Natural Products
| Catalog No. | Information |
| CFN90887 | Isopropylidenylacetyl-marmesin Reference standards. |
| CFN90890 | 3,4-Dihydrocoumarin 3,4-Dihydrocoumarin is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items; as a fragrance in perfumes, creams, and cosmetics. |
| CFN90891 | Harringtonine Harringtonine , an anticancer drug with high chemotherapeutic efficiency to human chronic granulocytic/myelomonocytic leukemia, has been reported to rapidly induce apoptosis in HL-60 cells in a wide scope/range of dosage by investigators from our lab and others. Harringtonine exerts its antiviral effects by inhibiting Chikungunya virus (CHIKV) viral protein synthesis. |
| CFN95013 | (R)-Reticuline (R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids. |
| CFN90893 | Mosloflavone Mosloflavanone is an antifungal and radical scavenging 2-hydroxyflavanone, it possesses strong anti-EV71 activity and decreased the formation of visible cytopathic effects, it also inhibits virus replication during the initial stage of virus infection, and inhibits viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; it shows dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. |
| CFN90894 | 4-(4-Hydroxyphenyl)-2-butanone 4-(4-Hydroxyphenyl)-2-butanone(Raspberry ketone,RK) is widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff, it also shows PPAR-α agonistic activity. It is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can cause chemical/occupational leukoderma. |
| CFN90895 | Triacetylresveratrol Triacetylresveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells. |
| CFN96484 | Corynoxidine Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains. It inhibits acetylcholinesterase activity in a dose-dependent manner, and the IC50 value of 89.0 microM. |
| CFN90896 | Chrysin dimethylether Chrysin dimethylether shows moderate activity against Trypanosoma brucei, and the IC50s less than 5.0 microg/ml. |
| CFN96485 | Steviolbioside Steviolbioside is a natural sweetener, it presents notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3, thus, steviolbioside could be a potential remedy for human breast cancer. Steviolbioside also exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro. |
| CFN96486 | Methyl 2,4-dihydroxyphenylacetate Reference standards. |
| CFN96487 | Indole-3-glyoxylamide Indole-3-glyoxylamides are an attractive lead series for continuing development as potential therapeutic agents against prion disease. A number of Indole-3-glyoxylamides have previously been reported as tubulin polymerization inhibitors, exert a cytotoxic effect against multiple cancer cell lines. |
| CFN96488 | Gallocatechin gallate Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabetic effects by increasing sensitivity of insulin. Gallocatechin gallate can decrease osteoclastogenesis at 20 microM, it has positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations. |
| CFN96489 | Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells. |
| CFN96490 | Hematoxylin Hematoxylin and eosin (H+E) are pigments, they are used to morphological assessment. |
| CFN96491 | Procyanidin A2 Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 diabetes activities. Procyanidin A2 demonstrates liver cell regenerative activity in scratch wound healing assays and alcohol-induced liver cell injury in vitro. |
| CFN96492 | Nevadensin Nevadensin is an important herb-based constituent inhibiting estragole bioactivation. Nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat. It also exhibits inhibition activity against Mycobacterium tuberculosis, with equal MIC value of 200 microg/mL. |
| CFN96493 | 5,7-Dihydroxy-3',4',5'-trimethoxyflavone 5,7-Dihydroxy-3',4',5'-trimethoxyflavone is a natural product from Centaurea scoparia. |
| CFN96494 | Taxifolin 3'-O-glucoside Taxifolin 3'-O-glucoside is a natural product from Chamaecyparis obtuse. |
| CFN96495 | Procyanidin A1 Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2⁺ influx from an internal store in RBL-2H3 cells. Procyanidin A1 shows a very high inhibition effect on LDL oxidation, with the IC50 value of 0.94 uM. |
| CFN96496 | Plathymenin Plathymenin is a natural product from Spatholobus suberectus. |
| CFN96497 | Garbanzol Garbanzol is a natural product from Cicer arietinum. |
| CFN96498 | Corymbosin Corymbosin shows significant antiviral activity. |
| CFN96499 | Alpinumisoflavone acetate Alpinumisoflavone strongly inhibits germ tube growth at 0.63 ug/disc. |
