Natural Products
| Catalog No. | Information |
| CFN90798 | Hydroxycitric acid (-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. Hydroxycitric acid ameliorates high-fructose-induced redox imbalance and activation of stress sensitive kinases in male Wistar rats through its hypolipidemic effects. |
| CFN93276 | Irigenin Irigenin, an α-glucosidase inhibitor, which has anti-inflammatory, anti-cancer, and anti-metastatic effects. Irigenin can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable cytotoxic effect. Irigenin displays moderate activity as inducers of NAD(P)H:quinone reductase (QR) in cultured mouse Hepa 1c1c7 cells. |
| CFN92450 | Methylsynephrine Hydrochloride Reference standards. |
| CFN93282 | Notoginsenoside Fe Notoginsenoside Fe can induce gap junction-mediated intercellular communication (GJIC) reductions; and gap junctions have been shown or are believed to be involved in the pathogenesis of many inherited and acquired human diseases, agents that regulate the GJIC function may facilitate prevention and treatment of GJIC-involved diseases. |
| CFN90799 | Arecoline hydrobromide Arecoline hydrobromide is formerly used as a cholinergic agent, it is a hypotensive agent. Arecoline hydrobromide is purgative, vermifuge and taenifuge agents in veterinary medicine. It induces rat hepatic CYP2 B by promoting nuclear translocation of CAR, the regulation of it on rat hepatic CYP2 B largely involve transcriptional activation of the gene,partially involve the post-translational modification of CYP2 B protein. |
| CFN93610 | alpha-Carotene alpha-Carotene has anti-metastasis activity, it inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO. |
| CFN93803 | 4-O-beta-Glucopyranosyl-cis-coumaric acid Reference standards. |
| CFN93559 | Camelliaside A Camelliaside A is a natural product from Camellia oleifera Abel. |
| CFN93532 | Desmethylbellidifolin Dimethylbellidifolin shows mutagenicity in Salmonella typhimurium TA100, TA98, TA97, and TA2637 by the preincubation method; it also exhibits at the dose of 200 ug/disk a significant inhibition of the growth of Staphylococcus aureus. Desmethylbellidifolin exhibits at the dose of 200 ug/disk a significant inhibition of the growth of Staphylococcus aureus. |
| CFN93455 | 6''-O-Acetylglycitin 6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor. |
| CFN93410 | Purpureaside C Purpureaside C has significant proinflammatory, antimicrobial and immunomodulating effects. |
| CFN93215 | Kukoamine A Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats. Kukoamine A prevents radiation-induced neuroinflammation and preserves hippocampal neurogenesis in rats by inhibiting activation of NF-κB and AP-1. It attenuates insulin resistance and fatty liver through downregulation of Srebp-1c. |
| CFN93283 | Notoginsenoside Fc Notoginsenoside Fc has perfect anti-platelet aggregatory effect. |
| CFN93123 | Aloe-emodin-8-O-beta-D-glucopyranoside Aloe-emodin-8-O-beta-D-glucopyranoside shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro. |
| CFN93651 | 7-O-Methyl morroniside 7-O-Methyl morroniside is a natural product from Lonicera morrowii. |
| CFN93652 | 7-O-ethyl-morroniside 7-O-ethyl-morroniside is a natural product from Lonicera morrowii. |
| CFN93933 | Medicagenic acid Medicagenic acid, the factor responsible for hemolytic activity of lucerne saponins.Medicagenic acid derivatives exhibit potent fungistatic effects against several plant pathogens and human dermatophytes. |
| CFN90800 | Isoliquiritin apioside Isoliquiritin apioside with marked potential to combat oxidative stress-induced genotoxicity. |
| CFN93230 | Magnocurarine Magnocurarine is a natural product from Magnolia officinalis. |
| CFN93144 | Gardenin B Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species. Gardenin B can strongly inhibit biochemical production of nitric oxide (IC50=10.59±0.4 ug/mL). |
| CFN93257 | Sotetsuflavone Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 uM, is the most active compound of this series. |
| CFN93850 | 20(S),24(R)-Ocotillol Reference standards. |
| CFN93633 | Jujuboside B1 Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides may be good source of lead compounds for novel hypnotics. |
| CFN93571 | 25S-Inokosterone 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics. |
| CFN93572 | 25R-Inokosterone 25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics. |
| CFN93373 | 20(R)-Notoginsenoside R2 Reference standards. |
