinone inhibits rabbit platelet aggregation induced by arachidonic acid. |
| CFN92182 | Prionoid C Prionoid C is a natural product from Salvia prionitis. |
| CFN92183 | Prionoid D Prionoid D (IC50 = 0.41 microM) shows significant cytotoxic activity against P-388 cell lines. |
| CFN92184 | Prionoid E Prionoid E (IC50 = 0.72 microM) shows significant cytotoxic activity against A-549 cell lines. |
| CFN92185 | Salprionin Salprionin is a natural product from Salvia prionitis. |
| CFN92186 | Salvicine Salvicine has antimetastatic activity and shed new light on the complex roles of ROS and downstream signaling molecules, particularly p38 MAPK, in the regulation of integrin function and cell adhesion. Salvicine has potent anti-angiogenic activity through the inhibition on the sequential angiogenic cascades: proliferation, migration and tube formation and is associated with influence on the expression of bFGF of tumor cell.Salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. |
| CFN92187 | Sugiol Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals. Sugiol's efficacy in inhibiting the inflammatory cytokines of IL-1beta and TNF-alpha could be attributed to a reduction of the ROS that leads to a decrease in the phosphorylation of MAPKs. |
| CFN90498 | Cycloart-23-ene-3,25-diol Cycloart-23-ene-3,25-diol has anti-inflammatory activity, it has protective activity against streptozotocin induced toxicity. Cycloart-23-ene-3,25-diol treatment can decrease liver malondialdehyde but increase superoxidase dismutase and reduced glutathione. |
| CFN92188 | Mogroside IVa Mogroside IVa is a natural product from Siraitia grosvenorii Swingle. |
| CFN92189 | Mogroside IVe Mogroside IVe can inhibit the proliferation of HT29 and Hep-2 cells in culture and in xenografted mice in a dose-dependent manner, which is accompanied by the upregulation of tumor suppressor p53, and downregulation of matrix metallopeptidase 9 (MMP-9) and phosphorylated extracellular signal-regulated kinases (ERK)1/2. |
| CFN92190 | Mogroside III The human intestinal bacteria shows potent ability to transform Mogroside III to release secondary glycoside mogroside II(A1) and aglycone mogrol. |
| CFN92191 | Mogroside IIe Mogroside IIe is a bitter triterpenoid saponin which is the main component of unripe Luo Han Guo fruit and a precursor of the commercially available sweetener mogroside V. |
| CFN92192 | 11-Oxomogroside III 11-Oxomogroside III is a natural product from Siraitia grosvenorii Swingle. |
| CFN92193 | Mogroside III-A1 Mogroside III-A1 is a natural product from Siraitia grosvenorii Swingle. |
| CFN92194 | 3-oxo-Olean-12-en-28-oic acid 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL. |
| CFN92195 | Polygalic acid Polygalic acid, a triterpenoid saponin, shows expectorant, emetic and stimulant effects. |
| CFN92196 | 3-Epiursolic acid 3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 uM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents. |
| CFN92197 | Mahanimbine Mahanimbine inhibits AChE activity in a dose-dependent manner. Mahanimbine can lower the absorption of dietary fat resulting in dietary fat excretion, it can prevent high-fat diet (HFD)-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine and mangiferin increases the glucose utilization in a dose-dependent manner, can prevent obesity and use in management of diabetes. |
| CFN92198 | Isomahanimbine Isomahanimbine shows protection in liver. |
| CFN92199 | Mahanine Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, is an encouraging therapeutic choice for advanced prostatic cancer. |
| CFN92200 | Isomahanine Isomahanine and mahanine show antibacterial activity towards Flavobacterium columnare and Streptococcus iniae which caused columnaris disease and streptococcosis respectively; isomahanine has the strongest activity against F. columnare (isolate ALM-00-173) and S. iniae (isolate LA94-426) based on 24-h 50% inhibition concentration (IC50) and minimum inhibition concentration (MIC). Isomahanine is also a potent inhibitor of sEH , with IC50 values of 22.565±651.7. |
| CFN92201 | Murrayanol Murrayanol has antioxidant activity. It shows an IC50 of 109 μg/mL against hPGHS-1 and an IC50 of 218 μg/mL against hPGHS-2 in antiinflammatory assays. |
| CFN92202 | Chiirirhamnin Chiirirhamnin is a natural product from Aconitum chiisanense. |
| CFN92203 | Mogroside II-A2 Mogroside II-A2 is a natural product from Siraitia grosvenorii Swingle. |
| CFN92204 | Campesterol Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory effect, it inhibits several pro-inflammatory and matrix degradation mediators typically involved in osteoarthritis- induced cartilage degradation, also sometimes used to treat some specific prostate conditions. |
| CFN92205 | Picrasidine Q Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells. |
| CFN92206 | 7-Hydroxy-beta-carboline-1-propionic acid 7-Hydroxy-beta-carboline-1-propionic acid shows cytotoxic activity. |
| CFN92207 | Platycodigenin Platycodigenin has in vitro anti-proliferative activity against the HSC-T6 cell line. |
| CFN92208 | 3-beta-O-(cis-p-Coumaroyl)maslinic acid 3-beta-O-(trans-p-Coumaroyl)maslinic acid shows antimicrobial activity on Gram-positive bacteria and yeasts. |
| CFN92209 | 3-beta-O-(cis-p-Coumaroyl)corosolic acid Reference standards. |
| CFN92210 | 3-beta-O-(trans-p-Coumaroyl)maslinic acid 3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B" inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts. |
| CFN92211 | 3-O-cis-p-Coumaroyltormentic acid 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca-noylphorbol-13-acetate (TPA). |
| CFN92212 | Schisanlactone A Schisanlactone A is a dimerization inhibitor, with an IC50 value of 5.0 microg/mL; it also shows appreciable inhibitory activity against HIV-1 protease with the IC50 value of 20 microM. Schisanlactone A shows cytotoxicity against KB (a human epidermal carcinoma) cells with the IC50 value of 63.3 uM. |
| CFN92213 | Kadsuric acid 3-methylester Kadsuric acid 3-methylester is a natural product from Kadsura longipedunculata Finet.et Gagnep. |
| CFN92214 | Viscidulin II Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β production in THP-1 cells, concomitant intradermal injection of viscidulin II with P. acnes can effectively attenuate P. acnes-induced ear swelling, and decrease the production of IL-6 and tumor necrosis factor-α in ear homogenates. |