| CFN96500 | (+/-)-Vestitol Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries. Vestitol inhibits neutrophils migration in the inflammatory process. |
| CFN96501 | Sativan Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL. |
| CFN96502 | Poriol Poriol is a natural product from Cephalotaxus sinensis. |
| CFN96503 | Pilloin Pilloin exerts a cytotoxic action targeted at the transformed lymphoblasts. |
| CFN96504 | Licoricone Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. |
| CFN96505 | Isoangustone A Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. |
| CFN96506 | Eucomol Eucomol is a natural product from Eucomis vandermerwei. |
| CFN96507 | Cirsimarin Cirsimarin shows antioxidant activity; it also exerts potent antilipogenic effect and decreases adipose tissue deposition in mice, it could therefore be a potential candidate for the treatment of obesity. |
| CFN96508 | Cirsiliol Cirsiliol shows antioxidant, and anti-obesity effects, it can inhibit TG accumulation in 3T3-L1 preadipocytes. Cirsiliol and rhamnetin can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways. |
| CFN96509 | Bonducellin Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial activity against Plasmodium falciparum with the IC50 value of 26 uM; it also shows weak antiproliferative against A2780 human ovarian cancer cell line , with the IC50 value of 10.6 uM. Bonducellin shows modulation in the MIC of EtBr by eight fold at a concentration of 62.5 mg/L and also shows significant efflux pump inhibitory activity. |
| CFN96510 | Arteanoflavone Arteanoflavone is a natural product from Artemisia hispanica. |
| CFN96511 | Abyssinone V Abyssinone V is a protein tyrosine phosphatase-1B (PTP1B) inhibitor, it inhibited PTP1B activity, with IC50 values ranging from 14.8 +/- 1.1 to 39.7 +/- 2.5 microM. |
| CFN96512 | 7,8-Dihydroxyflavone 7,8-Dihydroxyflavone(7,8-DHF) shows vasorelaxing , antihypertensive, anti-inflammatory and anti-oxidant properties, it can be used as a potent facultative ingredient in health-beneficial agents to prevent or treat the skin aging or inflammatory skin disorders. 7,8-DHF has anti-obesity activity, it improves mitochondrial respiration in STs from obese women, it is beneficial for both depression and anxiety-like behaviors, and may exert fast-onset antidepressant effects. 7,8-DHF exhibits anti-melanogenic activity through inhibition of tyrosinase activity in α-MSH-stimulating condition, it also shows anticancer activity in melanoma cells via downregulation of α-MSH/cAMP/MITF pathway. 7,8-DHF ameliorates motor deficits via suppressing α-synuclein expression and oxidative stress in the MPTP-induced mouse model of Parkinson's disease. |
| CFN96513 | Sophoraisoflavone A Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced protein oxidative modification of mice brain homogenate in vitro. |
| CFN96514 | Sikokianin C Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL. |
| CFN96515 | Licoflavonol Licoflavonol is a novel natural inhibitor of Salmonella T3SS, could be a promising candidate for novel type of anti-virulence drugs, it exhibits a strong inhibitory effect on the secretion of the SPI-1 effector proteins via regulating the transcription of the SicA/InvF genes, and the transportation of the effector protein SipC. |
| CFN96516 | Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. |
| CFN96517 | 7-O-Methyleucomol 7-O-Methyleucomol is a natural product from Eucomis bicolor Bak. |
| CFN96518 | 7,3'-Di-O-methylorobol 7,3'-Di-O-methylorobol is a natural product from Sophora japonica L. |
| CFN96519 | 3,9-Dihydroeucomin (+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM. |
| CFN96520 | Topazolin Topazolin has weak fungitoxic activity, it displays significant activity against Salmonella typhimurium ATCC 13311 with MIC values ranging from 2 to 8 ug/mL, it also shows in vitro free radical scavenging activities with IC50 values in the range of 0.18-0.56 mg/mL. |
| CFN96521 | Maackiaflavanone Maackiaflavanone B shows cytotoxic activity with IC(50) value of 7.8 microM against human cancer cell line A375S2. |
| CFN96522 | Isolupalbigenin Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection. |
| CFN96523 | Glyasperin D Glyasperin D possesses weak anti-Helicobacter pylori activity. |
| CFN96524 | Gancaonin G Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans. |
| CFN96525 | Euchrestaflavanone B Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of protein kinase CKII activity. |