| CFN93212 | Panaxynol Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. Panaxynol has neuroprotective, and anti-proliferative effects, it induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms, and protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade. Panaxynol has inhibitory effects on the proliferation of human pancreatic cancer cell PANC-1through inhibiting cell division and down-regulating Ki67 expression. |
| CFN93560 | Camelliaside B Camelliaside B is a natural product from Camellia oleifera Abel. |
| CFN93779 | Gitogenin Gitogenin is a novel selective inhibitor of UGT1A4, it is also an inhibitor of enzyme α-glucosidase with IC50 values of 37.2±0.18 uM.Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells. |
| CFN00451 | Veraguensin Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity. Veraguensin and galgravin can inhibit bone resorption and may offer novel compounds for the development of drugs to treat bone-destructive diseases such as osteoporosis. |
| CFN90801 | Ganoderic acid G Ganoderic acid G is a highly oxidized lanostane-type triterpenoid from the fungus ganoderma lucidum. |
| CFN93911 | Cowaxanthone B Cowaxanthone B shows weak antibacterial activity. |
| CFN93993 | Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin targets nuclear NOTCH2 in human solid tumor derived cell lines in vitro and inhibits melanoma growth in xenograft mouse model. Gliotoxin exhibits very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the the prominent MIC50 value of <0.03 uM. Gliotoxin also suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis. |
| CFN90906 | Handelin Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions. |
| CFN90932 | Isoescin IA Escin Ia and Isoescin IA have been traditionally used clinically as the chief active ingredients of escin, a major triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds for the treatment of chronic venous insufficiency, hemorrhoids, inflammation and edema. |
| CFN90933 | Isoescin IB Isoescin IB is a natural product from Aesculus hippocastanum L. |
| CFN90934 | Escin IB Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs. |
| CFN93351 | Polygalacin D Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2). |
| CFN90935 | Taccalonolide AJ Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo. |
| CFN90936 | Mogrol Mogrol has exhibited anti-cancer activities, it suppressed leukemia cell growth via inhibition of the ERK1/2 and STAT3 pathways, in particular, through the suppression of p-ERK1/2 and p-STAT3. Mogrol significantly improved LPS-induced memory impairment in mice. It also suppressed adipogenesis by reducing CREB activation in the initial stage of cell differentiation and by activating AMPK signaling in both the early and late stages of this process. |
| CFN90937 | 1,5-Dicaffeoylquinic acid 1,5-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.It can significantly inhibit hOAT3 transport under similar conditions. |
| CFN90938 | 1-Octacosanol 1-Octacosanol is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties, it is used as a nutritional supplement. |
| CFN92451 | Gentisic acid Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as antibiotic, anti-inflammatory, antirheumatic and antioxidant properties; it also has antimutagenic/protective effects that may contribute to human health. Gentisic acid has protective effect against cyclophosphamide induced genotoxicity and hepatotoxicity in Swiss albino mice. |
| CFN92452 | 2'-Acetylacteoside 2'-Acetylacteoside has antioxidative, hepatoprotective, and neuroprotective activities. 2'-Acetylacteoside (0.071 uM) demonstrates potent rat lens aldose reductase inhibitory activity; it can significantly suppress NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. |
| CFN93255 | 6-Demethoxytangeretin 6-Demethoxytangeretin has anti-inflammatory activity, it also can suppress production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. 6-Demethoxytangeretin can suppress the interleukin 1 (IL-1) induced production of proMMP-9/progelatinase B in rabbit synovial cells in a dose dependent manner (<64 microM). |
| CFN93256 | Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-D-glucoside shows anti-osteoarthritic effects, it reduced the expression of all OA-related molecules. |
| CFN90939 | 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone is a natural product from Artemisia argyi. |
| CFN92488 | 7-beta-Hydroxylathyrol Reference standards. |
| CFN92491 | Styraxlignolide F Styraxlignolide F is a natural product from Styrax japonica. |
| CFN90990 | Tsugaric acid A Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates that tsugaric acid A can protect keratinocytes from photodamage. |
